ZMPSTE24

Description		zinc metallopeptidase STE24
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Inner Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Early Endosome Membrane Late Endosome Membrane Protein-containing Complex Extracellular Exosome
	Molecular Function	Double-stranded DNA Binding Endopeptidase Activity Metalloendopeptidase Activity Protein Binding Peptidase Activity Metalloexopeptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Liver Development Hair Follicle Development Heart Morphogenesis Ventricular Cardiac Muscle Tissue Development Cardiac Ventricle Development Growth Plate Cartilage Development DNA Repair Chromatin Organization Regulation Of DNA-templated Transcription Proteolysis Lipid Metabolic Process Inflammatory Cell Apoptotic Process DNA Damage Response Nucleus Organization Nuclear Envelope Organization Regulation Of Mitotic Cell Cycle Adult Walking Behavior Regulation Of Heart Contraction Determination Of Adult Lifespan Regulation Of Cell Shape Epidermis Development Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Glucose Metabolic Process Protein Processing Regulation Of Lipid Metabolic Process Bone Mineralization Prenylated Protein Catabolic Process Regulation Of Bone Mineralization Regulation Of TOR Signaling Regulation Of Hormone Metabolic Process Multicellular Organism Growth Regulation Of Multicellular Organism Growth Epigenetic Regulation Of Gene Expression Maintenance Of RDNA Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Gene Expression Via Chromosomal CpG Island Demethylation Regulation Of Fibroblast Proliferation Thymus Development Regulation Of Defense Response To Virus Neuromuscular Process Chromosome Organization Protein Maturation Cardiac Muscle Cell Development Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Kidney Morphogenesis Cardiac Conduction CAMKK-AMPK Signaling Cascade Regulation Of Stress-activated Protein Kinase Signaling Cascade Cellular Response To Gamma Radiation CAAX-box Protein Processing Response To DNA Damage Checkpoint Signaling Regulation Of Mitotic Cell Cycle DNA Replication Regulation Of Blood Circulation Negative Regulation Of MiRNA Processing Calcium Ion Import Into Sarcoplasmic Reticulum Regulation Of Termination Of RNA Polymerase I Transcription Regulation Of Cellular Senescence
Pathways
Drugs
Diseases		Restrictive dermopathy Mandibuloacral dysplasia
GWAS
Novel Interacting Genes		1 novel interacting genes: PTPRF
Interacting Genes
Entrez ID		10269
HPRD ID		07349
Ensembl ID		ENSG00000084073
Uniprot IDs		A0A6Q8PHG9 O75844
PDB IDs		2YPT 4AW6 5SYT 6BH8
Enriched GO Terms of Interacting Partners?		Chondroitin Sulfate Proteoglycan Binding Negative Regulation Of Receptor Binding Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Negative Regulation Of Protein Binding Regulation Of Neuron Projection Regeneration Neuron Projection Regeneration Regulation Of Axon Regeneration Transmembrane Receptor Protein Tyrosine Phosphatase Activity Peptidyl-tyrosine Dephosphorylation Synaptic Membrane Adhesion Regulation Of Protein Binding Cell Adhesion Molecule Binding Protein Dephosphorylation Protein Tyrosine Phosphatase Activity Regeneration Phosphoprotein Phosphatase Activity Dephosphorylation Heparin Binding Regulation Of Response To Wounding Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules
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