RAB3D and MAST1

Number of citations of the paper that reports this interaction (PubMedID 21163940)
58

Data Source:
BioGRID (two hybrid)

		RAB3D	MAST1
Description		RAB3D, member RAS oncogene family	microtubule associated serine/threonine kinase 1
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GO Annotations	Cellular Component	Endosome Cytoplasmic Microtubule Plasma Membrane Synaptic Vesicle Membrane Secretory Granule Azurophil Granule Membrane Zymogen Granule Extracellular Exosome Secretory Vesicle	Cytoplasm Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Membrane Axon Dendrite Cell Projection Neuron Projection Neuronal Cell Body
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GTP-dependent Protein Binding Myosin V Binding Metal Ion Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Exocytosis Protein Transport Regulation Of Exocytosis Bone Resorption Positive Regulation Of Regulated Secretory Pathway	Protein Phosphorylation Cytoskeleton Organization Brain Development Developmental Process Intracellular Signal Transduction
Pathways		Neutrophil degranulation RAB geranylgeranylation
Drugs			Fostamatinib
Diseases
GWAS		Early cardiac repolarization ( 31600170) HDL cholesterol ( 23505323)	High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Intelligence (MTAG) ( 29326435) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252 32888494) Red blood cell count ( 29403010) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		16 interacting genes: AKT1 AKT2 AP1M2 APP CEP55 CHM CYP2C9 MAST1 RAB3IP RABIF REP15 RIMS2 RNF32 RPH3AL SYTL4 VRTN	41 interacting genes: A2M ACE2 AP1M2 APOE APP BLMH CDK5 CYP2C8 CYP2C9 DNAJB1 ECSIT EGFR ELAVL3 EXOC6 EXOSC1 FBXL12 FBXW4 GCDH IFIT3 IFIT5 LONP1 LOXL4 NOS3 OGA PAXIP1 PRAM1 PRDX2 PSEN2 PTEN RAB3A RAB3D RAD23A RNF32 RNLS RPP30 RPS6KA1 SNTA1 SNTB2 STAMBPL1 TIAM1 VANGL2
Entrez ID		9545	22983
HPRD ID		05070	17469
Ensembl ID		ENSG00000105514	ENSG00000105613
Uniprot IDs		A0A024R7G2 O95716	Q9Y2H9
PDB IDs		2GF9	2M9X 3PS4
Enriched GO Terms of Interacting Partners?		Establishment Of Protein Localization Protein Transport Vesicle-mediated Transport Intracellular Protein Localization Cellular Localization Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Intracellular Protein Transport Negative Regulation Of Fatty Acid Transport Regulation Of Long-chain Fatty Acid Import Into Cell Peripheral Nervous System Myelin Maintenance Intracellular Transport Negative Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Response To Endoplasmic Reticulum Stress Myelin Maintenance Mammary Gland Epithelial Cell Differentiation Post-Golgi Vesicle-mediated Transport Glycogen Biosynthetic Process Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Vesicle-mediated Transport Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Glycogen Biosynthetic Process Small GTPase Binding Plasma Membrane Organization Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Establishment Of Protein Localization Protein Localization To Extracellular Region Establishment Of Protein Localization To Extracellular Region Protein Secretion Polysaccharide Biosynthetic Process Membrane Organization Regulation Of Generation Of Precursor Metabolites And Energy Molecular Function Activator Activity Establishment Of Localization In Cell Regulation Of Glycogen Biosynthetic Process Regulation Of Fatty Acid Transport Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Excitatory Postsynaptic Potential Secretion By Cell Regulation Of Fatty Acid Oxidation Endosome Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of D-glucose Import Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Lipid Transport Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Glycogen Metabolic Process Positive Regulation Of Protein Localization Positive Regulation Of Nitric Oxide Metabolic Process Regulation Of Exocytosis Positive Regulation Of Transport	Lipoprotein Particle Acetylcholine Receptor Activator Activity Negative Regulation Of Smooth Muscle Cell Proliferation Caffeine Oxidase Activity Intermediate-density Lipoprotein Particle Positive Regulation Of Amyloid Fibril Formation Chemical Synaptic Transmission Catabolic Process Cytosol Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Trans-synaptic Signaling Oxidative Demethylation Synaptic Signaling Cellular Response To Amyloid-beta Positive Regulation Of Regulated Secretory Pathway Regulation Of Regulated Secretory Pathway Omega-hydroxylase P450 Pathway Oxidoreductase Activity Arachidonate Epoxygenase Activity Regulation Of Neuronal Synaptic Plasticity Regulation Of Wound Healing Negative Regulation Of Long-term Synaptic Potentiation Regulation Of System Process Regulation Of Blood Circulation Demethylation Regulation Of Dendritic Spine Maintenance Response To Amyloid-beta Regulation Of Smooth Muscle Cell Proliferation Learning Or Memory Axonogenesis Epoxygenase P450 Pathway Low-density Lipoprotein Particle Removal Of Superoxide Radicals Negative Regulation Of Wound Healing Regulation Of Blood Coagulation Positive Regulation Of Membrane Protein Ectodomain Proteolysis Myosin V Binding Dystrophin-associated Glycoprotein Complex Regulation Of Hemostasis Heparan Sulfate Proteoglycan Binding Intracellular Signaling Cassette Regulation Of Amyloid Fibril Formation Regulation Of Response To Wounding Negative Regulation Of Platelet Activation Cognition Cellular Oxidant Detoxification Regulation Of Transport Ubiquitin-specific Protease Binding Very-low-density Lipoprotein Particle Regulation Of Amyloid-beta Clearance
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