ARNT2 and PDE4DIP

Number of citations of the paper that reports this interaction (PubMedID 24722188)
69

Data Source:
BioGRID (two hybrid)

		ARNT2	PDE4DIP
Description		aryl hydrocarbon receptor nuclear translocator 2	phosphodiesterase 4D interacting protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Aryl Hydrocarbon Receptor Complex	Nucleus Cytoplasm Golgi Apparatus Centrosome Microtubule Organizing Center Cytoskeleton Myofibril Cortical Microtubule Plus-end
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Aryl Hydrocarbon Receptor Binding Protein-containing Complex Binding Protein Heterodimerization Activity Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding	Protein Binding Enzyme Binding Molecular Adaptor Activity
	Biological Process	Response To Hypoxia In Utero Embryonic Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Brain Development Positive Regulation Of Cell Population Proliferation Response To Estradiol Negative Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Centrosome Cycle Astral Microtubule Organization Protein-containing Complex Assembly Positive Regulation Of Microtubule Nucleation Regulation Of Golgi Organization
Pathways		PPARA activates gene expression Phase I - Functionalization of compounds Endogenous sterols Xenobiotics Aryl hydrocarbon receptor signalling NPAS4 regulates expression of target genes NPAS4 regulates expression of target genes
Drugs
Diseases
GWAS		Atrial fibrillation ( 29892015 30061737) Attention deficit hyperactivity disorder ( 29325848) Bipolar disorder ( 20351715) Body mass index ( 26426971) Gut microbiota relative abundance (unclassified genus belonging to family Erysipelotrichaceae) ( 33208821) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245)	Capecitabine sensitivity ( 22864933) Cutaneous mastocytosis ( 32752121) Macrovascular complications in type 2 diabetes ( 33430853) Mastocytosis ( 32752121)
Interacting Genes		69 interacting genes: ADAMTSL4 AHR AP1M1 AP3M1 APP ARNT CALCOCO2 CAPN7 CCDC33 CDR2 CEP57L1 CEP63 CTBP1 DGCR6 DTX2 DYDC1 EPAS1 FAAP20 GOLGA2 HIF1A IKZF3 KIFC3 LMO2 LMO4 LZTS2 MAGEA4 MAGED1 MEIS2 MEOX2 MIPOL1 MTDH MTUS2 NCOA3 NDE1 NPAS2 NPAS4 OSGIN1 PDE4DIP PLSCR1 PSMB1 RBCK1 REL RFX6 RIMBP3 RINT1 SH3GL2 SIM1 SORBS3 SPAG5 SSBP3 SSX2IP STK16 SYCE1 TACC3 TADA2A TAX1BP3 TFIP11 TRAF1 TRAF2 TRIM23 TRIM27 TRIM37 TRIM42 TRIP6 TSPOAP1 USHBP1 USP7 VPS52 ZNF341	98 interacting genes: ADH1B AEN AIRIM AKTIP ANKRD11 ARNT2 BYSL CCDC146 CCDC198 CDC5L CDKN1A CHCHD3 CHD1L CLIP4 CWF19L2 DSCAM DSCR9 EGR2 EIF4E2 FAM161A FAM50B FAM74A4 FCHSD2 FES FHL1 GADD45G GBE1 GFI1B GNRHR2 GOLGA5 GOLGA8EP GOLGA8F HAUS1 HOXB5 HOXC8 ITSN2 KDM1A KLC3 KLC4 KRAS KRT1 KRT18 KRT31 LAMTOR3 LENG1 LIN37 LMO4 MAPRE3 MIF4GD MTUS2 MYBPC2 MYOM1 NAA10 NEFL NEK2 OSGEP PDE4D PEA15 PFDN1 PIAS4 PPP1R18 PRNP PRPF31 PYGM RBM8A RSPH1 RTP5 SCNM1 SDCBP SH2D4A SHFL SMN1 SNCA TEAD4 TFIP11 THRB TK1 TMOD4 TNIK TRAF4 TULP3 UTP14C VAC14 ZBTB24 ZBTB38 ZBTB4 ZDHHC17 ZFYVE21 ZKSCAN3 ZNF124 ZNF408 ZNF410 ZNF414 ZNF512B ZNF581 ZNF587 ZNF696 ZSCAN26
Entrez ID		9915	9659
HPRD ID		06915	10482
Ensembl ID		ENSG00000172379	ENSG00000178104
Uniprot IDs		Q86TN1 Q9HBZ2 X5DQN9	A0A075B749 A0A8Q3SI21 A0A8Q3SI83 A0A8Q3WM32 A0A994J5E0 E9PQG4 Q5VU43
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Protein Binding Positive Regulation Of Macromolecule Biosynthetic Process Transcription Coactivator Activity Positive Regulation Of Biosynthetic Process Transcription Regulator Complex Protein Dimerization Activity Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Cytoplasm Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Macromolecule Metabolic Process Nuclear Aryl Hydrocarbon Receptor Complex Nucleus Microtubule Organizing Center Organization DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Centrosome Protein Heterodimerization Activity DNA-binding Transcription Factor Activity Chromatin Microtubule-based Process Positive Regulation Of Autophagy Regulation Of Primary Metabolic Process Establishment Of Localization In Cell Benzodiazepine Receptor Binding Positive Regulation Of Glycolytic Process Embryonic Placenta Development Regulation Of Macromolecule Biosynthetic Process Cytoskeleton Intracellular Transport Regulation Of Gene Expression Tumor Necrosis Factor Receptor Binding Positive Regulation Of NF-kappaB Transcription Factor Activity Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process Aryl Hydrocarbon Receptor Complex Regulation Of Metabolic Process Intestinal Epithelial Structure Maintenance Positive Regulation Of ATP Metabolic Process Microtubule RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Identical Protein Binding	Nucleoplasm Zinc Ion Binding Nucleus Cytoskeleton Organization Cytoskeleton Protein Binding DNA-binding Transcription Factor Activity
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