CYTIP and CYTH2

Number of citations of the paper that reports this interaction (PubMedID 12606567)
43

Data Source:
HPRD (in vitro)

		CYTIP	CYTH2
Description		cytohesin 1 interacting protein	cytohesin 2
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Cell Cortex	Golgi Membrane Cytoplasm Cytosol Plasma Membrane Adherens Junction Bicellular Tight Junction Membrane Growth Cone Cell Projection Anchoring Junction
	Molecular Function	Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Lipid Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Regulation Of Cell Adhesion	Endocytosis Actin Cytoskeleton Organization Regulation Of ARF Protein Signal Transduction
Pathways			Intra-Golgi traffic
Drugs			Inositol 1,3,4,5-Tetrakisphosphate Formic acid 1D-myo-inositol 1,4,5-trisphosphate S,S-(2-Hydroxyethyl)Thiocysteine Brefeldin A
Diseases
GWAS		Type 2 diabetes ( 30297969) Urate levels ( 31578528)	Abstraction and mental flexibility ( 31596458)
Interacting Genes		9 interacting genes: ARX CYTH1 CYTH2 CYTH3 KIF9 MCRS1 SCNM1 SHANK3 SOCS1	32 interacting genes: ADORA2A ALDOA APC ARF1 ARF6 ARFGAP1 ARL4A ARL4D ARRB1 ARRB2 ATP6V0A1 ATP6V0A2 ATP6V0A4 CCDC120 CUX1 CYTIP DOCK1 GGA3 GNAQ IPCEF1 ITGB2 MAPK6 NUP62 PIK3CA PNPLA2 PRKCA PRKCB PRKCG PRRG2 SNCA TCIRG1 TRIM23
Entrez ID		9595	9266
HPRD ID		09192	03925
Ensembl ID		ENSG00000115165	ENSG00000105443
Uniprot IDs		O60759	Q99418
PDB IDs		2Z17	1PBV 1R8M 1R8Q 1R8S 1S9D 4JMI 4JMO 4JWL 4JXH 4L5M 4Z21
Enriched GO Terms of Interacting Partners?		Regulation Of ARF Protein Signal Transduction Bicellular Tight Junction Establishment Of Epithelial Cell Polarity Adherens Junction Guanyl-nucleotide Exchange Factor Activity Regulation Of Small GTPase Mediated Signal Transduction Lipid Binding Anchoring Junction Establishment Of Cell Polarity Guanylate Kinase-associated Protein Clustering Embryonic Olfactory Bulb Interneuron Precursor Migration	Vesicle-mediated Transport Proton-transporting V-type ATPase, V0 Domain Vacuolar Proton-transporting V-type ATPase, V0 Domain Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Biological Quality Plasma Membrane Vacuolar Proton-transporting V-type ATPase Complex Proton-transporting V-type ATPase Complex Regulation Of Vesicle-mediated Transport Proton-transporting ATPase Activity, Rotational Mechanism Vacuolar Acidification Endocytosis Positive Regulation Of Protein Localization Intracellular Protein Localization Regulation Of Endocytosis Cellular Homeostasis Membrane Protein Transport Intracellular PH Reduction Angiotensin Receptor Binding Histone H3T6 Kinase Activity Regulation Of Protein Localization Diacylglycerol-dependent Serine/threonine Kinase Activity Lysosomal Membrane Intracellular Chemical Homeostasis Regulation Of Secretion By Cell Receptor Internalization Establishment Of Protein Localization Import Into Cell Endosome Membrane Regulation Of Transport Regulation Of Secretion Phagocytic Vesicle Membrane Positive Regulation Of Secretion By Cell ATPase Binding Regulation Of Intracellular PH Regulation Of Neurotransmitter Secretion Chemical Homeostasis Negative Regulation Of Dopamine Metabolic Process Protein Kinase C Signaling Regulation Of Cellular PH Monoatomic Cation Homeostasis Positive Regulation Of Secretion GTPase Activity Regulation Of Exocytosis Apoptotic Process Monoatomic Ion Homeostasis Phagocytosis Regulation Of PH Negative Regulation Of Catecholamine Metabolic Process
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