CD48 and DIO1

		CD48	DIO1
Description		CD48 molecule	iodothyronine deiodinase 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Membrane Raft Extracellular Exosome Side Of Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Basolateral Plasma Membrane
	Molecular Function	Protein Binding Receptor Ligand Activity	Thyroxine 5'-deiodinase Activity Selenium Binding Oxidoreductase Activity Thyroxine 5-deiodinase Activity
	Biological Process	Defense Response Immune Response Signal Transduction Natural Killer Cell Activation Leukocyte Activation	Amino Acid Metabolic Process Thyroid Hormone Generation Thyroid Hormone Metabolic Process Thyroid Hormone Catabolic Process Hormone Biosynthetic Process
Pathways		Cell surface interactions at the vascular wall	Regulation of thyroid hormone activity
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Inflammatory bowel disease ( 23128233) Itch intensity from mosquito bite ( 28199695) Multiple sclerosis ( 31604244) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Free thyroxine concentration ( 25743335) Serum metabolite concentrations in chronic kidney disease ( 33838163) Thyroid hormone levels ( 23408906)
Interacting Genes		20 interacting genes: ACKR1 BRIX1 CD2 CD244 CD247 DIO1 E2F2 EEF1D EFNA1 EFNA3 FYN GNAI3 IL18R1 IL18RAP KPLCE LCK LY9 MAST2 OAZ3 P4HA1	2 interacting genes: ARTN CD48
Entrez ID		962	1733
HPRD ID		00177	01002
Ensembl ID		ENSG00000117091	ENSG00000211452
Uniprot IDs		A0A087X1S7 P09326	A8K415 P49895
PDB IDs		2EDO
Enriched GO Terms of Interacting Partners?		Leukocyte Activation Natural Killer Cell Activation Cell Activation Lymphocyte Activation T Cell Activation Adaptive Immune Response Interleukin-18 Receptor Complex Interleukin-18 Receptor Activity Ephrin Receptor Binding Fc-gamma Receptor Signaling Pathway CD8 Receptor Binding Signaling Receptor Activity Ephrin Receptor Signaling Pathway Fc Receptor Signaling Pathway CD4 Receptor Binding Plasma Membrane Phospholipase Activator Activity Positive Regulation Of Type II Interferon Production T Cell Receptor Binding Positive Regulation Of Immune System Process Interleukin-18-mediated Signaling Pathway NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Signal Transduction Phosphatidylinositol 3-kinase Binding Cell Surface Receptor Signaling Pathway Immune Response T Cell Receptor Signaling Pathway Gamma-delta T Cell Activation Phospholipase Binding Regulation Of Type II Interferon Production Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Vasculature Development Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Positive Regulation Of Metabolic Process Antigen Receptor-mediated Signaling Pathway Immune System Process Regulation Of Multicellular Organismal Process Positive Regulation Of Immune Response Immune Effector Process Signaling Receptor Binding Cellular Response To Glycine Response To Singlet Oxygen Non-membrane Spanning Protein Tyrosine Kinase Activity Cellular Response To Interleukin-18 Positive Regulation Of Macromolecule Metabolic Process T Cell Costimulation Regulation Of Metabolic Process Regulation Of Immune System Process	Glial Cell-derived Neurotrophic Factor Receptor Binding Peyer's Patch Morphogenesis Lymphocyte Migration Into Lymphoid Organs Induction Of Positive Chemotaxis Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Positive Chemotaxis Peripheral Nervous System Development Natural Killer Cell Activation Neuroblast Proliferation Lymphocyte Migration Receptor Tyrosine Kinase Binding
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