SDC3 and TMEM218

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SDC3	TMEM218
Description		syndecan 3	transmembrane protein 218
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Lumen Plasma Membrane Cell Surface Membrane Extracellular Matrix Lysosomal Lumen Microspike	Cilium Membrane Cell Projection
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding
	Biological Process	Cell Migration
Pathways		Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Syndecan interactions Syndecan interactions Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Attachment and Entry Attachment and Entry Retinoid metabolism and transport Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions
Drugs
Diseases
GWAS		Loneliness ( 27629369) Systolic blood pressure ( 34074324)	Breast cancer (survival) ( 25890600) Familial lung adenocarcinoma ( 29924316)
Interacting Genes		32 interacting genes: AGR2 CASK CMTM7 COL5A1 CSK CTTN CUX1 EPHB4 FGF2 FYN ITGB4 KCNJ2 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP2-3 KRTAP2-4 KRTAP4-2 KRTAP5-7 KRTAP5-9 KRTAP9-2 LCE3D MDK PLN PTN SLC35A1 SMIM1 TMEM14C TMEM218 TUBA1A TUBB TUBB2A	75 interacting genes: APH1A AQP2 AQP6 ARL13B ASZ1 ATP6V0E1 BSCL2 CD300A CD53 CD79A CLDN2 CLEC10A CLEC17A CPLX4 CREB3L1 CTLA4 DAGLA EBP ELOVL2 ELOVL4 EMP1 ERGIC3 FAM209A FCER1G FFAR2 FRMD3 GDAP1 GJB1 GJB4 GJB6 GPR152 GPR61 GPX8 HSD17B13 IFNGR2 KCNJ6 KCNK5 KIR2DL3 LDLRAD1 LHFPL5 LMNA LSMEM2 MFF MS4A3 MTIF3 MUC1 NPFFR2 PCNA PDCD1LG2 PIK3IP1 PLEKHO1 PSCA RETREG3 SAR1A SDC3 SLC10A4 SLC10A6 SLC18A1 SMIM3 SSMEM1 TM4SF18 TMED8 TMEM106C TMEM182 TMEM207 TMEM234 TMEM31 TMEM45B TMEM52B TMEM88 TMPRSS2 TRHR TSPAN12 TSPAN18 VSIR
Entrez ID		9672	219854
HPRD ID		01719	19054
Ensembl ID		ENSG00000162512	ENSG00000150433
Uniprot IDs		O75056	A2RU14 E9PI23
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Response To Mechanical Stimulus Cell Motility Cell Migration Positive Regulation Of Blood Vessel Branching Regulation Of Blood Vessel Branching Regulation Of Calcium Ion Import Leukocyte Chemotaxis Involved In Inflammatory Response Integrin Binding Cell Projection Morphogenesis Positive Regulation Of Chemotaxis Learning Or Memory Chondroitin Sulfate Binding Positive Regulation Of Hepatocyte Proliferation Dendritic Spine Maintenance Estrous Cycle Heparin Binding Anatomical Structure Morphogenesis Learning Relaxation Of Cardiac Muscle Cognition Regulation Of Response To Wounding Regulation Of Hepatocyte Proliferation Basement Membrane Proline-rich Region Binding Regulation Of Chemotaxis Positive Regulation Of Cell Division Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Vascular Endothelial Cell Proliferation Response To L-glutamate Relaxation Of Muscle Positive Regulation Of Oligodendrocyte Differentiation Cerebral Cortex Development Response To Auditory Stimulus Ovulation Cycle Leukocyte Migration Involved In Inflammatory Response Neuron Projection Arborization Positive Regulation Of Neurogenesis Positive Regulation Of Stem Cell Differentiation Schaffer Collateral - CA1 Synapse Structural Constituent Of Cytoskeleton Identical Protein Binding Cell Migration Involved In Sprouting Angiogenesis Glial Cell Differentiation Calcium Ion Transport Dentate Gyrus Development Integrin Biosynthetic Process Developmental Process Protein Tyrosine Kinase Activity	Membrane Plasma Membrane Protein Binding Connexin Complex Regulation Of Myoblast Fusion Gap Junction Channel Activity Gap Junction Bile Acid:sodium Symporter Activity Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Fucose Binding Gap Junction-mediated Intercellular Transport Renal Water Transport Gap Junction Assembly Fatty Acid Elongation, Saturated Fatty Acid
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