RUSC2 and SIGMAR1

		RUSC2	SIGMAR1
Description		RUN and SH3 domain containing 2	sigma non-opioid intracellular receptor 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Cytoplasmic Vesicle Extracellular Exosome	Nucleus Nuclear Envelope Nuclear Inner Membrane Nuclear Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Plasma Membrane Postsynaptic Density Membrane Growth Cone Cytoplasmic Vesicle Cell Projection Synapse Postsynaptic Membrane Anchoring Junction Postsynapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding Small GTPase Binding	G Protein-coupled Opioid Receptor Activity Protein Binding Signaling Receptor Activity Identical Protein Binding
	Biological Process		Lipid Transport Nervous System Development G Protein-coupled Opioid Receptor Signaling Pathway Regulation Of Neuron Apoptotic Process Protein Homotrimerization Regulation Of Postsynapse Assembly
Pathways			Potential therapeutics for SARS
Drugs			Amitriptyline Remoxipride Haloperidol Dextromethorphan Nortriptyline Fenfluramine Pentazocine Naltrexone Cocaine Hydrocodone Sertraline Dimethyltryptamine Prasterone Phencyclidine Pimavanserin Noscapine Captodiame Pentoxyverine
Diseases
GWAS		Psoriasis ( 25903422)
Interacting Genes		12 interacting genes: DLST EGFR FXR1 GIT2 GOLGA2 KHDRBS1 KLC2 MAGEC1 RAB1A RAB1B SIGMAR1 SRPRA	15 interacting genes: ANK2 DCAF12 DNAJB5 GHSR GNE ITPR3 NFX1 PDZD11 PHF24 RECK RUSC2 SPAG8 SPINK4 SRI VCP
Entrez ID		9853	10280
HPRD ID		18009	03580
Ensembl ID		ENSG00000198853	ENSG00000147955
Uniprot IDs		Q8N2Y8	A0A7P0T9D5 A0A7P0Z4C2 B4DR71 Q99720
PDB IDs		6IF2	5HK1 5HK2 6DJZ 6DK0 6DK1
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Glycoprotein Metabolic Process Positive Regulation Of Protein Metabolic Process Virion Assembly Cadherin Binding Establishment Of Endothelial Intestinal Barrier Golgi Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cellular Localization Regulation Of Protein Metabolic Process Establishment Of Endothelial Barrier Endothelial Cell Development Dihydrolipoyllysine-residue Succinyltransferase Activity Multivesicular Body, Internal Vesicle Lumen Grb2-Sos Complex Kinesin I Complex Golgi Membrane Golgi Vesicle Transport Establishment Of Protein Localization Organelle Assembly G Protein Activity GTPase Activity Shc-EGFR Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine Oxoadipate Dehydrogenase Complex Positive Regulation Of Protein Kinase C Signaling Negative Regulation Of Catabolic Process Epidermal Growth Factor Receptor Activity Autophagosome Assembly GTP Binding Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Autophagosome Organization L-lysine Catabolic Process Membrane Epidermal Growth Factor Binding Positive Regulation Of Protein Glycosylation Establishment Of Localization In Cell Signal Recognition Particle Receptor Complex
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