KMT2B and SEPTIN8

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		KMT2B	SEPTIN8
Description		lysine methyltransferase 2B	septin 8
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex MLL1/2 Complex	Cytoplasm Cytoskeleton Septin Ring Microtubule Cytoskeleton Membrane Axon Synaptic Vesicle Membrane Septin Complex Cytoplasmic Vesicle Cell Division Site Cell Projection Synapse Presynapse
	Molecular Function	DNA Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone H3K4 Methyltransferase Activity Unmethylated CpG Binding Metal Ion Binding Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Molecular Adaptor Activity
	Biological Process	Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Methylation Positive Regulation Of DNA-templated Transcription	Intracellular Protein Localization Regulation Of Protein Stability Regulation Of Intracellular Protein Transport Regulation Of SNARE Complex Assembly Cytoskeleton-dependent Cytokinesis
Pathways		PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Formation of WDR5-containing histone-modifying complexes Formation of WDR5-containing histone-modifying complexes
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Eosinophil percentage of white cells ( 32888494) Refractive error ( 32231278)
Interacting Genes		27 interacting genes: ANXA1 ANXA7 ASH2L ATP1B1 ATXN1 CDKN1A GRB7 H3C1 H3C14 MTDH NREP PIK3R3 PIN1 PRPF40A RAP1B RBBP5 RCC1 RPP14 SEPTIN8 SMAD3 SMARCB1 SMN1 TK1 TRIM55 TRIM63 TSC22D1 ZNF512B	12 interacting genes: A2M ACSL6 CDK14 ESR1 JADE1 KMT2B PPHLN1 SEPTIN4 SEPTIN5 SH3GL1 SH3GL3 SPTBN1
Entrez ID		9757	23176
HPRD ID		06017	12228
Ensembl ID		ENSG00000272333	ENSG00000164402
Uniprot IDs		A0A669KBI7 Q9UMN6	A6NFQ9 B7ZVZ1 Q92599
PDB IDs		3UVM 4ERZ 4PZI 7BRE	6UPR 6WSM
Enriched GO Terms of Interacting Partners?		Regulation Of Gene Expression Nucleus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Gene Expression, Epigenetic MLL1/2 Complex Transcription Initiation-coupled Chromatin Remodeling Regulation Of Macromolecule Biosynthetic Process MLL3/4 Complex Nucleoplasm Set1C/COMPASS Complex Intracellular Signaling Cassette Epithelial Cell Differentiation	Cytoskeleton-dependent Cytokinesis Cell Division Site Septin Ring Septin Complex Central Nervous System Development Presynapse Protein Localization To Chromatin
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