ARHGEF11 and PLXNB2

Number of citations of the paper that reports this interaction (PubMedID 12123608)
0

Data Source:
BioGRID (two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology)
HPRD (two hybrid)

		ARHGEF11	PLXNB2
Description		Rho guanine nucleotide exchange factor 11	plexin B2
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane	Semaphorin Receptor Complex Plasma Membrane Cell Surface Membrane Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Binding Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding	Transmembrane Signaling Receptor Activity Protein Binding Semaphorin Receptor Activity Signaling Receptor Activity
	Biological Process	Regulation Of Cell Growth Striated Muscle Contraction G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Establishment Of Cell Polarity Actin Cytoskeleton Organization Positive Regulation Of DNA-templated Transcription Regulation Of Small GTPase Mediated Signal Transduction	Neural Tube Closure Regulation Of Protein Phosphorylation Cytoplasmic Translation Receptor-mediated Endocytosis Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Cell Adhesion Neuroblast Proliferation Synapse Assembly Brain Development Regulation Of Cell Shape Regulation Of Neuron Projection Development Positive Regulation Of Neuron Projection Development Regulation Of Cell Migration Positive Regulation Of Cell Projection Organization Negative Regulation Of Translation In Response To Stress Cellular Response To Stress TRNA Stabilization Regulation Of GTPase Activity Positive Regulation Of Translation Positive Regulation Of Axonogenesis Regulation Of Protein Metabolic Process Semaphorin-plexin Signaling Pathway Excitatory Synapse Assembly Regulation Of Neuron Migration
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chin dimples ( 27182965) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Heel bone mineral density ( 30598549) Height ( 31562340) Lymphocyte count ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Acne (severe) ( 24927181) Blond vs. brown/black hair color ( 30531825) Blood protein levels ( 30072576) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lymphocyte count ( 32888494) Nevus count or cutaneous melanoma ( 32341527) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Sensorimotor dexterity ( 31596458) Systolic blood pressure ( 30224653)
Interacting Genes		17 interacting genes: ABCA1 CDC42 GNA12 GNA13 KLHL20 LPAR1 LPAR2 MAP1A MAP1B NEK2 PLXNB1 PLXNB2 PLXNB3 PTPRF RHOA RPS6KA1 SLC1A6	9 interacting genes: AIFM2 ARHGEF11 ARHGEF12 CENPU HDLBP HMOX2 PFDN1 PTN RND1
Entrez ID		9826	23654
HPRD ID		09302	05050
Ensembl ID		ENSG00000132694	ENSG00000196576
Uniprot IDs		A0AAQ5BIK5 O15085	O15031
PDB IDs		1HTJ 1XCG 2DLS 3KZ1 3T06 5E6P 5JHG 5JHH 5TYT	4E71
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Shape Regulation Of Cellular Component Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Semaphorin-plexin Signaling Pathway Regulation Of Neuron Projection Development Regulation Of Cell Morphogenesis Cell Junction Assembly Semaphorin Receptor Activity Semaphorin Receptor Complex Positive Regulation Of Cellular Component Organization Regulation Of Biological Quality G Protein Activity Glutamatergic Synapse Neuronal Cell Body Positive Regulation Of Cell Projection Organization D5 Dopamine Receptor Binding Positive Regulation Of Axonogenesis Regulation Of Rho Protein Signal Transduction Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of Cell Migration Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Plasma Membrane Regulation Of Developmental Process Regulation Of Cell Motility Positive Regulation Of Rho Protein Signal Transduction Synapse Assembly Regulation Of Locomotion Cell Junction Organization Lysophosphatidic Acid Receptor Activity Regulation Of Cytoskeleton Organization Apolipoprotein A-I-mediated Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Anatomical Structure Morphogenesis Regulation Of Axonogenesis Membrane Invagination Cell Migration Rho-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Supramolecular Fiber Organization Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Actin Filament Bundle Assembly Ossification Involved In Bone Maturation Rho Protein Signal Transduction Cell Motility Regulation Of Intracellular Signal Transduction Endocytic Vesicle
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