CD163 and MYH9

Number of citations of the paper that reports this interaction (PubMedID 15479433)
0

Data Source:
HPRD (in vivo)

		CD163	MYH9
Description		CD163 molecule	myosin heavy chain 9
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Plasma Membrane External Side Of Plasma Membrane Membrane Endocytic Vesicle Membrane	Stress Fiber Ruffle Immunological Synapse Uropod Nucleus Cytoplasm Golgi Apparatus Spindle Actomyosin Contractile Ring Cytosol Cytoskeleton Plasma Membrane Brush Border Adherens Junction Focal Adhesion Cell Cortex COP9 Signalosome Cytoplasmic Side Of Plasma Membrane Cell Surface Actin Cytoskeleton Membrane Myosin Complex Myosin II Complex Nuclear Body Cortical Cytoskeleton Cell Leading Edge Cytoplasmic Vesicle Neuromuscular Junction Cleavage Furrow Myosin Filament Protein-containing Complex Actomyosin Cortical Granule Extracellular Exosome Myosin II Filament Supramolecular Fiber
	Molecular Function	Scavenger Receptor Activity Protein Binding Scaffold Protein Binding	Microfilament Motor Activity Nucleotide Binding Virus Receptor Activity RNA Binding Cytoskeletal Motor Activity Actin Binding Integrin Binding Protein Binding Calmodulin Binding ATP Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Protein-membrane Adaptor Activity ADP Binding Cadherin Binding Actin Filament Binding
	Biological Process	Acute-phase Response Inflammatory Response Vesicle-mediated Transport	Meiotic Spindle Organization Cell Morphogenesis Angiogenesis In Utero Embryonic Development Establishment Of T Cell Polarity Plasma Membrane Repair Membrane Protein Ectodomain Proteolysis Phagocytosis, Engulfment Cytoskeleton Organization Cell Adhesion Integrin-mediated Signaling Pathway Myoblast Fusion Regulation Of Cell Shape Protein Transport Actin Cytoskeleton Organization Actin Filament-based Movement Platelet Formation Monocyte Differentiation Actomyosin Structure Organization Lysosome Localization Cytokinetic Process Uropod Organization Regulation Of Actin Filament-based Process Endodermal Cell Differentiation Blood Vessel Endothelial Cell Migration Regulated Exocytosis Symbiont Entry Into Host Cell Cell Motility Leukocyte Migration Establishment Of Meiotic Spindle Localization Cytoplasmic Actin-based Contraction Involved In Cell Motility Cortical Granule Exocytosis Platelet Aggregation Cell-cell Adhesion Negative Regulation Of Actin Filament Severing Positive Regulation Of Protein Processing In Phagocytic Vesicle Regulation Of Plasma Membrane Repair
Pathways		Scavenging of heme from plasma CD163 mediating an anti-inflammatory response	Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of actin dynamics for phagocytic cup formation EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea CD163 mediating an anti-inflammatory response FCGR3A-mediated phagocytosis Signaling by ALK fusions and activated point mutants
Drugs		Tetrachlorodecaoxide	Artenimol
Diseases			MYH9-related kidney diseases, including: Epstein syndrome; Fechtner syndrome Macrothrombocytopenia; May-Hegglin anomaly; Sebastian syndrome; Fechtner syndrome; Epstein syndrome Deafness, autosomal dominant
GWAS		Creatine kinase levels ( 29403010) HDL cholesterol levels ( 28334899) Hematological and biochemical traits ( 20139978) High density lipoprotein cholesterol levels ( 29083408)	Diabetic kidney disease ( 26305897) End-stage renal disease (non-diabetic) ( 20532800) Glomerulosclerosis ( 20668430) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference ( 30108283) Language performance in older adults (adjusted for episodic memory) ( 28577822) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Optic nerve measurement (rim area) ( 20395239) Platelet count ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		7 interacting genes: CSNK2B ERC1 FCGR1A HOXA1 HP MYH9 PRKCA	31 interacting genes: ANXA1 ASCC2 ATG9B CASP4 CBL CD163 CSNK2A1 CXCR4 DUX4 FXR1 GRIN1 MEN1 MTDH MYBPC3 MYH10 MYL9 MYOM1 MYOM2 NUDCD2 OVGP1 PPP2CA PTPN6 RAC1 RNF10 S100A4 SNCA TTN TUFM UBE2I WEE2-AS1 YWHAZ
Entrez ID		9332	4627
HPRD ID		05708	01177
Ensembl ID		ENSG00000177575	ENSG00000100345
Uniprot IDs		C9JHR8 Q86VB7	P35579
PDB IDs		8XMK 8XMP 8XMQ 8XMW 9FHB 9FMU 9FNO	2LNK 3ZWH 4CFQ 4CFR 4ETO
Enriched GO Terms of Interacting Partners?		Phosphorylation Protein Kinase CK2 Complex Protein Phosphorylation Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Phagocytosis, Engulfment Membrane Invagination High-affinity IgG Receptor Activity Acute Inflammatory Response Positive Regulation Of Type III Hypersensitivity Semicircular Canal Formation Abducens Nerve Formation Optokinetic Behavior Negative Regulation Of Hydrogen Peroxide Catabolic Process Uropod Organization Myosin II Filament Cortical Granule Exocytosis Negative Regulation Of Actin Filament Severing Positive Regulation Of Protein Processing In Phagocytic Vesicle Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Angiotensin-activated Signaling Pathway Histone H3T6 Kinase Activity Alphav-beta3 Integrin-PKCalpha Complex I-kappaB Phosphorylation Anatomical Structure Morphogenesis Positive Regulation Of Type IIa Hypersensitivity Integrin Binding Actomyosin Contractile Ring Protein Kinase C Signaling Membrane Organization Release From Viral Latency Hemoglobin Binding Response To Reactive Oxygen Species Cortical Granule Cytoplasmic Actin-based Contraction Involved In Cell Motility Regulation Of Angiotensin-activated Signaling Pathway Protein Metabolic Process Positive Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Viral Life Cycle IgG Receptor Activity Negative Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Endothelial Cell Migration Adiponectin-activated Signaling Pathway Positive Regulation Of Hypersensitivity Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Antibody-dependent Cellular Cytotoxicity Anatomical Structure Formation Involved In Morphogenesis	Structural Constituent Of Muscle Myosin Filament Actomyosin Structure Organization M Band Actin Cytoskeleton Organization Actin Filament-based Process Sarcomere Organization Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Skeletal Muscle Organ Development Cytoplasm Striated Muscle Myosin Thick Filament Positive Regulation Of Signal Transduction Myofibril Assembly Extraocular Skeletal Muscle Development Cytosol Organelle Organization Myosin Heavy Chain Binding Calcium Ion Binding Positive Regulation Of Transport Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Cellular Component Assembly Membraneless Organelle Assembly Positive Regulation Of Protein Secretion Supramolecular Fiber Intracellular Signal Transduction Positive Regulation Of Secretion By Cell Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Kinase A Signaling Regulation Of Microtubule Polymerization Positive Regulation Of Secretion Cytoskeleton Organization Cell Cortex Regulation Of Transport Cardiac Myofibril Assembly Inflammatory Response Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Secretion By Cell Regulation Of Intracellular Signal Transduction Regulation Of Synaptic Plasticity Glutamatergic Synapse Actin Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Vesicle Fusion Regulation Of Secretion Regulation Of Microtubule Polymerization Or Depolymerization
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