GOSR1 and NSF

Number of citations of the paper that reports this interaction (PubMedID 8636227)
44

Data Source:
HPRD (in vivo)

		GOSR1	NSF
Description		golgi SNAP receptor complex member 1	N-ethylmaleimide sensitive factor, vesicle fusing ATPase
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Golgi Medial Cisterna Cis-Golgi Network Cytosol Membrane Transport Vesicle SNARE Complex	Cytoplasm Lysosomal Membrane Golgi Apparatus Golgi Stack Cytosol Plasma Membrane Dendritic Shaft GABA-ergic Synapse Postsynaptic Specialization, Intracellular Component
	Molecular Function	SNAP Receptor Activity	SNARE Binding Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Syntaxin-1 Binding Protein Kinase Binding Syntaxin Binding PDZ Domain Binding Ionotropic Glutamate Receptor Binding Protein-containing Complex Binding Metal Ion Binding ATP-dependent Protein Disaggregase Activity
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport Vesicle Fusion Protein Transport Vesicle-mediated Transport Retrograde Transport, Endosome To Golgi Inter-Golgi Cisterna Vesicle-mediated Transport	Positive Regulation Of Receptor Recycling Potassium Ion Transport Intracellular Protein Transport Exocytosis Intra-Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport Regulation Of Exocytosis SNARE Complex Disassembly Golgi To Plasma Membrane Protein Transport Plasma Membrane Fusion Positive Regulation Of Protein Catabolic Process
Pathways		COPI-mediated anterograde transport Intra-Golgi traffic	COPII-mediated vesicle transport Trafficking of GluR2-containing AMPA receptors COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network
Drugs			1-Ethyl-Pyrrolidine-2,5-Dione
Diseases
GWAS			Alcohol use disorder (total score) ( 30336701) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Cortical surface area ( 32963231) Cortical surface area (global PC1) ( 32198502) Cortical volume ( 32963231) General factor of neuroticism ( 30867560) Handedness (Left-handed vs. non-left-handed) ( 30980028) Handedness (Right-handed vs. non-right-handed) ( 30980028) Hemoglobin levels ( 32327693) Hypertrophic cardiomyopathy ( 33495596) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 30054594) Macular thickness ( 30535121) Male-pattern baldness ( 28196072) Parkinson's disease ( 21812969 19915575) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Reaction time ( 29844566) Refractive error ( 32231278) Sense of smell ( 26632684) Thyroid stimulating hormone levels ( 30367059)
Interacting Genes		9 interacting genes: ACKR5 APP EBI3 GABARAPL2 NAPA NSF SNAP25 STX5 USO1	31 interacting genes: ARRB1 ASPSCR1 CD28 CEP126 DRD2 EIF3E ERG28 ESR1 FILNC1 FUNDC2 GABARAP GABARAPL2 GABBR1 GABBR2 GOSR1 GRIA2 GRIA3 LUC7L2 MEOX2 NAPA NAPG PLK2 PTPN9 RAMP3 RNF10 RPLP1 STX1A STX4 STX8 USO1 VAPA
Entrez ID		9527	4905
HPRD ID		04936	03380
Ensembl ID		ENSG00000108587	ENSG00000073969
Uniprot IDs		E9PCW1 O95249	A0A384MTI6 P46459
PDB IDs			6KZQ
Enriched GO Terms of Interacting Partners?		SNARE Binding Membrane Fusion Golgi Vesicle Transport Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport SNARE Complex Disassembly Vesicle Docking Membrane Organization Organelle Localization By Membrane Tethering Membrane Docking Vesicle Fusion Organelle Membrane Fusion Regulation Of Protein Catabolic Process Establishment Of Localization In Cell Syntaxin-1 Binding Organelle Fusion Synaptic Vesicle Priming Protein-containing Complex Disassembly Secretory Granule Localization Protein Transport Intracellular Protein Transport Positive Regulation Of Protein Catabolic Process Intracellular Transport SNAP Receptor Activity Golgi Stack Dendritic Shaft Establishment Of Protein Localization Golgi Apparatus SNARE Complex Syntaxin Binding Protein-containing Complex Organization Amyloid-beta Complex Growth Cone Lamellipodium Chemical Synaptic Transmission Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Localization Vesicle Organization ER To Golgi Transport Vesicle Membrane Golgi Vesicle Docking Trans-synaptic Signaling Synaptic Signaling Positive Regulation Of Type II Interferon Production Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Intracellular Protein Localization Interleukin-27 Receptor Binding Associative Learning	Membrane Fusion SNARE Complex Intracellular Protein Localization SNARE Binding Protein Transport Organelle Localization By Membrane Tethering Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport Membrane Docking SNAP Receptor Activity Vesicle Fusion Establishment Of Protein Localization Chemical Synaptic Transmission Organelle Membrane Fusion Trans-synaptic Signaling Synaptic Signaling G Protein-coupled GABA Receptor Activity G Protein-coupled GABA Receptor Complex G Protein-coupled Receptor Heterodimeric Complex Organelle Fusion Intracellular Protein Transport Vesicle Docking Positive Regulation Of Synaptic Transmission Dendritic Spine Regulation Of Protein Localization To Cell Periphery GABA Receptor Complex Golgi Vesicle Transport Soluble NSF Attachment Protein Activity Regulation Of Protein Localization To Membrane Membrane Organization Negative Regulation Of Dopamine Secretion Vesicle Organization Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Modulation Of Chemical Synaptic Transmission Intracellular Transport Regulation Of Postsynaptic Membrane Potential Neuron-glial Cell Signaling Regulation Of Catecholamine Secretion Negative Regulation Of Synaptic Transmission Establishment Of Localization In Cell GABA Receptor Activity AMPA Glutamate Receptor Activity Postsynaptic Membrane Regulation Of Protein Localization To Plasma Membrane ATP-dependent Protein Binding Chloride Channel Inhibitor Activity Synaptic Transmission, Glutamatergic Cell-cell Signaling Syntaxin Binding Endomembrane System
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