NCOR2 and CEBPB

Number of citations of the paper that reports this interaction (PubMedID 15870285)
40

Data Source:
BioGRID (pull down)

		NCOR2	CEBPB
Description		nuclear receptor corepressor 2	CCAAT enhancer binding protein beta
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Membrane Nuclear Matrix Nuclear Body Transcription Repressor Complex Protein-containing Complex	Condensed Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Matrix CHOP-C/EBP Complex RNA Polymerase II Transcription Regulator Complex C/EBP Complex
	Molecular Function	DNA Binding Chromatin Binding Transcription Corepressor Activity Notch Binding Protein Binding Enzyme Activator Activity Nuclear Receptor Binding Nuclear Glucocorticoid Receptor Binding Histone Deacetylase Binding Nuclear Retinoic Acid Receptor Binding Protein-containing Complex Binding Nuclear Retinoid X Receptor Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Kinase Binding Chromatin DNA Binding Histone Acetyltransferase Binding Nuclear Glucocorticoid Receptor Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding Ubiquitin-like Protein Ligase Binding Protein Heterodimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Lactation Regulation Of Ketone Metabolic Process Cerebellum Development Response To Estradiol Estrous Cycle Negative Regulation Of DNA-templated Transcription Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of MiRNA Transcription	Negative Regulation Of Transcription By RNA Polymerase II Ovarian Follicle Development Liver Development Embryonic Placenta Development Granuloma Formation DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Acute-phase Response Inflammatory Response Immune Response Memory Positive Regulation Of Gene Expression Cell Differentiation Neuron Differentiation Response To Lipopolysaccharide Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-4 Production Mammary Gland Epithelial Cell Proliferation Response To Endoplasmic Reticulum Stress T-helper 1 Cell Activation Negative Regulation Of T Cell Proliferation Defense Response To Bacterium Negative Regulation Of Neuron Apoptotic Process Fat Cell Differentiation Regulation Of Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Regulation Of Osteoclast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Inflammatory Response Brown Fat Cell Differentiation Mammary Gland Epithelial Cell Differentiation Myeloid Cell Development Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Biomineral Tissue Development Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Cellular Response To Interleukin-1 Hepatocyte Proliferation Liver Regeneration Positive Regulation Of Cold-induced Thermogenesis Integrated Stress Response Signaling Regulation Of Odontoblast Differentiation Positive Regulation Of Sodium-dependent Phosphate Transport Regulation Of Dendritic Cell Differentiation
Pathways		PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway SUMOylation of transcription cofactors Regulation of lipid metabolism by PPARalpha Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis Cytoprotection by HMOX1 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) ATF4 activates genes in response to endoplasmic reticulum stress Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Transcriptional Regulation by VENTX Transcriptional regulation of granulopoiesis Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency Response of EIF2AK1 (HRI) to heme deficiency Nuclear events stimulated by ALK signaling in cancer
Drugs			Quercetin
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) ( 23648065) Appendicular lean mass ( 33097823) Clubfoot ( 24667120) Cocaine dependence ( 23958962) Cognitive performance ( 19734545) Diastolic blood pressure ( 30224653) HDL cholesterol levels ( 32203549) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Lung function (FEV1) ( 30061609) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244) Platelet distribution width ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Bronchodilator response in asthma ( 25562107) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 23128233) Meconium ileus in cystic fibrosis ( 30807572) Pancreas fat ( 34128465) Type 2 diabetes ( 30297969 30718926 32499647)
Interacting Genes		94 interacting genes: ADRB2 AHR AKT1 AP2M1 AR ARNT ATXN1 ATXN1L BCL6 C1D CAMK2B CBFA2T2 CDK2 CEBPB CEP63 CHUK CIRSR CNOT2 DDX20 E2F1 ESR1 ESR2 FOS FOXP1 H4C1 HDAC1 HDAC10 HDAC3 HDAC4 HDAC5 HDAC7 HNF4A INPP5K IRF5 JUN KLF5 KPNA4 MYBL2 MYOD1 NCOA3 NCOA6 NCOR1 NFE2L2 NFKB1 NFKBIA NFKBIB NFKBIE NR1D1 NR1H2 NR1H4 NR1I2 NR2F1 NR2F2 NR3C1 NR4A1 PIN1 PML POU2F1 PPARA PPARD PPARG PTPN11 RANBP9 RARA RARB RARG RBPJ RELA RUNX1 RUNX1T1 RXRA RXRG SAP30 SH2B3 SKIL SNW1 SP1 SPEN SRF STAT5A STAT5B SUMO1 TBL1X THRA THRB TNIK TNIP2 UBC UBE2I VDR YWHAE ZBTB16 ZBTB5 ZBTB7A	58 interacting genes: AR ATF2 ATF4 CAMK2A CCL3 CEBPA CEBPD CEBPG CREB1 CREBBP DDIT3 DMAP1 EGFR EGR1 ELK1 EP300 ESR1 FOXO1 HMGA1 HMGB1 HNRNPK HOMER3 HSF1 KAT2A KAT2B MAPK1 MAPK3 MED20 MED23 MYB MYC NCOR2 NFKB1 NOLC1 NR3C1 NUP50 PTGES2 RARB RB1 RELA RPS6KA1 RPS6KA5 RUNX1 RUNX2 SMAD3 SMAD4 SMARCA4 SMARCB1 SMARCC1 SP1 SPI1 SPIB SRF STAT5A STAT6 TAF9 TRIB1 TRIM28
Entrez ID		9612	1051
HPRD ID		02910	01801
Ensembl ID		ENSG00000196498	ENSG00000172216
Uniprot IDs		C9J0Q5 C9JE98 Q9Y618	P17676
PDB IDs		1KKQ 1R2B 1XC5 2GPV 2L5G 2LTP 2ODD 2RT5 3R29 3R2A 4A69 4OAR 5X8Q 5X8X 5ZOO 5ZOP 6A22 6IVX 6PDZ 7SQA 8AQM 8AQN 8B8W 8B8X 8B8Y 8B8Z 8B90 8B91 8B92 8B93 8B94 8B95 8X7E	1GTW 1GU4 1GU5 1H88 1H89 1H8A 1HJB 1IO4 2E42 2E43 6MG1 6MG2 6MG3 7L4V 7UPZ 8K8D
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Nuclear Receptor Activity Positive Regulation Of Transcription By RNA Polymerase II Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Intracellular Receptor Signaling Pathway DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nucleus DNA Binding Chromatin Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Metabolic Process RNA Polymerase II Transcription Regulator Complex DNA-templated Transcription Hormone-mediated Signaling Pathway Retinoic Acid Receptor Signaling Pathway Intracellular Signal Transduction Cell Differentiation Transcription Cis-regulatory Region Binding Regulation Of Multicellular Organismal Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding Transcription By RNA Polymerase II	Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Nucleoplasm Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process DNA Binding DNA-binding Transcription Factor Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Chromatin Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Biosynthetic Process Regulation Of MiRNA Metabolic Process Nucleus RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific DNA Binding Regulation Of MiRNA Transcription Transcription Cis-regulatory Region Binding Positive Regulation Of MiRNA Metabolic Process Regulation Of Multicellular Organismal Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of MiRNA Transcription Regulation Of Cell Differentiation Regulation Of Developmental Process DNA-templated Transcription Positive Regulation Of Multicellular Organismal Process
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