SLIT2 and SEL1L3

		SLIT2	SEL1L3
Description		slit guidance ligand 2	SEL1L family member 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cell Surface Membrane Extracellular Exosome	Membrane
	Molecular Function	GTPase Inhibitor Activity Calcium Ion Binding Protein Binding Heparin Binding Identical Protein Binding Protein Homodimerization Activity Laminin-1 Binding Proteoglycan Binding Roundabout Binding
	Biological Process	Ureteric Bud Development Kidney Development Negative Regulation Of Protein Phosphorylation Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Leukocyte Chemotaxis Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Chemotaxis Nervous System Development Axon Guidance Motor Neuron Axon Guidance Negative Regulation Of Lamellipodium Assembly Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Neuron Projection Development Negative Regulation Of Smooth Muscle Cell Migration Olfactory Bulb Development Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Corticospinal Neuron Axon Guidance Through Spinal Cord Telencephalon Cell Migration Cell Differentiation Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Negative Regulation Of Actin Filament Polymerization Retinal Ganglion Cell Axon Guidance Regulation Of Cellular Component Size Cellular Response To Hormone Stimulus Roundabout Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Vascular Permeability Branching Morphogenesis Of An Epithelial Tube Axon Extension Involved In Axon Guidance Regulation Of Neurogenesis Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Negative Chemotaxis Induction Of Negative Chemotaxis Negative Regulation Of Small GTPase Mediated Signal Transduction Response To Cortisol Ventricular Septum Morphogenesis Epithelial Tube Morphogenesis Apoptotic Process Involved In Luteolysis Negative Regulation Of Chemokine-mediated Signaling Pathway Cellular Response To Heparin Negative Regulation Of Smooth Muscle Cell Chemotaxis Negative Regulation Of Mononuclear Cell Migration Circulatory System Development Negative Regulation Of Neutrophil Chemotaxis Negative Regulation Of Monocyte Chemotaxis Negative Regulation Of Retinal Ganglion Cell Axon Guidance Negative Regulation Of Cellular Response To Growth Factor Stimulus
Pathways		Netrin-1 signaling Signaling by ROBO receptors Signaling by ROBO receptors Activation of RAC1 Regulation of commissural axon pathfinding by SLIT and ROBO Inactivation of CDC42 and RAC1 Role of ABL in ROBO-SLIT signaling Role of ABL in ROBO-SLIT signaling SLIT2:ROBO1 increases RHOA activity Regulation of expression of SLITs and ROBOs Regulation of expression of SLITs and ROBOs Formation of the ureteric bud
Drugs
Diseases
GWAS		Adiponectin levels x Mediterranean diet adherence interaction ( 33562295) Adult body size ( 32376654) Body mass index ( 31453325) Body mass index variance ( 31453325) Early spontaneous preterm birth ( 31194736) Echocardiographic traits ( 17903301) Gestational age at birth (child effect) ( 31194736) HDL cholesterol levels in HIV infection ( 33109212) Pars orbitalis volume ( 31530798) QRS duration ( 27659466) Response to long-chain n-3 polyunsaturated fatty acid supplementation (change in triglyceride levels) ( 24847101) Serum metabolite concentrations in chronic kidney disease ( 29545352)	Systolic blood pressure ( 28234671)
Interacting Genes		12 interacting genes: CSDE1 GPC1 HOXA1 OGT PAX8 PDE4B ROBO1 ROBO2 SEL1L3 UBC USP7 ZCCHC4	3 interacting genes: RBPJ SLIT2 TUBB3
Entrez ID		9353	23231
HPRD ID		04776	11105
Ensembl ID		ENSG00000145147	ENSG00000091490
Uniprot IDs		O94813	Q68CR1
PDB IDs		2V70 2V9S 2V9T 2WFH
Enriched GO Terms of Interacting Partners?		Artery Development Negative Regulation Of Negative Chemotaxis Axon Midline Choice Point Recognition Regulation Of Negative Chemotaxis Axon Choice Point Recognition Heart Induction Regulation Of Heart Morphogenesis Axon Guidance Receptor Activity Regulation Of Animal Organ Morphogenesis Endocardial Cushion Formation Pulmonary Valve Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Blood Vessel Development Organ Induction Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Translation Outflow Tract Septum Morphogenesis Regulation Of Animal Organ Formation Developmental Induction Aorta Development Aortic Valve Morphogenesis Metanephros Development Ventricular Septum Morphogenesis Positive Regulation Of Notch Signaling Pathway Tube Development Neuron Recognition Mesonephric Epithelium Development Mesonephric Tubule Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Chemotaxis Positive Regulation Of Macromolecule Biosynthetic Process Semicircular Canal Formation Positive Regulation Of Metabolic Process Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Heart Valve Morphogenesis Regulation Of Thyroid-stimulating Hormone Secretion Regulation Of Gluconeogenesis Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Inner Ear Development Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process TORC1 Signaling Positive Regulation Of Gene Expression Positive Regulation Of Developmental Process Abducens Nerve Formation Optokinetic Behavior Negative Regulation Of Relaxation Of Cardiac Muscle	Ventricular Septum Morphogenesis Epithelial Tube Morphogenesis Cardiac Septum Morphogenesis Positive Regulation Of Ephrin Receptor Signaling Pathway Arterial Endothelial Cell Fate Commitment Induction Of Negative Chemotaxis Corticospinal Neuron Axon Guidance Through Spinal Cord MAML1-RBP-Jkappa- ICN1 Complex Endocardium Morphogenesis Blood Vessel Endothelial Cell Fate Specification Blood Vessel Lumenization Auditory Receptor Cell Fate Commitment Regulation Of Cell Adhesion Involved In Heart Morphogenesis Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Apoptotic Process Involved In Luteolysis Neuron Projection Guidance Cellular Response To Heparin Negative Regulation Of Retinal Ganglion Cell Axon Guidance Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Axon Guidance Netrin Receptor Binding Tube Morphogenesis Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Club Cell Differentiation Epidermal Cell Fate Specification Aortic Valve Development Pulmonary Valve Development Hair Follicle Maturation Endocardium Development Endothelial Cell Fate Specification Semi-lunar Valve Development Response To Heparin Regulation Of Negative Chemotaxis Negative Regulation Of Lamellipodium Assembly Negative Regulation Of Neutrophil Migration Regulation Of Retinal Ganglion Cell Axon Guidance Roundabout Binding Negative Regulation Of Neutrophil Chemotaxis Roundabout Signaling Pathway Negative Regulation Of Smooth Muscle Cell Chemotaxis Dorsal Root Ganglion Development Morphogenesis Of An Epithelium Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Transcription Of Notch Receptor Target Response To Cortisol Laminin-1 Binding Negative Regulation Of Monocyte Chemotaxis Neuron Differentiation Sebaceous Gland Development Dorsal Aorta Morphogenesis
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