KIAA0319 and FEM1B

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
HPRD (two hybrid)

		KIAA0319	FEM1B
Description		KIAA0319	fem-1 homolog B
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GO Annotations	Cellular Component	Endosome Early Endosome Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Cul2-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding	Death Receptor Binding Protein Binding Metal Ion Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Neuron Migration Nervous System Development Sensory Perception Of Sound Response To Auditory Stimulus Thalamus Development Central Nervous System Neuron Development Negative Regulation Of Axon Extension Multicellular Organismal Response To Stress Vocal Learning Negative Regulation Of Axon Extension Involved In Regeneration Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Dendrite Development	Epithelial Cell Maturation Apoptotic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Branching Involved In Prostate Gland Morphogenesis Epithelial Cell Maturation Involved In Prostate Gland Development Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of DNA Damage Checkpoint
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Neddylation
Drugs
Diseases
GWAS		Radiation response ( 20923822) Serum uric acid levels ( 30993211) Waist-to-hip ratio adjusted for BMI ( 28552196)	Hematocrit ( 32888494) Hemoglobin ( 32888494) Major depressive disorder ( 23377640) Systolic blood pressure ( 26969751)
Interacting Genes		3 interacting genes: APP FEM1B SH2B1	10 interacting genes: APAF1 CDK5R1 FAS GLI1 KIAA0319 NKX3-1 PPM1F RAD9A SMCR8 TLE3
Entrez ID		9856	10116
HPRD ID		18713	16889
Ensembl ID		ENSG00000137261	ENSG00000169018
Uniprot IDs		A0A087X0U9 Q5VV43	Q9UK73
PDB IDs		2E7M	6LBF 7CNG 7EL6 8IJ1 8JE1 8JE2 8WQA 8WQB 8WQC 8WQD 8WQE 8WQF 8WQG 8WQH 8WQI
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Developmental Maturation Amylin Binding Endosome To Plasma Membrane Transport Vesicle Cell Maturation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Cell Cycle Epithelial Cell Maturation Involved In Prostate Gland Development Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Positive Regulation Of Cell Cycle Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Regulation Of Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle	Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Prostate Gland Development Regulation Of Apoptotic Signaling Pathway Signal Transduction Response To G1 DNA Damage Checkpoint Signaling Notochord Regression Positive Regulation Of Androgen Secretion MADS Box Domain Binding Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Response To Xenobiotic Stimulus Regulation Of Apoptotic Process Apoptotic Signaling Pathway Regulation Of Programmed Cell Death Response To Oxygen Levels Apoptotic Process Dorsal Aorta Development Superior Olivary Nucleus Maturation Negative Regulation Of Axon Extension Involved In Regeneration Cell Death Programmed Cell Death Apoptosome Neuron Apoptotic Process Fas Signaling Pathway Ventral Midline Development Protein Kinase 5 Complex Protein Kinase Binding GLI-SUFU Complex Salivary Gland Development Cellular Response To Hyperoxia Negative Regulation Of Canonical Wnt Signaling Pathway Cerebellar Cortex Morphogenesis Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Positive Regulation Of Intracellular Signal Transduction Histone Deacetylase Binding Checkpoint Clamp Complex Positive Regulation Of Organelle Organization G1 To G0 Transition Involved In Cell Differentiation Calmodulin-dependent Protein Phosphatase Activity Regulation Of Cellular Response To Stress Neuron Migration Regulation Of Intracellular Signal Transduction
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