MAPK6 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
DYNC2I2	dynein 2 intermediate chain 2	Intraflagellar transport
EDF1	endothelial differentiation related factor 1
EEF1A2	eukaryotic translation elongation factor 1 alpha 2	Eukaryotic Translation Elongation
EIF1	eukaryotic translation initiation factor 1
EIF3C	eukaryotic translation initiation factor 3 subunit C	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
EIF4A1	eukaryotic translation initiation factor 4A1	ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	Copper
ELOF1	elongation factor 1 homolog
EMD	emerin	Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation Depolymerisation of the Nuclear Lamina Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane		Emery-Dreifuss muscular dystrophy
FBXL16	F-box and leucine rich repeat protein 16	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
FOXO3	forkhead box O3	Signaling by NODAL AKT phosphorylates targets in the nucleus Constitutive Signaling by AKT1 E17K in Cancer MAPK6/MAPK4 signaling Interleukin-4 and Interleukin-13 signaling Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models RUNX3 regulates BCL2L11 (BIM) transcription FLT3 Signaling Regulation of localization of FOXO transcription factors FOXO-mediated transcription of cell death genes FOXO-mediated transcription of cell death genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Regulation of FOXO transcriptional activity by acetylation FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes Estrogen-dependent nuclear events downstream of ESR-membrane signaling
FXYD3	FXYD domain containing ion transport regulator 3	Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
GALNT7	polypeptide N-acetylgalactosaminyltransferase 7	O-linked glycosylation of mucins
GATA1	GATA binding protein 1	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production		Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM) Congenital dyserythropoietic anemias (CDAs)
GLRX3	glutaredoxin 3	Iron uptake and transport
GORASP1	golgi reassembly stacking protein 1	Golgi Cisternae Pericentriolar Stack Reorganization Golgi Cisternae Pericentriolar Stack Reorganization COPII-mediated vesicle transport COPI-mediated anterograde transport
GPX1	glutathione peroxidase 1	Synthesis of 5-eicosatetraenoic acids Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives Detoxification of Reactive Oxygen Species Purine catabolism	Glutathione Glutathione Glutathione disulfide Cannabidiol Medical Cannabis Nabiximols	Anemia due to disorders of glutathione metabolism, including: Glucose-6-phosphate dehydrogenase (G6PD) deficiency; Glutathione peroxidase (GPX) deficiency; Gamma-glutamylcysteine synthetase (GCLC) deficiency; Glutathione synthetase (GSS) deficiency
HACL1	2-hydroxyacyl-CoA lyase 1	Alpha-oxidation of phytanate Peroxisomal protein import Peroxisomal protein import
HAUS2	HAUS augmin like complex subunit 2	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
HDAC11	histone deacetylase 11	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway	Belinostat Panobinostat
HIP1	huntingtin interacting protein 1	Clathrin-mediated endocytosis

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