FXR2 and HOMER3

Number of citations of the paper that reports this interaction (PubMedID 21653829)
54

Data Source:
BioGRID (two hybrid)

		FXR2	HOMER3
Description		FMR1 autosomal homolog 2	homer scaffold protein 3
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule Membrane Cytoplasmic Ribonucleoprotein Granule Neuron Projection Synapse Presynapse Postsynapse	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Dendrite Basal Part Of Cell Synapse Glutamatergic Synapse
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity Translation Regulator Activity Protein Heterodimerization Activity	Protein Binding Protein Domain Specific Binding G Protein-coupled Glutamate Receptor Binding Identical Protein Binding
	Biological Process	Regulation Of Translation Dentate Gyrus Development Regulation Of MRNA Stability Positive Regulation Of Translation Positive Regulation Of Long-term Neuronal Synaptic Plasticity Animal Organ Development MRNA Transport MRNA Destabilization Regulation Of Translation At Presynapse, Modulating Synaptic Transmission	Protein Targeting G Protein-coupled Glutamate Receptor Signaling Pathway Negative Regulation Of Interleukin-2 Production Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Store-operated Calcium Entry
Pathways			Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Atrial fibrillation ( 30061737) Brain morphology (MOSTest) ( 32665545) IgM levels ( 23118916) Monocyte count ( 32888494) Refractive error ( 32231278) Sex hormone-binding globulin levels ( 22675492)
Interacting Genes		191 interacting genes: AKAP9 AMOTL2 AP1M1 AP2M1 ARHGEF7 ARL6IP1 ATN1 AXIN1 AXIN2 BAZ2B BCKDK BCL11A BLK BRCA1 BYSL C10orf62 C1orf35 CALCOCO2 CAMK2B CAMK2G CAPRIN1 CBS CCAR2 CCDC33 CCDC85B CCDC92 CCN3 CCR4 CDKL3 CEP44 CEP55 CHRD COIL COMT CSNK2B CWF19L2 CYFIP1 CYFIP2 DCTN2 DCTPP1 DDX17 DEAF1 DGKD DMRTB1 DNM2 DPPA2 DYNLT1 ECH1 ECHS1 EDC4 EGFL7 EIF4G1 EVL EWSR1 FAM90A1 FBP1 FMR1 FTH1 FXR1 GFAP GKAP1 GOLGA2 GPSM1 GPSM2 GRIP1 GTSE1 HIVEP1 HMBOX1 HNRNPC HNRNPM HNRNPR HOMER3 HSPB1 IGFN1 IMPDH2 INPP5J KCNRG KCTD4 KHDRBS1 KIAA1217 KIF1A KIF2A KIF7 KRT18 KRT20 KXD1 L3MBTL1 L3MBTL3 LASP1 LCMT1 LCP2 LDOC1 MAGED1 MAPKBP1 MAPRE3 MBIP MCRS1 MEAF6 MFAP1 MIA3 MORF4L1 MPP1 MRPL43 MSANTD3 MVP MYH10 NASP NCK2 NDEL1 NDN NECAB2 NEXN NIF3L1 NKD2 NME1 NME3 NONO NT5C2 PAF1 PAICS PCBD1 PCM1 PDE9A PHC1P1 PHC2 PHLDB1 PICK1 PIM1 PKM PNMA1 POM121 PPP1R12C PRAM1 PRC1 PRPF6 PSME1 PSME3 PTS PYCR2 PYCR3 RABAC1 RAD54L2 RAI2 RALYL RBBP8 RBM14 RBM45 RBMX RBPMS RPIA RPS2 RTN3 RTN4 SCEL SCMH1 SF3B2 SFPQ SNAP23 SPRY1 SPRY2 SRPK2 SYT6 SYTL4 TBC1D22B TFCP2 THAP1 TLE5 TNFAIP1 TNIP2 TNNT1 TRAF2 TRIM23 TRIM29 TRIM3 TRIM37 TRIOBP TSC22D4 TUT4 USP39 VIM WDR59 WEE2-AS1 YES1 ZBTB22 ZBTB8A ZMAT2 ZMYND8 ZNF232 ZNF451 ZNRD2 ZSCAN1	91 interacting genes: ABI1 ABI2 ABI3 APP ARL13B C1orf116 C4orf17 CCDC120 CCDC141 CCDC187 CDC37 CDK18 CEBPA CEBPB CFTR CWF19L2 DRC4 DVL3 DYNLL1 DYNLL2 EAF1 EFHC1 EIF3D FAM161B FAM90A1 FAT1 FMR1 FXR1 FXR2 GDF15 GGN GRM5 HOMER1 HOXB5 INCA1 ITPR1 KANK2 KANK4 KDM1A KRTAP19-7 LHX2 LNX1 LRRC7 LSM14B MDM1 MEOX1 MFAP1 MIA3 MOS MSS51 NEBL NTAQ1 OTX2 PAX6 PAX7 PKN1 PLAAT5 POLI POM121 PPP1R18 PRCC PRR35 PSMA1 PSMA2 PSMC5 PSORS1C2 RBM14 RBM22 RUNX1T1 RYR1 SAXO1 SAXO4 SCNM1 SDCBP SHANK3 SLAIN1 SMR3B SNCA SNRPF SRPK2 TBC1D22B TOX2 TRPC1 TSC1 USP2 WIPF1 ZBTB4 ZNF19 ZNF35 ZNF414 ZNF655
Entrez ID		9513	9454
HPRD ID		05629	07270
Ensembl ID		ENSG00000129245	ENSG00000051128
Uniprot IDs		P51116	Q9NSC5
PDB IDs		3H8Z	2P8V 3CVF
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Protein Binding Cytoplasm Cytosol Cytoskeleton Negative Regulation Of RNA Metabolic Process Neuron Projection MRNA Metabolic Process MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing RNA Splicing, Via Transesterification Reactions Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Establishment Of Mitotic Spindle Orientation Paraspeckles Nucleoplasm Regulation Of RNA Metabolic Process Centrosome Regulation Of Neurotrophin TRK Receptor Signaling Pathway MRNA Binding Negative Regulation Of DNA-templated Transcription Establishment Of Mitotic Spindle Localization Negative Regulation Of RNA Biosynthetic Process Regulation Of Cellular Component Organization Negative Regulation Of Macromolecule Metabolic Process Establishment Of Spindle Orientation Microtubule-based Process Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Nucleobase-containing Compound Metabolic Process Nucleolus Regulation Of MRNA Metabolic Process Endoplasmic Reticulum Tubular Network Formation Regulation Of Dendritic Spine Development RNA Binding Signaling Adaptor Activity Negative Regulation Of Metabolic Process Establishment Of Spindle Localization Negative Regulation Of Centriole Replication Intracellular Membraneless Organelle Establishment Of Organelle Localization Protein Domain Specific Binding Spindle Localization Regulation Of DNA-templated Transcription Regulation Of Cell Projection Organization Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Dendritic Spine Development Endoplasmic Reticulum Tubular Network Membrane Organization System Development	Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Protein Binding Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Dendritic Spine Cytoplasm Postsynapse Actin-based Cell Projection Postsynaptic Density SCAR Complex C/EBP Complex HMG Box Domain Binding Signaling Adaptor Activity Neuron Projection Growth Cone Filopodium CHOP-C/EBP Complex Cytoplasmic Ribonucleoprotein Granule Filopodium Tip Growth Cone Regulation Of Synaptic Plasticity Translation Regulator Activity Protein Tetramerization Glutamate Receptor Signaling Pathway Negative Regulation Of Cytoskeleton Organization Positive Regulation Of Neurogenesis Cytoskeleton Cytoskeletal Anchor Activity Regulation Of Cytosolic Calcium Ion Concentration RNA Strand Annealing Activity Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Synapse Organization Telencephalon Regionalization Dorsal/ventral Pattern Formation Regulation Of Nervous System Process Regulation Of Cytoskeleton Organization Regulation Of Nervous System Development Intracellular Membraneless Organelle Scaffold Protein Binding Negative Regulation Of Centriole Replication Positive Regulation Of Nervous System Development Regulation Of Synaptic Transmission, Glutamatergic 14-3-3 Protein Binding RNA Splicing Regulation Of Neurogenesis MRNA Splicing, Via Spliceosome Proteasome Core Complex, Alpha-subunit Complex Neuron Spine Regulation Of Cell Projection Organization Developmental Maturation
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