N4BP1 and MID1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		N4BP1	MID1
Description		NEDD4 binding protein 1	midline 1
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GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol PML Body	Cytoplasm Golgi Apparatus Spindle Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Cytoplasmic Microtubule Microtubule Cytoskeleton Centriolar Satellite
	Molecular Function	RNA Binding MRNA Binding Nuclease Activity RNA Nuclease Activity Protein Binding Hydrolase Activity Ubiquitin Binding	Protein Binding Microtubule Binding Zinc Ion Binding Transferase Activity Enzyme Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Phosphoprotein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Cytokine Production Immune System Process Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To UV Negative Regulation Of Viral Genome Replication Innate Immune Response Regulation Of Innate Immune Response	Microtubule Cytoskeleton Organization Negative Regulation Of Microtubule Depolymerization Pattern Specification Process Positive Regulation Of Stress-activated MAPK Cascade Protein Localization To Microtubule Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Intracellular Signal Transduction
Pathways		Regulation of NF-kappa B signaling	Interferon gamma signaling
Drugs
Diseases			Opitz-GBBB syndrome
GWAS		Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Neutrophil percentage of granulocytes ( 27863252) Serum metabolite levels ( 33031748) Social autistic-like traits ( 24133439) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		8 interacting genes: AZI2 CDK6 ITCH LITAF LSM1 MID1 NEDD8 UBC	46 interacting genes: BYSL CDC37 CRY2 DYRK4 EHHADH ELOA EPN2 FAM50B FKBP1A GMCL1 HMG20B HTT IGBP1 KIF9 MEOX1 MID1IP1 MID2 N4BP1 OTUB2 PAX6 PDE4B PKN1 PPM1A PPP2CA PPP2CB PTCD2 PTPA RIC8A SPAG5 STK36 TCEANC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2L3 UBE2L6 UBE2N UBE2V1 UBE2W UBTD1 ZNF618
Entrez ID		9683	4281
HPRD ID			02047
Ensembl ID		ENSG00000102921	ENSG00000101871
Uniprot IDs		O75113	A0A087X255 A0A8I5KPE0 A0A8I5KR14 O15344
PDB IDs		6Q3V	2DQ5 2FFW 2JUN 5IM8 7QRY
Enriched GO Terms of Interacting Partners?		Regulation Of Hematopoietic Stem Cell Differentiation Protein Tag Activity Regulation Of Hematopoietic Progenitor Cell Differentiation T Cell Activation Ubiquitin Protein Ligase Binding Endosome Membrane Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Stem Cell Differentiation Response To Virus Cytoplasm Cyclin D3-CDK6 Complex Lymphocyte Activation Cyclin D1-CDK6 Complex Cyclin D2-CDK6 Complex FBXO Family Protein Binding Macromolecule Catabolic Process Cytoplasmic Side Of Late Endosome Membrane Negative Regulation Of Canonical NF-kappaB Signal Transduction Gliogenesis Negative Regulation Of Monocyte Differentiation Leukocyte Activation Cell Dedifferentiation Cell Activation Response To External Biotic Stimulus Cellular Response To Camptothecin Protein Ubiquitination Modification-dependent Protein Catabolic Process Cytoplasmic Side Of Early Endosome Membrane Lsm1-7-Pat1 Complex Dendritic Cell Proliferation Leukocyte Proliferation Mononuclear Cell Proliferation Positive Regulation Of T Cell Anergy CXCL12-activated CXCR4 Signaling Pathway T Cell Tolerance Induction T Cell Anergy Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation C-X-C Chemokine Receptor CXCR4 Signaling Pathway Early Endosome Membrane Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway Regulation Of T Cell Anergy Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Receptor Catabolic Process CD4-positive, Alpha-beta T Cell Proliferation Arrestin Family Protein Binding Positive Regulation Of T Cell Tolerance Induction Lateral Ventricle Development Type B Pancreatic Cell Development Post-translational Protein Modification	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Modification Process Protein K48-linked Ubiquitination Protein Ubiquitination Protein K11-linked Ubiquitination Protein Monoubiquitination ISG15 Transferase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process ATP Binding ISG15-protein Conjugation Nucleus Nucleotide Binding Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Protein K63-linked Ubiquitination Macromolecule Metabolic Process Transferase Activity Protein Phosphatase Type 2A Complex Macromolecule Catabolic Process Positive Regulation Of Protein Polyubiquitination Protein Binding UBC13-MMS2 Complex Regulation Of Metabolic Process Regulation Of Gene Expression Phosphoprotein Phosphatase Activity Cytosol Ubiquitin Conjugating Enzyme Complex Regulation Of Macromolecule Biosynthetic Process Regulation Of Post-translational Protein Modification Regulation Of Macromolecule Metabolic Process Proteolysis Negative Regulation Of Signal Transduction Regulation Of Protein Polyubiquitination Regulation Of Microtubule-based Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Ubiquitin Binding Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein Ubiquitination Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Regulation Of Primary Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin Ligase Complex
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