CADPS2 and UBE2E3

Number of citations of the paper that reports this interaction (PubMedID 19690564)
61

Data Source:
BioGRID (two hybrid)

		CADPS2	UBE2E3
Description		calcium dependent secretion activator 2	ubiquitin conjugating enzyme E2 E3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Cytoskeleton Cilium Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Ciliary Basal Body Presynaptic Membrane Cell Projection Synapse Postsynaptic Membrane Parallel Fiber To Purkinje Cell Synapse Presynapse Glutamatergic Synapse	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Lipid Binding Metal Ion Binding	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Exocytosis Cellular Response To Starvation Protein Transport Synaptic Vesicle Exocytosis Synaptic Vesicle Priming Positive Regulation Of Exocytosis Hematopoietic Stem Cell Homeostasis Dense Core Granule Exocytosis	Protein Monoubiquitination Negative Regulation Of Gene Expression Protein Ubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination
Pathways			Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Adult body size ( 32376654) Attention deficit hyperactivity disorder ( 30478444 32279069) Brain structure ( 20171287) General risk tolerance (MTAG) ( 30643258) Menarche (age at onset) ( 25231870) Number of sexual partners ( 30643258) Serum sulfate level ( 27412988) Smoking status (ever vs never smokers) ( 30643258) Waist circumference ( 28552196)	Ankylosing spondylitis ( 23749187) Basophil count ( 32888494) Body mass index ( 25673413) Celiac disease ( 22057235 20190752) Celiac disease and Rheumatoid arthritis ( 26546613) Heel bone mineral density ( 30598549) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lymphocyte count ( 29403010) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Number of sexual partners ( 30643258) Obesity ( 21552555) QT interval ( 29213071) Red blood cell count ( 27863252 32888494) Risk-taking tendency (4-domain principal component model) ( 30643258) Serum alkaline phosphatase levels ( 33547301) Sweet taste preference ( 32572145) White blood cell count ( 27863252)
Interacting Genes		18 interacting genes: BDNF DMD DRD2 MEGF10 SRPK2 TMEM132D TSPOAP1 TTC3 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2U UBE2W WDR4	98 interacting genes: ACVR1 ARID3A ARIH2 ARK2C ARRDC3 ASXL2 ATXN1 BARD1 BRCA1 CADPS2 CBL CHFR CHUK CNOT4 CUEDC1 CUL1 CUL3 CUL4A DAZAP2 DTX3 DTX3L DZIP3 HERC4 HMGB1 HTT IPO11 IRAK1 ITCH KLHL42 LAG3 MARCHF5 MDM2 MID1 MID2 MKRN3 MUL1 NEDD4L NFKBIA PGPEP1 PICK1 PJA1 PRKN RANGAP1 RBX1 RC3H2 RCBTB1 RFWD3 RING1 RMND5B RNF11 RNF111 RNF114 RNF115 RNF126 RNF13 RNF130 RNF14 RNF150 RNF166 RNF167 RNF181 RNF185 RNF2 RNF31 RNF4 RNF43 RNF5 RNF8 SAE1 SIAH1 SPOP STUB1 TGFBR1 TRIM2 TRIM27 TRIM32 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 TRIM54 TRIM55 TRIM62 TRIM63 TTC3 UBA1 UBA6 UBC UBOX5 UFM1 WBP2 WWP2 ZNF746 ZNF804A ZNRF1 ZNRF2 ZNRF4
Entrez ID		93664	10477
HPRD ID		12996	05000
Ensembl ID		ENSG00000081803	ENSG00000170035
Uniprot IDs		B7ZM57 Q86UW7 X5D2D9 X5D7B2 X5D8X0 X5DNG0	Q969T4
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Post-translational Protein Modification Protein Monoubiquitination Proteolysis Involved In Protein Catabolic Process Protein K11-linked Ubiquitination Protein Modification Process Transferase Activity ATP Binding Macromolecule Catabolic Process Proteolysis Nucleotide Binding Catabolic Process Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process TORC1 Signaling Negative Regulation Of TORC1 Signaling Protein K63-linked Ubiquitination TOR Signaling Proteasomal Protein Catabolic Process Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Positive Regulation Of Protein Polyubiquitination Protein K6-linked Ubiquitination Protein Catabolic Process Regulation Of Protein Polyubiquitination Ubiquitin Protein Ligase Activity Regulation Of TOR Signaling Macromolecule Metabolic Process DNA Damage Response DNA Repair Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production TRNA Methyltransferase Activator Activity TRNA (m7G46) Methyltransferase Complex Lateral Plasma Membrane Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Sodium Ion Transport Cellular Response To Nutrient Levels Protein Autoubiquitination Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission	Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Protein Polyubiquitination Protein Modification Process Ubiquitin-protein Transferase Activity Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Transferase Activity Proteolysis Involved In Protein Catabolic Process Protein Metabolic Process Macromolecule Catabolic Process Zinc Ion Binding Proteolysis Protein Autoubiquitination Macromolecule Metabolic Process Catabolic Process Protein K48-linked Ubiquitination Metal Ion Binding Cytoplasm Protein K63-linked Ubiquitination Protein Catabolic Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Protein Monoubiquitination Response To Stress Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Signal Transduction Ubiquitin Ligase Complex Positive Regulation Of Catabolic Process Protein Destabilization Protein K6-linked Ubiquitination Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Innate Immune Response Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Autophagy Defense Response To Symbiont Positive Regulation Of Metabolic Process Cellular Response To Stress Defense Response To Other Organism
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