ENTREP1 and WWP1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		ENTREP1	WWP1
Description		endosomal transmembrane epsin interactor 1	WW domain containing E3 ubiquitin protein ligase 1
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Plasma Membrane Membrane Early Endosome Membrane Late Endosome Membrane Recycling Endosome Membrane	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Extracellular Exosome Anchoring Junction
	Molecular Function	Protein Binding Ubiquitin Ligase Activator Activity	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Negative Adaptation Of Signaling Pathway Receptor Internalization CXCL12-activated CXCR4 Signaling Pathway	Ubiquitin-dependent Protein Catabolic Process Signal Transduction Central Nervous System Development Protein Ubiquitination Monoatomic Ion Transmembrane Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Symbiont Entry Into Host Cell
Pathways			Downregulation of ERBB4 signaling Stimuli-sensing channels Regulation of RUNX2 expression and activity Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Estimated glomerular filtration rate ( 31152163)
Interacting Genes		11 interacting genes: BAG3 CALCOCO2 NEDD4 OPTN SFN STAM2 TAX1BP1 UBQLN1 UBXN1 WWP1 WWP2	59 interacting genes: ASH2L ATN1 CBL CDKN1B CLCN5 CPSF6 DAG1 DAZAP2 DIDO1 ENTREP1 EWSR1 FBXL18 HSPB1 IKBKG IL2RG IL6R KLF2 LAPTM5 LATS1 LNX1 LZTR1 MACROH2A2 MIR19A MIR19B1 NFE2 NOTCH1 PCBD1 PHF20L1 PRKAA2 PRRG4 PTEN PYGM RASA1 RNF11 RTN4 RUNX1 SCNN1A SFTPC SHANK3 SLC2A1 SMAD3 SMAD5 STAT6 TFAP2A TGIF1 TP53 TP53BP2 TRAF4 TXNIP UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3 WASL WBP1 WBP2 YWHAQ ZNF638
Entrez ID		9413	11059
HPRD ID		16255	03811
Ensembl ID		ENSG00000135063	ENSG00000123124
Uniprot IDs		Q15884 Q8WU02	Q9H0M0
PDB IDs			1ND7 2OP7 5HPS 5HPT 6J1X 6J1Y 8EI4 9EQK
Enriched GO Terms of Interacting Partners?		Catabolic Process Autophagy Regulation Of Macroautophagy Autophagosome Polyubiquitin Modification-dependent Protein Binding Regulation Of Autophagy Macroautophagy Cytosol Phosphoserine Residue Binding Negative Regulation Of Potassium Ion Export Across Plasma Membrane Positive Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Cation Transmembrane Transport Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process Potassium Channel Inhibitor Activity Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Monoatomic Ion Transmembrane Transport Protein Catabolic Process Regulation Of Potassium Ion Export Across Plasma Membrane Positive Regulation Of Macroautophagy Negative Regulation Of Monoatomic Ion Transport Ubiquitin Binding Proteolysis Involved In Protein Catabolic Process Ubiquitin Ligase Complex Negative Regulation Of Transmembrane Transport Regulation Of Nucleocytoplasmic Transport Cytoplasm Cellular Response To Unfolded Protein Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Intracellular Transport Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of ERAD Pathway Negative Regulation Of Transporter Activity Cellular Response To Topologically Incorrect Protein Negative Regulation Of Potassium Ion Transport Positive Regulation Of Autophagy Proteasomal Protein Catabolic Process Aggresome Regulation Of Protein Export From Nucleus Intracellular Protein Transport Protein-macromolecule Adaptor Activity Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein Transport Intracellular Protein Localization Protein Ubiquitination Ubiquitin-protein Transferase Activity Protein Localization To Organelle Proteolysis Regulation Of Monoatomic Cation Transmembrane Transport	WW Domain Binding Ubiquitin Protein Ligase Binding Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Programmed Cell Death Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Nucleoplasm Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Regulation Of Organ Growth Regulation Of Extracellular Matrix Assembly Regulation Of DNA-templated Transcription Response To Hormone Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Developmental Process Regulation Of Signal Transduction Cell Fate Commitment Positive Regulation Of Biosynthetic Process Regulation Of Extracellular Matrix Organization Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Multicellular Organismal Development Modification-dependent Protein Catabolic Process Identical Protein Binding Negative Regulation Of DNA-templated Transcription Ubiquitin Conjugating Enzyme Activity Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Apoptotic Process Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Developmental Process Apoptotic Process Ubiquitin Ligase Activator Activity Enzyme Binding Regulation Of Protein Metabolic Process
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