TJP2 and CGN

Number of citations of the paper that reports this interaction (PubMedID 10613913)
68

Data Source:
HPRD (in vitro, in vivo)

		TJP2	CGN
Description		tight junction protein 2	cingulin
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane Adherens Junction Bicellular Tight Junction Membrane Cell-cell Contact Zone Tight Junction Anchoring Junction	Plasma Membrane Bicellular Tight Junction Myosin Complex Cell Junction Anchoring Junction
	Molecular Function	GMP Kinase Activity Protein Binding Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Cadherin Binding Cell Adhesion Molecule Binding Protein Tyrosine Kinase Binding	Actin Binding Protein Binding Microtubule Binding Cadherin Binding
	Biological Process	Homotypic Cell-cell Adhesion Maintenance Of Blood-brain Barrier Cell-cell Junction Organization GMP Metabolic Process GDP Metabolic Process Intestinal Absorption Establishment Of Endothelial Intestinal Barrier Regulation Of Membrane Permeability Cell-cell Adhesion Protein Localization To Cell-cell Junction Positive Regulation Of Blood-brain Barrier Permeability	Microtubule Cytoskeleton Organization
Pathways		Signaling by Hippo Apoptotic cleavage of cell adhesion proteins RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Drugs
Diseases
GWAS		Macular thickness ( 30535121) Myopia ( 27182965) Night sleep phenotypes ( 27126917) Refractive error ( 23396134 32231278) Renal sinus fat ( 22044751) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Weight gain in amisulpride-treated first-episode psychosis ( 32126890)	Body mass index ( 26426971)
Interacting Genes		16 interacting genes: CDK6 CGN CLDN1 CLDN2 CLK1 CTNNA1 EPB41 HGS HSPB1 SAFB SCRIB SH3KBP1 TJP1 YWHAB YWHAG YWHAZ	10 interacting genes: ARHGEF2 CDC42 F11R LNX1 PPP1R13B RNF10 TJP1 TJP2 TP53BP2 YWHAG
Entrez ID		9414	57530
HPRD ID		06369	10827
Ensembl ID		ENSG00000119139	ENSG00000143375
Uniprot IDs		A0A3B3IU51 B7Z2R3 B7Z954 Q9UDY2	Q9P2M7
PDB IDs		2OSG 3E17
Enriched GO Terms of Interacting Partners?		Cell Junction Anchoring Junction Cadherin Binding Cell-cell Junction Focal Adhesion Protein Kinase C Inhibitor Activity Cell-cell Adhesion Cell-cell Junction Assembly Tight Junction Bicellular Tight Junction Protein Localization To Adherens Junction Protein Sequestering Activity Negative Regulation Of Protein Localization To Nucleus Phosphoserine Residue Binding Cell-cell Junction Organization Structural Molecule Activity Protein Targeting Protein Domain Specific Binding Regulation Of Multicellular Organismal Process Basolateral Plasma Membrane Regulation Of Intestinal Absorption Protein Localization To Cell Junction Intracellular Protein Localization Cell Adhesion Cell Junction Assembly Establishment Of Endothelial Intestinal Barrier Regulation Of Developmental Process Regulation Of Translational Initiation Protein Localization To Cell-cell Junction Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Regulation Of Bicellular Tight Junction Assembly Epithelial Cell Development Regulation Of Protein Localization To Nucleus Maintenance Of Blood-brain Barrier Establishment Of Endothelial Barrier Phosphoprotein Binding Identical Protein Binding Anatomical Structure Homeostasis Tissue Homeostasis Adherens Junction Establishment Of Protein Localization Endothelial Cell Development Cell Junction Organization Bicellular Tight Junction Assembly Cyclin D2-CDK6 Complex Negative Regulation Of Protein Kinase C Signaling Protein Kinase C Binding Negative Regulation Of Translational Initiation Xenobiotic Transport Across Blood-nerve Barrier Cellular Response To Glucose Starvation	Establishment Of Endothelial Intestinal Barrier Protein Localization To Cell-cell Junction Maintenance Of Blood-brain Barrier Tight Junction Establishment Of Endothelial Barrier Bicellular Tight Junction Endothelial Cell Development Positive Regulation Of Blood-brain Barrier Permeability Protein Localization To Bicellular Tight Junction Regulation Of Blood-brain Barrier Permeability Protein Localization To Cell Junction Regulation Of Stress Fiber Assembly Positive Regulation Of Vascular Permeability Regulation Of Supramolecular Fiber Organization Epithelial Cell Development Anchoring Junction Regulation Of Bicellular Tight Junction Assembly Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Cell Junction Organization Cell-cell Junction Organization Positive Regulation Of Cell Adhesion Intestinal Absorption Anatomical Structure Homeostasis Tissue Homeostasis Negative Regulation Of Stress Fiber Assembly Regulation Of Cytoskeleton Organization Intracellular Protein Localization Cell Junction Negative Regulation Of Actin Filament Bundle Assembly Regulation Of Vascular Permeability Regulation Of Actin Filament Organization Adherens Junction Organization Negative Regulation Of Cellular Component Organization Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Protein-containing Complex Cadherin Binding Regulation Of Membrane Permeability Circulatory System Process Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion P53 Binding Regulation Of Actin Cytoskeleton Organization Digestive System Process Ubiquitin Protein Ligase Activity Actin Cytoskeleton Organization PDZ Domain Binding Regulation Of Actin Filament-based Process Apical Part Of Cell GBD Domain Binding
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