QKI and PTBP2

Number of citations of the paper that reports this interaction (PubMedID 22365833)
0

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		QKI	PTBP2
Description		QKI, KH domain containing RNA binding	polypyrimidine tract binding protein 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule Synapse	Nucleus Spliceosomal Complex Growth Cone Neuronal Cell Body
	Molecular Function	Nucleic Acid Binding DNA Binding Transcription Coactivator Activity RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding SH3 Domain Binding MiRNA Binding Internal N(7)-methylguanine-containing RNA Reader Activity	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding
	Biological Process	Vasculogenesis MRNA Processing Regulation Of Translation Spermatid Development Intracellular MRNA Localization Axon Ensheathment RNA Splicing Positive Regulation Of Gene Expression Regulation Of Epithelial To Mesenchymal Transition Microglia Differentiation Negative Regulation Of Angiogenesis Negative Regulation Of Translation Cell Differentiation Positive Regulation Of Myelination Negative Regulation Of Type I Interferon Production Stress Granule Assembly Vascular Associated Smooth Muscle Cell Differentiation Myelination Long-chain Fatty Acid Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Macrophage Differentiation Negative Regulation Of Macrophage Differentiation Positive Regulation Of DNA-templated Transcription Regulation Of MRNA Splicing, Via Spliceosome MRNA Stabilization Regulation Of Astrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation MRNA Transport Regulation Of Cell Development Negative Regulation Of Cold-induced Thermogenesis Spliceosome-depend Formation Of Circular RNA Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Myofibroblast Contraction Regulation Of Multicellular Organismal Development Negative Regulation Of MiRNA Catabolic Process	MRNA Splice Site Recognition MRNA Processing RNA Splicing Spinal Cord Development Cerebellum Development Negative Regulation Of RNA Splicing Regulation Of RNA Splicing Regulation Of Neural Precursor Cell Proliferation
Pathways		Signaling by BRAF and RAF1 fusions
Drugs
Diseases
GWAS		Cataracts ( 34127677) Diastolic blood pressure ( 27841878) Diisocyanate-induced asthma ( 25918132) Fasting insulin ( 34059833) Height ( 31562340) Hemoglobin ( 32888494) Incident myocardial infarction ( 26950853) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444) Platelet distribution width ( 32888494) Red blood cell count ( 29403010) Refractive error ( 32231278) Response to TNF antagonist treatment ( 18615156) Seasonality and depression ( 30217971) Triglyceride levels ( 32203549) Type 2 diabetes ( 30297969 30718926)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Anorexia nervosa ( 31308545) Autism spectrum disorder ( 30804558) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 20935630 28892062 28448500 25673413) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically inactive individuals ( 28448500) Body size at age 10 ( 32376654) Chronotype ( 30696823) Daytime nap ( 33568662) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) Headache ( 29397368) Hip circumference ( 25673412) Number of sexual partners ( 30643258) Reaction time ( 29844566) Regular attendance at a pub or social club ( 29970889) Schizophrenia ( 22688191 19571811) Smoking status (ever vs never smokers) ( 30643258) Trunk fat mass adjusted for trunk lean mass ( 30944420 32239398) Waist circumference ( 25673412)
Interacting Genes		90 interacting genes: ALG13 ANKHD1 APP ATXN1 BAG4 BCAS2 CALD1 CARM1 CCDC59 CCND3 CDKN2D CEBPA CPSF7 DAZ1 DAZ4 DEPP1 DMRTB1 EIF4ENIF1 FBXO7 FHL3 FUBP3 HCLS1 HLCS HNRNPH2 HNRNPK HNRNPLL IL7R KIF21B LSM3 LSM5 MBNL1 MBNL2 MIR141 MIR19B2 MIR200A MIR34B MIR34C MIR7-1 MRPL44 MSI2 NABP1 NEIL3 NIP7 NXF1 PCBP1 PCBP2 PCBP3 PCBP4 PCGF5 PIAS1 PRKAB2 PRMT1 PRPF39 PRPF6 PRRC2B PSMF1 PTBP1 PTBP2 RALY RBFOX1 RBFOX2 RBM11 RBM14 RBM23 RBM42 RBM7 RBPMS RNF138 RPL9 SECISBP2 SERF2 SLAIN1 SNRPA SNRPC TEX11 THAP1 TIAL1 TNRC6A TRNAU1AP TSG101 TXNL4A U2AF2 UNKL USH1C UTP6 WDR77 YTHDF1 YTHDF3 ZC3H10 ZMAT5	28 interacting genes: CALCOCO2 EIF5A2 ELAVL1 GBP1 GOLGA2 HNRNPAB HNRNPC HNRNPD ISY1 KHDRBS1 KHDRBS3 KHSRP LINC00624 MAGOH MATR3 OGT PCBP2 PCBP3 PKN2 PRDX4 PUF60 QKI RBM10 RBM4 RBPMS2 SNRPA SRPK2 TOM1
Entrez ID		9444	58155
HPRD ID		06691	12233
Ensembl ID		ENSG00000112531	ENSG00000117569
Uniprot IDs		Q8WY44 Q96PU8	A0A6Q8PFE6 A0A7I2RVZ4 B4DSS8 B4DSU5 Q9UKA9
PDB IDs		4JVH	2CQ1 2MJU 4CQ1
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding Regulation Of RNA Splicing MRNA Binding RNA Splicing Regulation Of MRNA Metabolic Process MRNA Processing MRNA Metabolic Process Nucleic Acid Metabolic Process RNA Processing RNA Metabolic Process Nucleus Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Nucleobase-containing Compound Metabolic Process Spliceosomal Complex Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Ribonucleoprotein Complex Negative Regulation Of MRNA Metabolic Process Post-transcriptional Regulation Of Gene Expression MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process RNA Splicing, Via Transesterification Reactions Nucleoplasm Negative Regulation Of RNA Splicing Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process MRNA 3'-UTR Binding Cytoplasmic Stress Granule Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process U4/U6 X U5 Tri-snRNP Complex Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process MiRNA-mediated Post-transcriptional Gene Silencing Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Regulatory NcRNA-mediated Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Commitment Complex Regulation Of Translation Viral RNA Genome Replication Regulation Of MRNA Stability Negative Regulation Of RNA Metabolic Process	Regulation Of MRNA Metabolic Process Nucleic Acid Binding RNA Binding MRNA Metabolic Process MRNA Binding Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing MRNA Processing Regulation Of RNA Splicing RNA Metabolic Process Post-transcriptional Regulation Of Gene Expression RNA Splicing RNA Processing RNA Splicing, Via Transesterification Reactions Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Catabolic Process MiRNA Binding Negative Regulation Of RNA Catabolic Process Nucleic Acid Metabolic Process Negative Regulation Of MRNA Metabolic Process MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process MRNA Stabilization Negative Regulation Of Catabolic Process Ribonucleoprotein Complex Nucleus Positive Regulation Of Translation RNA Stabilization Regulation Of Translation Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability Positive Regulation Of Gene Expression Regulation Of Gene Expression Circadian Regulation Of Translation Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process 3'-UTR-mediated MRNA Stabilization Regulation Of Nucleobase-containing Compound Metabolic Process MRNA 3'-UTR AU-rich Region Binding Cytoplasmic Stress Granule Regulation Of Primary Metabolic Process Nucleoplasm Positive Regulation Of Protein-containing Complex Disassembly Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Metabolic Process Non-canonical Inflammasome Complex Assembly Negative Regulation Of Gene Expression
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