NMT2 and TMED9

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		NMT2	TMED9
Description		N-myristoyltransferase 2	transmembrane p24 trafficking protein 9
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Host Cell	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Synaptic Vesicle Membrane Transport Vesicle COPII-coated ER To Golgi Transport Vesicle Trans-Golgi Network Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Extracellular Exosome
	Molecular Function	Glycylpeptide N-tetradecanoyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Peptidyl-lysine N6-myristoyltransferase Activity	Protein Binding Syntaxin Binding
	Biological Process	N-terminal Peptidyl-glycine N-myristoylation Regulation Of Opsin-mediated Signaling Pathway Protein Localization To Membrane Intracellular Transport Of Virus	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Organization Positive Regulation Of Organelle Organization Protein Transport Protein Exit From Endoplasmic Reticulum Early Endosome To Golgi Transport COPI Coating Of Golgi Vesicle
Pathways		Membrane binding and targetting of GAG proteins eNOS activation Inactivation, recovery and regulation of the phototransduction cascade	COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs		Myristoyl-Coa S-(2-oxo)pentadecylcoa 1-(CYCLOHEXYLAMINO)-3-(6-METHYL-3,4-DIHYDRO-1H-CARBAZOL-9(2H)-YL)PROPAN-2-OL (Z)-3-BENZYL-5-(2-HYDROXY-3-NITROBENZYLIDENE)-2-THIOXOTHIAZOLIDIN-4-ONE
Diseases
GWAS		Clozapine-induced agranulocytosis ( 25187353) Mild to moderate chronic kidney disease ( 31178898) Osteoporosis-related phenotypes (MTAG) ( 32107650) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)	Obesity-related traits ( 23251661) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		14 interacting genes: ANXA4 ANXA7 APP BCL2 BTF3 CASP3 CSNK2B PPP1CC PRKCZ RBM11 SMN1 TK1 TMED9 TP53	15 interacting genes: AQP9 CDC42 CKMT2 COPZ1 DDX54 ITM2A MAT2B MTF2 NMT2 PLPPR2 SEC22A SEC23B THAP8 TMEM60 YTHDF1
Entrez ID		9397	54732
HPRD ID		11948	09975
Ensembl ID		ENSG00000152465	ENSG00000184840
Uniprot IDs		B3KT39 O60551 Q5VUC6	Q9BVK6
PDB IDs		4C2X 6PAU	9CJK 9CJL
Enriched GO Terms of Interacting Partners?		Response To Light Stimulus B Cell Lineage Commitment Leukocyte Apoptotic Process Glial Cell Apoptotic Process Nucleus Positive Regulation Of Neuron Apoptotic Process Response To Radiation Regulation Of Neuron Apoptotic Process Protein Tetramerization Identical Protein Binding Developmental Process Response To Metal Ion Negative Regulation Of Cell Population Proliferation Developmental Growth Molecular Function Activator Activity Positive Regulation Of Amyloid Precursor Protein Catabolic Process Protein Phosphatase 2A Binding Neuron Apoptotic Process T Cell Apoptotic Process B Cell Homeostasis Response To UV Release Of Cytochrome C From Mitochondria Response To Ionizing Radiation Protease Binding Response To Oxidative Stress Hematopoietic Stem Cell Differentiation Response To X-ray Photoperiodism Entrainment Of Circadian Clock By Photoperiod Entrainment Of Circadian Clock Neuron Maturation T Cell Lineage Commitment Positive Regulation Of Excitatory Postsynaptic Potential Vesicle Membrane Lymphocyte Apoptotic Process T Cell Homeostasis Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway Cell Fate Commitment Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of T Cell Apoptotic Process Regulation Of Glial Cell Proliferation Regulation Of Apoptotic Process Response To Nicotine T Cell Differentiation In Thymus Regulation Of Programmed Cell Death Cytoplasm Cellular Developmental Process Calcium-dependent Phospholipid Binding
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