KCNMB2

Description		potassium calcium-activated channel subfamily M regulatory beta subunit 2
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GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane
	Molecular Function	Potassium Channel Activity Protein Binding Ion Channel Inhibitor Activity Calcium-activated Potassium Channel Activity Potassium Channel Regulator Activity
	Biological Process	Action Potential Detection Of Calcium Ion Monoatomic Ion Transport Potassium Ion Transport Neuronal Action Potential Regulation Of Vasoconstriction Monoatomic Ion Transmembrane Transport Potassium Ion Transmembrane Transport
Pathways		Ca2+ activated K+ channels cGMP effects
Drugs		Procaine Ritodrine Nitrendipine Miconazole Colforsin (2R,3R,4S,5R)-2-acetamido-3,4-dihydroxy-5-hydroxymethyl-piperidine Trimebutine
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 19684603) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Bipolar disorder and schizophrenia ( 22688191) Chin dimples ( 27182965) Corneal structure ( 23291589) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) Hippocampal sclerosis ( 25188341) Left ventricular obstructive tract defect (inherited effect) ( 28468790) Response to lamotrigine in genetic generalized epilepsy ( 32308125) Suicide attempts ( 30145303)
Interacting Genes		1 interacting genes: APP
Entrez ID		10242
HPRD ID		05557
Ensembl ID		ENSG00000197584
Uniprot IDs		B5BNW5 B7Z513 Q9Y691
PDB IDs		1JO6
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding Apolipoprotein Binding Response To Lead Ion Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel High-density Lipoprotein Particle Very-low-density Lipoprotein Particle Neuron Projection Maintenance RAGE Receptor Binding
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