CD48 and MAST2

		CD48	MAST2
Description		CD48 molecule	microtubule associated serine/threonine kinase 2
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Membrane Raft Extracellular Exosome Side Of Membrane	Cytoplasm Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Membrane
	Molecular Function	Protein Binding Receptor Ligand Activity	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Kinase Activity Transferase Activity Phosphatase Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Defense Response Immune Response Signal Transduction Natural Killer Cell Activation Leukocyte Activation	Protein Phosphorylation Cytoskeleton Organization Regulation Of Interleukin-12 Production Intracellular Signal Transduction Spermatid Differentiation
Pathways		Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Inflammatory bowel disease ( 23128233) Itch intensity from mosquito bite ( 28199695) Multiple sclerosis ( 31604244) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Body mass index ( 25673413) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Granulocyte count ( 27863252) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin saturation) ( 28334935) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Red blood cell count ( 27863252 32888494) Reticulocyte count ( 32888494 27863252) Serum metabolite levels ( 33031748) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Sum basophil neutrophil counts ( 27863252) Type 2 diabetes ( 32499647)
Interacting Genes		10 interacting genes: BRIX1 CD2 CD244 CD247 EEF1D FYN GNAI3 IL18R1 IL18RAP LCK	27 interacting genes: ACE2 ACTN2 APP CDHR2 DYNLL1 MXRA7 PTEN RPS27A RPS6KA1 SH3GL2 SLC34A1 SLC9A3 SMN1 SNTB2 SRPK2 STK36 SUMO2 TK1 TPM1 TPM2 TPM3 TRAF2 TRAF6 TTN USP7 VANGL2 ZNF417
Entrez ID		962	23139
HPRD ID		00177	11294
Ensembl ID		ENSG00000117091	ENSG00000086015
Uniprot IDs		A0A087X1S7 P09326	A0A669KBJ4 Q6P0Q8
PDB IDs		2EDO	2KQF 2KYL
Enriched GO Terms of Interacting Partners?		Leukocyte Activation Natural Killer Cell Activation Cell Activation Lymphocyte Activation T Cell Activation Adaptive Immune Response Interleukin-18 Receptor Complex Interleukin-18 Receptor Activity Ephrin Receptor Binding Fc-gamma Receptor Signaling Pathway CD8 Receptor Binding Signaling Receptor Activity Ephrin Receptor Signaling Pathway Fc Receptor Signaling Pathway CD4 Receptor Binding Plasma Membrane Phospholipase Activator Activity Positive Regulation Of Type II Interferon Production T Cell Receptor Binding Positive Regulation Of Immune System Process Interleukin-18-mediated Signaling Pathway NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Signal Transduction Phosphatidylinositol 3-kinase Binding Cell Surface Receptor Signaling Pathway Immune Response T Cell Receptor Signaling Pathway Gamma-delta T Cell Activation Phospholipase Binding Regulation Of Type II Interferon Production Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Vasculature Development Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Positive Regulation Of Metabolic Process Antigen Receptor-mediated Signaling Pathway Immune System Process Regulation Of Multicellular Organismal Process Positive Regulation Of Immune Response Immune Effector Process Signaling Receptor Binding Cellular Response To Glycine Response To Singlet Oxygen Non-membrane Spanning Protein Tyrosine Kinase Activity Cellular Response To Interleukin-18 Positive Regulation Of Macromolecule Metabolic Process T Cell Costimulation Regulation Of Metabolic Process Regulation Of Immune System Process	Muscle Thin Filament Tropomyosin Identical Protein Binding Structural Constituent Of Muscle Brush Border Membrane Actin Filament Actin Filament Binding Cellular Component Assembly Cytosol Apical Plasma Membrane Sarcomere Organization Enzyme Binding Muscle System Process Cell Projection Organization Plasma Membrane Bounded Cell Projection Organization Actin Cytoskeleton CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Negative Regulation Of Smooth Muscle Cell Proliferation Brush Border CD40 Receptor Complex TORC1 Signaling Positive Regulation Of JUN Kinase Activity Organelle Assembly Cytoskeletal Protein Binding Regulation Of Transport Regulation Of Biological Quality Protein Tag Activity Muscle Tissue Morphogenesis Muscle Filament Sliding Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Intracellular Signal Transduction Postsynaptic Actin Cytoskeleton Organization Actin-myosin Filament Sliding PDZ Domain Binding TOR Signaling Muscle Contraction Stress Fiber Actin Binding Response To Lead Ion Membrane Raft Postsynaptic Cytoskeleton Organization Presynapse System Process Sodium Ion Import Across Plasma Membrane Cardiac Muscle Hypertrophy Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Localization Protein Metabolic Process Cytoplasmic Side Of Plasma Membrane PML Body
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