PPM1F and ARHGEF7

Number of citations of the paper that reports this interaction (PubMedID 11864573)
0

Data Source:
HPRD (in vivo)

		PPM1F	ARHGEF7
Description		protein phosphatase, Mg2+/Mn2+ dependent 1F	Rho guanine nucleotide exchange factor 7
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Protein-containing Complex Perinuclear Region Of Cytoplasm	Ruffle Cytoplasm Centrosome Cytosol Focal Adhesion Cell Cortex Lamellipodium Protein-containing Complex Cell Projection Neuron Projection Neuronal Cell Body Anchoring Junction Mitotic Spindle Pole Postsynapse
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Hydrolase Activity Calmodulin-dependent Protein Phosphatase Activity Cation Binding Metal Ion Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Kinase Binding Gamma-tubulin Binding
	Biological Process	Apoptotic Process Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Cell Migration Regulation Of Protein Localization Intracellular Signal Transduction Negative Regulation Of DNA-templated Transcription Positive Regulation Of Growth Positive Regulation Of Chemotaxis Negative Regulation Of Protein Transport Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Cellular Response To Xenobiotic Stimulus Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin	Golgi Organization Signal Transduction Rho Protein Signal Transduction Nervous System Development Positive Regulation Of Fibroblast Migration Lamellipodium Assembly Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Focal Adhesion Assembly Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Microtubule Nucleation Positive Regulation Of Lamellipodium Morphogenesis
Pathways		Negative regulation of NMDA receptor-mediated neuronal transmission	EGFR downregulation NRAGE signals death through JNK Ephrin signaling G alpha (12/13) signalling events RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RHOV GTPase cycle
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Attention deficit hyperactivity disorder ( 18839057) Bipolar disorder ( 31043756)	Bilirubin levels ( 19414484) Choroid plexus volume ( 31530798) Fasting insulin (dietary factor interaction) ( 24204828) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) Macular thickness ( 30535121) Menarche (age at onset) ( 21102462) Menopause (age at onset) ( 19448619) Skin aging measurement ( 31522824) Weight ( 34074324)
Interacting Genes		21 interacting genes: AATK ARHGEF7 CAMK2A ERBB2 ERBB3 ERBB4 FAM161A FEM1A FEM1B KLHL8 LATS1 LMTK2 MARS1 MEOX1 OGT PAK1 PRKAA1 PTK7 ROR1 ROR2 WEE2-AS1	37 interacting genes: ADAM15 ARHGEF6 CALM1 CBLB CD244 CDC42 EGFR ERBIN FXR1 FXR2 GIT1 GIT2 HSPB1 ITCH LRRK2 MEOX2 NCK1 NCKIPSD NOX1 PAK1 PAK2 PAK3 PPM1E PPM1F PRKCG PRRG4 PXN RAC1 SCRIB SH2D1A SHANK1 SHANK2 TGFBR2 TUBB3 VHL WAS YWHAG
Entrez ID		9647	8874
HPRD ID		10163	05688
Ensembl ID		ENSG00000100034	ENSG00000102606
Uniprot IDs		B5MCT7 P49593	A0A2R8YG42 A0A8V8TQ72 B1ALK7 B7Z344 B7Z6G2 E9PDQ5 Q14155
PDB IDs			1BY1 1ZSG 2L3G 5SXP
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Kinase Activity ATP Binding Nucleotide Binding Transferase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Coreceptor Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ERBB3:ERBB2 Complex Wound Healing ERBB2 Signaling Pathway Protein Serine Kinase Activity Receptor Complex Neuregulin Receptor Activity Positive Regulation Of Signal Transduction Protein Serine/threonine Kinase Activity Protein Modification Process Enzyme-linked Receptor Protein Signaling Pathway ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction Response To Epidermal Growth Factor Regulation Of Catalytic Activity Protein Phosphorylation Cell Surface Receptor Signaling Pathway ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Mesenchyme Development Epidermal Growth Factor Receptor Signaling Pathway Apoptotic Process Glial Cell Development Regulation Of Protein Localization Basal Plasma Membrane Phosphorylation Cell Death Programmed Cell Death Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Regulation Of Insulin Receptor Signaling Pathway Axon Response To Wounding ERBB Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Fibroblast Migration Regulation Of Organ Growth	Regulation Of Signaling Regulation Of Actin Filament Organization Regulation Of Supramolecular Fiber Organization Regulation Of Stress Fiber Assembly Postsynapse Regulation Of Cell Communication Regulation Of Actin Cytoskeleton Organization Regulation Of Signal Transduction Regulation Of Actin Filament-based Process Cell-cell Junction Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Regulation Of Cytoskeleton Organization Signal Transduction Glutamatergic Synapse Positive Regulation Of Stress Fiber Assembly Regulation Of Cellular Component Organization Positive Regulation Of Supramolecular Fiber Organization Cell Surface Receptor Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Cytoskeleton Organization Focal Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Plasma Membrane Modulation Of Chemical Synaptic Transmission Enzyme-linked Receptor Protein Signaling Pathway Cell Projection Small GTPase Binding SH3 Domain Binding Lamellipodium Regulation Of Synaptic Plasticity Cytosol Positive Regulation Of Signaling Regulation Of Biological Quality Regulation Of Multicellular Organismal Process Regulation Of Immune System Process Dendrite Neuron Projection Regulation Of Organelle Organization Cytoplasm Regulation Of Protein Modification Process Positive Regulation Of Immune System Process Regulation Of MAPK Cascade Positive Regulation Of Organelle Organization Protein Localization To Cell Junction Postsynaptic Density Positive Regulation Of T Cell Tolerance Induction Intracellular Signaling Cassette Regulation Of Protein Metabolic Process Regulation Of Locomotion
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