GRHPR and LSM1

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
HPRD (two hybrid)

		GRHPR	LSM1
Description		glyoxylate and hydroxypyruvate reductase	LSM1 homolog, mRNA degradation associated
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Peroxisomal Matrix Cytosol Extracellular Exosome Catalytic Complex	P-body Nucleus Cytoplasm Cytosol Lsm1-7-Pat1 Complex Ribonucleoprotein Complex
	Molecular Function	Protein Binding Hydroxypyruvate Reductase (NADH) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Hydroxypyruvate Reductase [NAD(P)H] Activity Glyoxylate Reductase (NADPH) Activity Carboxylic Acid Binding Protein Homodimerization Activity NADP Binding NAD Binding NADPH Binding Hydroxypyruvate Reductase (NADPH) Activity	RNA Binding MRNA Binding Protein Binding
	Biological Process	Carboxylic Acid Metabolic Process Dicarboxylic Acid Metabolic Process Glyoxylate Metabolic Process	Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA RNA Splicing, Via Transesterification Reactions Nuclear-transcribed MRNA Catabolic Process MRNA Processing RNA Splicing Stem Cell Population Maintenance Neuron Differentiation Negative Regulation Of Neuron Differentiation Histone MRNA Catabolic Process
Pathways		Glyoxylate metabolism and glycine degradation	mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease
Drugs
Diseases		Primary hyperoxaluria (HP)
GWAS		Bipolar disorder ( 31043756) C-reactive protein levels ( 33339817) Chronotype ( 30696823) Morning person ( 30696823) Severe bacterial meningitis ( 31092817)	Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 22037555 28991256 29483656)
Interacting Genes		7 interacting genes: CDC7 FOS GLS2 LCOR LIG4 LSM1 PTH2R	34 interacting genes: AGR2 AGR3 BEX5 CLIC1 DAPL1 EXOSC6 EXOSC8 GLUD1 GOLGA7 GRHPR GSTA4 HSP90AA1 LSM2 LSM3 LSM5 LSM6 LSM7 MCCD1 MPDU1 N4BP1 NARS1 NDUFAF3 NSD3 PSMB5 PSMB8 PTPRC RRP1B SMN1 TCL1B TFCP2 TMEM214 UPF2 UXT VPS11
Entrez ID		9380	27257
HPRD ID		05052	06281
Ensembl ID		ENSG00000137106	ENSG00000175324
Uniprot IDs		A0A384N605 Q9UBQ7	A0A0S2Z590 O15116
PDB IDs		2GCG 2H1S 2Q50 2WWR
Enriched GO Terms of Interacting Partners?		Response To Prolactin Conditioned Taste Aversion Medium-term Memory Cellular Response To Prolactin Establishment Of Integrated Proviral Latency DNA Ligase (ATP) Activity Stem Cell Population Maintenance DNA Ligase IV Complex Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination Maintenance Of Cell Number Establishment Of Viral Latency DNA Ligase Activity DN2 Thymocyte Differentiation Parathyroid Hormone Receptor Activity L-glutamine Catabolic Process Glutaminase Activity Cellular Response To Metal Ion Transcription Factor AP-1 Complex Cellular Response To Zinc Ion Starvation Nucleotide-excision Repair, DNA Gap Filling Glutamate Biosynthetic Process Lsm1-7-Pat1 Complex Response To Gravity DNA-dependent Protein Kinase-DNA Ligase 4 Complex Positive Regulation Of Nuclear Cell Cycle DNA Replication	Lsm2-8 Complex U6 SnRNP Lsm1-7-Pat1 Complex MRNA Catabolic Process MRNA Metabolic Process U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome RNA Catabolic Process RNA Splicing, Via Transesterification Reactions Nucleobase-containing Compound Catabolic Process RNA Splicing RNA Metabolic Process RNA Binding MRNA Processing Macromolecule Catabolic Process Spliceosomal Complex RNA Processing Negative Regulation Of Gene Expression MRNA Splicing, Via Spliceosome Nuclear-transcribed MRNA Catabolic Process Nucleic Acid Metabolic Process U4 SnRNA 3'-end Processing Threonine-type Endopeptidase Activity Dystroglycan Binding Nucleolar Exosome (RNase Complex) Catabolic Process Proteasome Core Complex, Beta-subunit Complex Nuclear MRNA Surveillance U6 SnRNA Binding Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity RRNA Catabolic Process Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Macromolecule Metabolic Process Precatalytic Spliceosome Catalytic Step 2 Spliceosome Proteasome Core Complex Nucleobase-containing Compound Metabolic Process RRNA Processing Ribonucleoprotein Complex SnRNA 3'-end Processing P-body RRNA Metabolic Process Positive Regulation Of Isotype Switching CTP Binding DATP Binding Protein Folding Chaperone Complex Plasma Membrane Raft Distribution Hydroxypyruvate Reductase [NAD(P)H] Activity
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