HTRA3 and JAKMIP1

		HTRA3	JAKMIP1
Description		HtrA serine peptidase 3	janus kinase and microtubule interacting protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Cytoplasm Cytoskeleton Microtubule Membrane Ribonucleoprotein Complex
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Identical Protein Binding	RNA Binding Protein Binding Microtubule Binding Kinase Binding GABA Receptor Binding
	Biological Process	Proteolysis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway	Protein Transport Cognition
Pathways
Drugs
Diseases
GWAS		Response to cognitive-behavioural therapy in major depressive disorder ( 31123309)	Coronary artery disease in type 1 diabetes ( 29695241) Response to angiotensin II receptor blocker therapy ( 22566498) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Tau burden ( 33426524)
Interacting Genes		2 interacting genes: JAKMIP1 XIAP	29 interacting genes: ARK2N BLK BOD1L1 CBX8 CHRM3 CLNK DDX6 DSCR9 ENKD1 FXR1 GABBR1 HTRA3 IL16 JAK1 MCRS1 MKX MRFAP1L1 MRPL11 NKX2-1 PSMB1 SCNM1 TADA2B TRMT44 TSGA10IP TYK2 USP2 YES1 YWHAG ZNHIT2
Entrez ID		94031	152789
HPRD ID		08821	11292
Ensembl ID		ENSG00000170801	ENSG00000152969
Uniprot IDs		P83110	B3KWB6 Q96N16
PDB IDs		2P3W 4RI0
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Linear Polyubiquitination Regulation Of Apoptosis Involved In Tissue Homeostasis Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Protein Linear Polyubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Protein Polyubiquitination Copper Ion Homeostasis Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process GABA Receptor Binding Execution Phase Of Apoptosis P38MAPK Cascade Protein Serine/threonine Kinase Binding Regulation Of Protein Polyubiquitination Cysteine-type Endopeptidase Inhibitor Activity Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway	Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Growth Hormone Receptor Binding Interleukin-10-mediated Signaling Pathway Type III Interferon-mediated Signaling Pathway Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Type II Interferon-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT
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