GPC6

Description		glypican 6
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Golgi Lumen Plasma Membrane Cell Surface Membrane Lysosomal Lumen Synapse Side Of Membrane
	Molecular Function	Protein Binding Coreceptor Activity
	Biological Process	Regulation Of Signal Transduction Cell Migration Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Pathways		Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Attachment and Entry Attachment and Entry Retinoid metabolism and transport Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions
Drugs
Diseases		Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker type; Schwartz-Jampel syndrome; Simpson-Golabi-Behmel syndrome, type 1; Omodysplasia 1; Multiple exostoses
GWAS		Age at first birth ( 34211149) Alzheimer's disease ( 33074286) Alzheimer's disease (cognitive decline) ( 23535033) Arterial stiffness index ( 31235810) Attention deficit hyperactivity disorder ( 18839057) Bitter alcoholic beverage consumption ( 31046077) Blood pressure (smoking interaction) ( 25189868) Breast size ( 22747683) Chronotype ( 30696823) Disc degeneration (lumbar) ( 22993228) Heel bone mineral density ( 30598549 28869591) Interleukin-6 levels ( 33517400) Mitochondrial DNA copy number (white blood cells) ( 30704525) Morning person ( 30696823) Neuroticism (age interaction) ( 20634892) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Pelvic organ prolapse ( 26545240) Refractive error ( 32231278) Renal sinus fat ( 22044751) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) ( 24554482) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Tonometry ( 17903302) Visceral fat ( 22589738) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for body mass index ( 25673412)
Novel Interacting Genes		1 novel interacting genes: DRD2
Interacting Genes		1 interacting genes: PTPRS
Entrez ID		10082
HPRD ID		05099
Ensembl ID		ENSG00000183098
Uniprot IDs		Q9Y625
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Synaptic Transmission, Glutamatergic Cell-cell Signaling Axon Negative Regulation Of Immune System Process Regulation Of Growth Response To Histamine Regulation Of Synapse Structural Plasticity Presynaptic Membrane Dopamine Binding Regulation Of Renal Sodium Excretion Dopamine Neurotransmitter Receptor Activity Trans-synaptic Signaling Regulation Of Synapse Organization Cerebral Cortex GABAergic Interneuron Migration Modulation Of Chemical Synaptic Transmission Regulation Of Developmental Growth Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Dopamine Receptor Signaling Pathway Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway G Protein-coupled Receptor Complex Catecholamine Uptake Dopamine Uptake Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Adenohypophysis Development Negative Regulation Of Dephosphorylation Response To Inactivity Positive Regulation Of Renal Sodium Excretion Synaptic Vesicle Membrane Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Negative Regulation Of Neuron Migration Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Hyaloid Vascular Plexus Regression Regulation Of Innate Immune Response Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Neuron-neuron Synaptic Transmission Interneuron Migration From The Subpallium To The Cortex Branching Morphogenesis Of A Nerve Negative Regulation Of Dopamine Secretion Peristalsis Positive Regulation Of Growth Hormone Secretion Cell Junction Organization Positive Regulation Of Neurotransmitter Uptake Synaptic Signaling Regulation Of Dopamine Uptake Involved In Synaptic Transmission Perikaryon Regulation Of Cellular Response To Stress Heterotrimeric G-protein Binding Regulation Of Locomotion Involved In Locomotory Behavior
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