SPATA2 and ATP6V1H

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SPATA2	ATP6V1H
Description		spermatogenesis associated 2	ATPase H+ transporting V1 subunit H
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol	Golgi Membrane Vacuolar Proton-transporting V-type ATPase, V1 Domain Lysosomal Membrane Cytosol Plasma Membrane Endosome Membrane Membrane Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Proton-transporting V-type ATPase Complex Extracellular Exosome Extrinsic Component Of Synaptic Vesicle Membrane
	Molecular Function	Protein Binding Signaling Receptor Complex Adaptor Activity Protein-containing Complex Binding Ubiquitin-specific Protease Binding	Protein Binding ATP Hydrolysis Activity Enzyme Regulator Activity Proton-transporting ATPase Activity, Rotational Mechanism
	Biological Process	Spermatogenesis Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Programmed Cell Death Regulation Of Inflammatory Response Regulation Of Necroptotic Process Necroptotic Process Protein K63-linked Deubiquitination Seminiferous Tubule Development Protein Linear Deubiquitination	Monoatomic Ion Transport Endocytosis Vacuolar Acidification Lysosomal Lumen Acidification Regulation Of Macroautophagy Endosomal Lumen Acidification Intracellular PH Reduction Golgi Lumen Acidification Proton Transmembrane Transport
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway	ROS and RNS production in phagocytes Nef Mediated CD4 Down-regulation Nef Mediated CD8 Down-regulation Insulin receptor recycling Transferrin endocytosis and recycling Blockage of phagosome acidification Amino acids regulate mTORC1 Ion channel transport Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy
Drugs			Tiludronic acid
Diseases
GWAS		Coronary artery disease ( 29212778) Gut microbiota (beta diversity) ( 27723756) Psoriasis ( 18364390 20953189 25574825)	Bipolar disorder with mood-incongruent psychosis ( 23092984) Cerebrospinal fluid beta-site APP cleaving enzyme levels ( 29751835) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)
Interacting Genes		22 interacting genes: ANKRD11 APP ATP6V1H CATSPERT CCDC102B CEP72 DUT EFHC1 GOLGA2 GPANK1 KAT5 KIFC3 LENG1 MAD1L1 OTULIN PTPN6 TBC1D22B TNIP1 TRAF2 TRIM27 UBC ZNF835	10 interacting genes: ATP6V1E1 CDKN2B ETHE1 FLACC1 PPP1R12C SNPH SOX9 SPATA2 TANK TRIM14
Entrez ID		9825	51606
HPRD ID		09636	10591
Ensembl ID		ENSG00000158480	ENSG00000047249
Uniprot IDs		A8K0S9 B4DID4 Q9UM82	B3KUZ7 Q9UI12
PDB IDs		5LJM 5LJN	6WM2 6WM3 6WM4 7FDA 7FDB 7FDC 7U4T 7UNF
Enriched GO Terms of Interacting Partners?		Microtubule-based Process Spindle Pole Pattern Recognition Receptor Signaling Pathway CD27 Signaling Pathway Positive Regulation Of Mitotic Sister Chromatid Segregation Innate Immune Response-activating Signaling Pathway Innate Immune Response Activation Of Innate Immune Response Regulation Of Metaphase Plate Congression Identical Protein Binding Regulation Of Innate Immune Response Defense Response To Symbiont Defense Response To Other Organism Positive Regulation Of Defense Response Cytoplasmic Pattern Recognition Receptor Signaling Pathway Attachment Of Mitotic Spindle Microtubules To Kinetochore Protein Serine/threonine Kinase Binding Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Immune Response Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Defense Response Response To External Biotic Stimulus DUTP Catabolic Process DUTP Diphosphatase Activity Spindle Organization Positive Regulation Of Protein Modification Process Mitotic Spindle Regulation Of Autophagy Microtubule Cytoskeleton Organization Involved In Mitosis Positive Regulation Of Innate Immune Response Epididymis Development Immune Response-activating Signaling Pathway TORC2 Complex Disassembly Mitotic Spindle Pole Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Chromosome Segregation MAD1 Complex Histone H2AK5 Acetyltransferase Activity Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Microtubule-based Movement Regulation Of Cytokine-mediated Signaling Pathway Cytoskeleton Immune Response-regulating Signaling Pathway Regulation Of Inflammatory Response Activation Of Immune Response	Proton-transporting Two-sector ATPase Complex, Catalytic Domain Response To Interleukin-1 Neural Crest Cell Fate Specification Male Germ-line Sex Determination Cellular Response To Interleukin-1 Negative Regulation Of Beta-catenin-TCF Complex Assembly Bronchus Cartilage Development Ureter Urothelium Development Epithelial Cell Proliferation Involved In Prostatic Bud Elongation Regulation Of Cell Proliferation Involved In Tissue Homeostasis Ureter Smooth Muscle Cell Differentiation Lung Smooth Muscle Development Intrahepatic Bile Duct Development Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Ubiquitin-specific Protease Activity Sulfur Dioxygenase Activity Cytoplasm Proton-transporting Two-sector ATPase Complex Negative Regulation Of Epithelial Cell Proliferation Cellular Response To Cell-matrix Adhesion Negative Regulation Of Photoreceptor Cell Differentiation Metanephric Tubule Formation Stem Cell Fate Specification Renal Vesicle Induction Metanephric Nephron Tubule Formation Positive Regulation Of Mesenchymal Stem Cell Differentiation Chondrocyte Hypertrophy Cell Proliferation Involved In Heart Morphogenesis Trachea Cartilage Development Response To Heparin Prostate Gland Morphogenesis Cellular Response To Heparin Regulation Of Branching Involved In Lung Morphogenesis Endochondral Bone Morphogenesis Anterior Head Development Primary Sex Determination Harderian Gland Development Astrocyte Fate Commitment Common Bile Duct Development Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Growth Plate Cartilage Chondrocyte Growth Lacrimal Gland Development Protein Linear Deubiquitination Protein Deubiquitination Protein Modification By Small Protein Removal Positive Regulation Of Protein Deubiquitination Hydrogen Sulfide Metabolic Process Myosin Phosphatase Regulator Activity Phosphatase Regulator Activity Ureter Development
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