CD14 and ARFGAP3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CD14	ARFGAP3
Description		CD14 molecule	ARF GTPase activating protein 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Cell Surface Endosome Membrane Membrane Secretory Granule Membrane Membrane Raft Lipopolysaccharide Receptor Complex Extracellular Exosome Side Of Membrane	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Membrane
	Molecular Function	Lipopolysaccharide Binding Opsonin Receptor Activity Lipopolysaccharide Immune Receptor Activity Protein Binding Peptidoglycan Immune Receptor Activity Lipoteichoic Acid Binding Molecular Carrier Activity	GTPase Activator Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Cytokine Production Response To Molecule Of Bacterial Origin Immune System Process Cell Surface Pattern Recognition Receptor Signaling Pathway Receptor-mediated Endocytosis Phagocytosis Apoptotic Process Inflammatory Response Cell Surface Receptor Signaling Pathway Response To Bacterium Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Innate Immune Response Positive Regulation Of Endocytosis Cellular Response To Molecule Of Bacterial Origin Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Cellular Response To Diacyl Bacterial Lipopeptide Cellular Response To Triacyl Bacterial Lipopeptide	Intracellular Protein Transport Protein Secretion Protein Transport Vesicle-mediated Transport COPI Coating Of Golgi Vesicle
Pathways		ER-Phagosome pathway Caspase activation via Death Receptors in the presence of ligand Toll Like Receptor 4 (TLR4) Cascade Transfer of LPS from LBP carrier to CD14 MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88-independent TLR4 cascade Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor TLR6:TLR2 Cascade TRIF-mediated programmed cell death MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Neutrophil degranulation Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Respiratory syncytial virus (RSV) attachment and entry Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 RSV-host interactions	COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic CDC42 GTPase cycle RHOG GTPase cycle
Drugs		Atibuclimab
Diseases		Asthma
GWAS		Blood protein levels ( 30072576) Refractive error ( 32231278) Schizophrenia ( 29483656) Serum immune biomarker levels ( 32066700)	Resting metabolic rate ( 28476931)
Interacting Genes		15 interacting genes: ARFGAP3 CD55 GJB2 IRAK3 ITGB2 LBP LGALS3BP LTF POLR2J PPP3R2 REEP5 TLR2 TLR3 TLR4 TNFRSF1B	10 interacting genes: APP CD14 CFTR CXCL8 LIME1 RTN4IP1 SMAD2 SNCA SYPL1 ZDHHC17
Entrez ID		929	26286
HPRD ID		01151	06444
Ensembl ID		ENSG00000170458	ENSG00000242247
Uniprot IDs		P08571	Q9NP61
PDB IDs		4GLP	2CRW
Enriched GO Terms of Interacting Partners?		Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Immune Response Regulation Of Immune Response Lipopolysaccharide Binding Lipopolysaccharide-mediated Signaling Pathway Regulation Of Cytokine Production Involved In Immune Response Cellular Response To Lipoteichoic Acid Toll-like Receptor Signaling Pathway Regulation Of Cytokine Production Detection Of Molecule Of Bacterial Origin Positive Regulation Of Innate Immune Response Regulation Of Interleukin-6 Production Macrophage Activation Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Interleukin-8 Production Regulation Of Interleukin-12 Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Innate Immune Response-activating Signaling Pathway Defense Response Positive Regulation Of Chemokine Production Cell Surface Regulation Of Production Of Molecular Mediator Of Immune Response Positive Regulation Of Immune System Process Activation Of Innate Immune Response Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus Activation Of Immune Response Regulation Of Interleukin-8 Production Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Innate Immune Response Positive Regulation Of Interleukin-6 Production Regulation Of Immune System Process Regulation Of Chemokine Production Positive Regulation Of Defense Response Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Matrix Metallopeptidase Secretion Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Immune Effector Process Detection Of Biotic Stimulus Positive Regulation Of Cytokine Production Regulation Of Defense Response Negative Regulation Of Osteoclast Differentiation Regulation Of Toll-like Receptor 4 Signaling Pathway Inflammatory Response Myeloid Leukocyte Activation Defense Response To Bacterium Response To External Biotic Stimulus Regulation Of Macrophage Cytokine Production Positive Regulation Of Interferon-beta Production Regulation Of Canonical NF-kappaB Signal Transduction	Response To Interleukin-1 Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Calcium Ion Transmembrane Transport Regulation Of Presynapse Organization Regulation Of Monoatomic Ion Transport Regulation Of Long-term Neuronal Synaptic Plasticity Response To Growth Factor Positive Regulation Of Endocytosis Regulation Of Presynapse Assembly Regulation Of Monoatomic Ion Transmembrane Transport Endocytosis Myeloid Leukocyte Activation Regulation Of Neurotransmitter Uptake Regulation Of Cell Communication Cellular Response To Copper Ion Regulation Of Signaling Response To Lipid Golgi-associated Vesicle Membrane Amyloid Fibril Formation Microglial Cell Activation Receptor-mediated Endocytosis Cellular Response To Fibroblast Growth Factor Stimulus Cytoplasmic Vesicle Membrane Response To Copper Ion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Vesicle-mediated Transport Leukocyte Activation Involved In Inflammatory Response Regulation Of Calcium Ion Transport Response To Fibroblast Growth Factor Import Into Cell Tau Protein Binding Amyloid-beta Complex Regulation Of Neuronal Synaptic Plasticity Growth Cone Lamellipodium Regulation Of Synapse Organization Regulation Of Response To Calcium Ion Regulation Of Signal Transduction Macrophage Activation Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To Growth Factor Stimulus Cellular Response To CAMP Regulation Of Monoatomic Cation Transmembrane Transport Opsonin Receptor Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Response To Desipramine
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