DHX38 and BCO1

		DHX38	BCO1
Description		DEAH-box helicase 38	beta-carotene oxygenase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Membrane Catalytic Step 2 Spliceosome Ribonucleoprotein Complex	Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On RNA Hydrolase Activity ATP Hydrolysis Activity 3'-5' RNA Helicase Activity	Beta-carotene 15,15'-dioxygenase Activity Carotenoid Dioxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Metal Ion Binding Dioxygenase Activity
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing	Retinoid Metabolic Process Lipid Metabolic Process Carotene Catabolic Process Vitamin A Biosynthetic Process Retinol Metabolic Process Retinal Metabolic Process Beta-carotene Metabolic Process
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination	Retinoid metabolism and transport
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Blood protein levels ( 23696881) Cholesterol, total ( 20686565 25961943) Coronary artery disease ( 29212778) Depression ( 29700475) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) LDL cholesterol ( 20686565 25961943) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolite levels ( 22916037) Red blood cell count ( 32888494) Serum metabolite levels (CMS) ( 31636271) Urate levels ( 31578528)
Interacting Genes		17 interacting genes: AARS1 ACTL7B BCO1 CDC40 CMTM3 CSNK2A1 CTCF E2F4 MFAP1 NDRG4 NOL3 PPP4C RNF10 SNRNP200 TNFRSF4 U2AF1 WBP4	1 interacting genes: DHX38
Entrez ID		9785	53630
HPRD ID		05720	12042
Ensembl ID		ENSG00000140829	ENSG00000135697
Uniprot IDs		Q92620	Q9HAY6
PDB IDs		5YZG 6ZYM 7A5P 8I0W
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process MRNA Splicing, Via Spliceosome Spliceosomal Complex RNA Splicing RNA Splicing, Via Transesterification Reactions MRNA Processing RNA Processing U2-type Precatalytic Spliceosome RNA Metabolic Process Nucleic Acid Metabolic Process Catalytic Step 2 Spliceosome Nucleobase-containing Compound Metabolic Process RNA Binding Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Cytoplasmic Translational Fidelity Response To Injury Involved In Regulation Of Muscle Adaptation Negative Regulation Of Muscle Atrophy Chromatin Loop Anchoring Activity Spliceosome Conformational Change To Release U4 (or U4atac) And U1 (or U11) Vitamin A Biosynthetic Process Beta-carotene Metabolic Process Nucleus Peptide Lactyltransferase (ATP-dependent) Activity Macromolecule Metabolic Process Ser-tRNA(Ala) Deacylase Activity Cis Assembly Of Pre-catalytic Spliceosome Carotene Metabolic Process Carotenoid Dioxygenase Activity Carotene Catabolic Process Nucleic Acid Binding	3'-5' RNA Helicase Activity ATP-dependent Activity, Acting On RNA RNA Helicase Activity Catalytic Step 2 Spliceosome Helicase Activity MRNA Splicing, Via Spliceosome Spliceosomal Complex RNA Splicing, Via Transesterification Reactions
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