MAST2 and TPM2

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		MAST2	TPM2
Description		microtubule associated serine/threonine kinase 2	tropomyosin 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Membrane	Cytoplasm Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Actin Filament Actin Cytoskeleton
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Kinase Activity Transferase Activity Phosphatase Binding Metal Ion Binding Protein Serine Kinase Activity	Actin Binding Protein Binding Structural Constituent Of Muscle Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Actin Filament Binding
	Biological Process	Protein Phosphorylation Cytoskeleton Organization Regulation Of Interleukin-12 Production Intracellular Signal Transduction Spermatid Differentiation	Muscle Contraction Actin Filament Organization Regulation Of ATP-dependent Activity
Pathways			Striated Muscle Contraction Smooth Muscle Contraction
Drugs
Diseases			Cap myopathy Distal arthrogryposis (DA) Nemaline myopathy
GWAS		Body mass index ( 25673413) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Granulocyte count ( 27863252) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin saturation) ( 28334935) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Red blood cell count ( 27863252 32888494) Reticulocyte count ( 32888494 27863252) Serum metabolite levels ( 33031748) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Sum basophil neutrophil counts ( 27863252) Type 2 diabetes ( 32499647)	Immature fraction of reticulocytes ( 32888494) Platelet count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		31 interacting genes: ACE2 ACTN2 APP CD200 CD48 CDHR2 DYNLL1 IPO13 KDM4A MXRA7 PTEN RPS27A RPS6KA1 SH3GL2 SLC34A1 SLC9A3 SMN1 SNTB2 SRPK2 STK36 SUMO2 TK1 TPM1 TPM2 TPM3 TRAF2 TRAF6 TTN USP7 VANGL2 ZNF417	22 interacting genes: ABI2 ACTA1 ACTB FARS2 GRK2 JUN MAST2 MESD MRFAP1 NEB PDLIM7 PIK3CG RRAD S100A2 S100A4 SKIL SNAPIN TFPT TPM1 ZNF229 ZNF620 ZNF785
Entrez ID		23139	7169
HPRD ID		11294	11768
Ensembl ID		ENSG00000086015	ENSG00000198467
Uniprot IDs		A0A669KBJ4 Q6P0Q8	A7XZE4 P07951 Q5TCU3 V9HW25
PDB IDs		2KQF 2KYL
Enriched GO Terms of Interacting Partners?		Muscle Thin Filament Tropomyosin Identical Protein Binding Structural Constituent Of Muscle Brush Border Membrane Actin Filament Actin Filament Binding Cellular Component Assembly Cytosol Apical Plasma Membrane Sarcomere Organization Enzyme Binding Muscle System Process Cell Projection Organization Plasma Membrane Bounded Cell Projection Organization Actin Cytoskeleton CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Negative Regulation Of Smooth Muscle Cell Proliferation Brush Border CD40 Receptor Complex TORC1 Signaling Positive Regulation Of JUN Kinase Activity Organelle Assembly Cytoskeletal Protein Binding Regulation Of Transport Regulation Of Biological Quality Protein Tag Activity Muscle Tissue Morphogenesis Muscle Filament Sliding Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Intracellular Signal Transduction Postsynaptic Actin Cytoskeleton Organization Actin-myosin Filament Sliding PDZ Domain Binding TOR Signaling Muscle Contraction Stress Fiber Actin Binding Response To Lead Ion Membrane Raft Postsynaptic Cytoskeleton Organization Presynapse System Process Sodium Ion Import Across Plasma Membrane Cardiac Muscle Hypertrophy Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Localization Protein Metabolic Process Cytoplasmic Side Of Plasma Membrane PML Body	Actin Filament Actin Cytoskeleton Sarcomere Negative Regulation Of Striated Muscle Contraction Stress Fiber Adherens Junction Assembly Identical Protein Binding Structural Constituent Of Cytoskeleton Actin Filament Organization Negative Regulation Of Muscle Contraction Negative Regulation Of Heart Contraction Transition Metal Ion Binding Negative Regulation Of Blood Circulation
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