RASAL2 and SYNJ1

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		RASAL2	SYNJ1
Description		RAS protein activator like 2	synaptojanin 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Cytoplasm Cytosol Microtubule Vesicle Membrane Membrane Membrane Coat Clathrin Coat Of Coated Pit Terminal Bouton Perinuclear Region Of Cytoplasm Synaptic Membrane Presynapse
	Molecular Function	GTPase Activator Activity Protein Binding	Nucleic Acid Binding RNA Binding Phosphatidylinositol-3-phosphate Phosphatase Activity Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity Phosphatidylinositol Phosphate 5-phosphatase Activity Phosphatidylinositol Phosphate 4-phosphatase Activity Phosphatidylinositol-4-phosphate Phosphatase Activity Phosphatidylinositol-3,5-bisphosphate 5-phosphatase Activity Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Inositol-1,4,5-trisphosphate 5-phosphatase Activity
	Biological Process	Response To Dietary Excess Signal Transduction Response To Glucose Gene Expression Multicellular Organism Growth Adipose Tissue Development Regulation Of Intracellular Signal Transduction Regulation Of Protein Activation Cascade	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Neurotransmitter Transport Endocytosis Learning Synaptic Vesicle Priming Synaptic Vesicle Uncoating Phosphatidylinositol-3-phosphate Biosynthetic Process Inositol Phosphate Metabolic Process Phosphatidylinositol Metabolic Process Phosphatidylinositol Dephosphorylation Synaptic Vesicle Endocytosis Synaptic Vesicle Transport Membrane Organization Positive Regulation Of Endosome Organization
Pathways		Regulation of RAS by GAPs RND3 GTPase cycle RND1 GTPase cycle	Synthesis of PIPs at the plasma membrane Synthesis of IP2, IP, and Ins in the cytosol Synthesis of IP3 and IP4 in the cytosol Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Bipolar disorder ( 28115744) Body mass index ( 19079260 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Immune response to smallpox vaccine (IL-6) ( 22542470) Obesity-related traits ( 23251661) Plateletcrit ( 32888494) Weight ( 19079260)	Platelet reactivity in response to clopidogrel treatment ( 32472697)
Interacting Genes		10 interacting genes: HMGB1 MCC MEOX2 MIA2 NFKBIB SYNJ1 TRAF1 UBC USHBP1 YWHAG	31 interacting genes: AMPH AP2A1 AP2M1 BIN1 CDK5 CLTA CLTC EPHB2 EPS15 FNBP4 FOXRED1 GRB2 ITSN1 LRRK2 PACSIN1 PACSIN2 PACSIN3 PAX6 PPP3CA RASAL2 SH3BP1 SH3D19 SH3GL1 SH3GL2 SH3GL3 SH3GLB1 SH3KBP1 SH3YL1 SORBS1 SORBS2 VPS26C
Entrez ID		9462	8867
HPRD ID		05845	09182
Ensembl ID		ENSG00000075391	ENSG00000159082
Uniprot IDs		A0A8Q3SIU1 A0A8Q3SJF6 A8K2P3 Q9UJF2	A0A0D9SGJ6 B9EGN3 C9JFZ1 J3KQV8 O43426 Q05CZ1
PDB IDs			1W80 2DNR 2VJ0 7A0V
Enriched GO Terms of Interacting Partners?		Regulation Of T Cell Mediated Immune Response To Tumor Cell Regulation Of Response To Tumor Cell	Endocytosis Import Into Cell Vesicle-mediated Transport Synaptic Vesicle Endocytosis Presynaptic Endocytosis Vesicle-mediated Transport In Synapse Regulation Of Endocytosis Glutamatergic Synapse Endosome Regulation Of Vesicle-mediated Transport Postsynaptic Endocytic Zone Clathrin-dependent Endocytosis Clathrin-coated Pit Lipid Binding Establishment Of Localization In Cell Regulation Of Cellular Component Organization Receptor-mediated Endocytosis Cytosol Endolysosome Membrane Cytoskeleton Organization Clathrin-coated Endocytic Vesicle Receptor Internalization Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Coat Of Coated Pit Plasma Membrane Postsynaptic Neurotransmitter Receptor Internalization Synapse Positive Regulation Of Endocytosis Cell Projection Morphogenesis Negative Regulation Of Transport Intracellular Protein Localization Cellular Localization AP-2 Adaptor Complex Regulation Of Transport Cytoplasmic Vesicle Membrane Organization Plasma Membrane Tubulation Regulation Of Protein Localization To Plasma Membrane Phospholipid Binding Intracellular Transport Intracellular Protein Transport Synaptic Vesicle Identical Protein Binding Clathrin Coat Assembly Cell Projection Negative Regulation Of Endocytosis Clathrin-coated Endocytic Vesicle Membrane Neuron Projection Morphogenesis Cytoskeletal Protein Binding Regulation Of Protein Localization To Cell Periphery
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