SPEG

Description		striated muscle enriched protein kinase
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GO Annotations	Cellular Component	Nucleus
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Muscle Organ Development Negative Regulation Of Cell Population Proliferation Cell Differentiation Muscle Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Resting heart rate ( 27798624 29769521)
Novel Interacting Genes		1 novel interacting genes: PNKD
Interacting Genes		5 interacting genes: APP HSF2BP MEOX2 PICK1 PRMT1
Entrez ID		10290
HPRD ID		10653
Ensembl ID		ENSG00000072195
Uniprot IDs		B9ZVR7 Q15772
PDB IDs		1U2H
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Neuron Projection Organization Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of JNK Cascade Modulation Of Chemical Synaptic Transmission Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Trans-Golgi Network Membrane Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Positive Regulation Of Endocytosis Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus G Protein-coupled Receptor Binding Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Receptor-mediated Endocytosis Lipoprotein Particle Growth Factor Receptor Binding Main Axon Regulation Of Receptor Internalization Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Receptor Internalization Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Glial Cell Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Protein-arginine Omega-N Monomethyltransferase Activity Striated Muscle Tissue Development Cellular Response To Starvation N-methyltransferase Activity Histone H4R3 Methyltransferase Activity GATOR1 Complex Binding Muscle Tissue Development Positive Regulation Of Hemoglobin Biosynthetic Process Peptidyl-arginine Methylation Somite Specification Membrane Curvature Sensor Activity Hydroxyacylglutathione Hydrolase Activity
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