IPO13 and EIF3I

		IPO13	EIF3I
Description		importin 13	eukaryotic translation initiation factor 3 subunit I
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GO Annotations	Cellular Component	Nucleus Cytoplasm	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Synapse Extracellular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3m
	Molecular Function	Protein Binding Small GTPase Binding	RNA Binding Translation Initiation Factor Activity Protein Binding
	Biological Process	Protein Import Into Nucleus Intracellular Protein Transport Protein Transport	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translation Translational Initiation
Pathways			L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026)
Interacting Genes		30 interacting genes: ALX1 ARX CDK1 CRX EIF1AX EIF2B3 EIF3I EIF4B GK HMBOX1 KDM4A MAGOH MAST2 NOSIP NPSR1 NUP50 PAX3 PAX6 PBX4 PIK3R3 PITX1 PPFIA2 PPIH PREX1 PSMA1 RAN RBM8A RNF10 RPL5 UBE2I	16 interacting genes: EIF3A EIF3B EIF4G1 ERCC6 ESR1 EXOSC6 IPO13 KDM4A LIG4 METTL3 NEDD8 PAXIP1 SUMO4 TGFB1 TGFBR2 UBC
Entrez ID		9670	8668
HPRD ID		13742	04884
Ensembl ID		ENSG00000117408	ENSG00000084623
Uniprot IDs		O94829	A0A7I2YQI2 Q13347 Q5U0F4
PDB IDs		2X19 2XWU 3ZJY	6YBT 6ZMW 6ZON 6ZP4 6ZVJ 7A09 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8XXN 9BLN
Enriched GO Terms of Interacting Partners?		Translation Initiation Factor Activity Chromatin Translational Initiation Exon-exon Junction Subcomplex Mago-y14 Cytosol Sequence-specific Double-stranded DNA Binding Nuclear Export Nuclear Transport Nucleocytoplasmic Transport RNA Transport RNA Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Neuron Development Translation Eukaryotic 48S Preinitiation Complex Eukaryotic 43S Preinitiation Complex RNA Export From Nucleus Nuclear Pore Nucleobase-containing Compound Transport Translation Factor Activity, RNA Binding Exon-exon Junction Complex Cell Development Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Nucleoplasm Pronuclear Fusion Regulation Of Macromolecule Metabolic Process Microtubule Cytoskeleton Organization Involved In Mitosis Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Chromatin Binding Cytoplasm Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Glycerol Kinase Activity Glycerol-3-phosphate Biosynthetic Process MRNA Transport Sequence-specific DNA Binding Forebrain-midbrain Boundary Formation Pituitary Gland Development Pancreatic A Cell Development SUMO Conjugating Enzyme Activity Structural Constituent Of Presynapse Cytoplasmic Translational Initiation	Protein Tag Activity Positive Regulation Of DNA Recombination Cytoplasmic Translational Initiation Regulation Of DNA Recombination Response To Ionizing Radiation Regulation Of Isotype Switching Positive Regulation Of Isotype Switching Positive Regulation Of Immunoglobulin Mediated Immune Response Type III Transforming Growth Factor Beta Receptor Binding Langerhans Cell Differentiation Viral Translational Termination-reinitiation Translation Initiation Factor Activity Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Macromolecule Metabolic Process Eukaryotic Translation Initiation Factor 3 Complex, EIF3m Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Immunoglobulin Production Vasculogenesis Connective Tissue Development Response To Radiation Double-strand Break Repair Via Classical Nonhomologous End Joining Single Strand Break Repair Type I Transforming Growth Factor Beta Receptor Binding IRES-dependent Viral Translational Initiation Regulation Of Immunoglobulin Production Translational Initiation Branch Elongation Of An Epithelium Respiratory Tube Development Positive Regulation Of B Cell Activation Formation Of Cytoplasmic Translation Initiation Complex Regulation Of Fibroblast Proliferation Regulation Of Lymphocyte Activation Eukaryotic Translation Initiation Factor 3 Complex Regulation Of Gene Expression Eukaryotic 48S Preinitiation Complex Positive Regulation Of DNA Metabolic Process Eukaryotic 43S Preinitiation Complex Regulation Of Translational Initiation Regulation Of Macromolecule Biosynthetic Process Axis Elongation Branching Involved In Mammary Gland Duct Morphogenesis Neurogenesis Macromolecule Biosynthetic Process Myeloid Dendritic Cell Differentiation Translation Initiation Factor Binding Regulation Of Protein Metabolic Process Branching Morphogenesis Of An Epithelial Tube Isotype Switching Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Positive Regulation Of Lymphocyte Mediated Immunity
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