SPTLC2 and SPTLC1

Number of citations of the paper that reports this interaction (PubMedID 40437099)
172

Data Source:
BioGRID (cross-linking study)
HPRD (in vivo, in vitro)

		SPTLC2	SPTLC1
Description		serine palmitoyltransferase long chain base subunit 2	serine palmitoyltransferase long chain base subunit 1
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Serine Palmitoyltransferase Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Serine Palmitoyltransferase Complex
	Molecular Function	Serine C-palmitoyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Pyridoxal Phosphate Binding	Serine C-palmitoyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Pyridoxal Phosphate Binding
	Biological Process	Lipid Metabolic Process Sphingolipid Metabolic Process Sphingomyelin Biosynthetic Process Sphingolipid Biosynthetic Process Sphinganine Biosynthetic Process Sphingosine Biosynthetic Process Ceramide Biosynthetic Process Adipose Tissue Development Positive Regulation Of Lipophagy	Lipid Metabolic Process Sphingolipid Metabolic Process Sphingomyelin Biosynthetic Process Sphingolipid Biosynthetic Process Amide Biosynthetic Process Sphinganine Biosynthetic Process Sphingosine Biosynthetic Process Ceramide Biosynthetic Process Positive Regulation Of Lipophagy Regulation Of Fat Cell Apoptotic Process
Pathways		Sphingolipid de novo biosynthesis	Sphingolipid de novo biosynthesis
Drugs		Pyridoxal phosphate Serine	Pyridoxal phosphate Serine
Diseases
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Red cell distribution width ( 32888494)	Bipolar disorder and schizophrenia ( 22688191) Left inferior lateral ventricle volume (Cerebrospinal fluid biomarker status interaction) ( 25140149) Serum immune biomarker levels ( 32066700)
Interacting Genes		2 interacting genes: NOTCH3 SPTLC1	5 interacting genes: ABCA1 GABBR2 GTF2IRD1 SPTLC2 TRIM38
Entrez ID		9517	10558
HPRD ID		05755	05754
Ensembl ID		ENSG00000100596	ENSG00000090054
Uniprot IDs		O15270	O15269 Q6NUL7
PDB IDs		6M4N 6M4O 7CQI 7CQK 7K0I 7K0J 7K0K 7K0L 7K0M 7K0N 7K0O 7K0P 7K0Q 7YIU 7YIY 7YJ1 7YJ2	6M4N 6M4O 7CQI 7CQK 7K0I 7K0J 7K0K 7K0L 7K0M 7K0N 7K0O 7K0P 7K0Q 7YIU 7YIY 7YJ1 7YJ2
Enriched GO Terms of Interacting Partners?		Sphinganine Biosynthetic Process Regulation Of Fat Cell Apoptotic Process Sphinganine Metabolic Process Glomerular Capillary Formation Neuroblast Differentiation Serine Palmitoyltransferase Complex Positive Regulation Of Lipophagy Serine C-palmitoyltransferase Activity Sphingosine Biosynthetic Process Sphingomyelin Biosynthetic Process Sphingoid Biosynthetic Process Sphingosine Metabolic Process Sphingomyelin Metabolic Process Diol Metabolic Process Endoplasmic Reticulum Membrane Neuron Fate Commitment Pyridoxal Phosphate Binding Positive Regulation Of MiRNA Transcription Ceramide Biosynthetic Process Artery Morphogenesis Positive Regulation Of MiRNA Metabolic Process Forebrain Development Negative Regulation Of Neuron Differentiation Regulation Of MiRNA Transcription Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of MiRNA Metabolic Process Ceramide Metabolic Process Positive Regulation Of Macroautophagy Sphingolipid Biosynthetic Process Blood Vessel Morphogenesis	Response To Vitamin B3 Positive Regulation Of High-density Lipoprotein Particle Assembly Apolipoprotein A-I Receptor Activity Sphingolipid Floppase Activity Sphinganine Biosynthetic Process Sphinganine Metabolic Process G Protein-coupled GABA Receptor Complex G Protein-coupled GABA Receptor Activity G Protein-coupled Receptor Heterodimeric Complex Transition Between Slow And Fast Fiber Apolipoprotein A-I-mediated Signaling Pathway Floppase Activity Regulation Of High-density Lipoprotein Particle Assembly Sphingolipid Translocation Apolipoprotein A-I Binding Phosphatidylserine Floppase Activity Positive Regulation Of Lipophagy Serine C-palmitoyltransferase Activity GABA Receptor Complex Neuron-glial Cell Signaling Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Lipoprotein Biosynthetic Process Phosphatidylcholine Floppase Activity GABA Receptor Activity Serine Palmitoyltransferase Complex High-density Lipoprotein Particle Assembly Alcohol Metabolic Process High-density Lipoprotein Particle Binding ATPase-coupled Intramembrane Lipid Transporter Activity Negative Regulation Of Cholesterol Storage Sphingomyelin Biosynthetic Process Negative Regulation Of Adenylate Cyclase Activity Regulation Of Skeletal Muscle Adaptation Phospholipid Efflux Regulation Of Cdc42 Protein Signal Transduction Negative Regulation Of Macrophage Derived Foam Cell Differentiation Sphingosine Biosynthetic Process Sphingoid Biosynthetic Process Phospholipid Homeostasis Phospholipid Transporter Activity Apolipoprotein Binding Reverse Cholesterol Transport Cellular Response To Cholesterol Positive Regulation Of Viral Entry Into Host Cell Negative Regulation Of Defense Response To Virus Sphingosine Metabolic Process Cellular Response To Sterol Intracellular Vesicle Sphingomyelin Metabolic Process Intracellular Cholesterol Transport
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