SCGB3A1 and MARCO

Number of citations of the paper that reports this interaction (PubMedID 12847263)
0

Data Source:
HPRD (in vivo)

		SCGB3A1	MARCO
Description		secretoglobin family 3A member 1	macrophage receptor with collagenous structure
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome	Collagen Trimer Cytoplasm Plasma Membrane Membrane Endocytic Vesicle Membrane
	Molecular Function	Cytokine Activity Protein Binding	Amyloid-beta Binding G Protein-coupled Receptor Binding Transmembrane Signaling Receptor Activity Cargo Receptor Activity Pattern Recognition Receptor Activity
	Biological Process	Signal Transduction Negative Regulation Of Cell Growth Regulation Of Cell Population Proliferation Positive Regulation Of Myoblast Fusion	Immune System Process Endocytosis Receptor-mediated Endocytosis Phagocytosis, Engulfment Cell Surface Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Apoptotic Cell Clearance Innate Immune Response Positive Regulation Of ERK1 And ERK2 Cascade Amyloid-beta Clearance
Pathways			Scavenging by Class A Receptors Scavenging by Class A Receptors
Drugs			Titanium dioxide Silicon dioxide
Diseases
GWAS		Blood protein levels ( 30072576) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Lung function (FVC) ( 30061609) Medication use (adrenergics, inhalants) ( 31015401) Triglyceride levels ( 32203549)
Interacting Genes		10 interacting genes: AURKA BAG4 FBXW7 FGFR4 MARCO NOTCH3 RHBDD2 TGFB1 TSG101 XRCC3	5 interacting genes: NAT14 SAP130 SCGB3A1 SCGB3A2 SNCA
Entrez ID		92304	8685
HPRD ID		05932	05337
Ensembl ID		ENSG00000161055	ENSG00000019169
Uniprot IDs		Q96QR1	Q4ZG40 Q9UEW3
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Intracellular Signal Transduction Regulation Of ERK1 And ERK2 Cascade Regulation Of ERBB Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Proteolysis Involved In Protein Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Fibroblast Migration Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Extracellular Matrix Disassembly Positive Regulation Of MAPK Cascade Lipid Homeostasis Regulation Of Signaling Regulation Of Cell Cycle Phase Transition Proteasomal Protein Catabolic Process Liver Regeneration Positive Regulation Of Cell Communication Positive Regulation Of Signaling Macromolecule Catabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Regulation Of Establishment Of Protein Localization Positive Regulation Of ERBB Signaling Pathway Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Proteolysis Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Fibroblast Migration Protein Catabolic Process Regulation Of Organelle Organization Proteolysis Regulation Of Protein Targeting To Mitochondrion Regulation Of MAPK Cascade Positive Regulation Of Cell Cycle Process Positive Regulation Of MiRNA Transcription Regulation Of Cell Cycle Process Regulation Of Centrosome Cycle Animal Organ Regeneration Branch Elongation Involved In Mammary Gland Duct Branching Positive Regulation Of Microglia Differentiation Vasculature Development Cellular Response To Acetaldehyde Negative Regulation Of MRNA Modification Positive Regulation Of MiRNA Metabolic Process Regulation Of Extracellular Matrix Organization Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Cell Cycle	Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process Dopamine Uptake Involved In Synaptic Transmission Mitochondrial ATP Synthesis Coupled Electron Transport Cuprous Ion Binding Regulation Of Chaperone-mediated Autophagy Response To Iron(II) Ion Dopamine Biosynthetic Process Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Cellular Respiration Negative Regulation Of Oxidative Phosphorylation Regulation Of Acyl-CoA Biosynthetic Process Supramolecular Fiber Catecholamine Uptake Dopamine Uptake Positive Regulation Of Inositol Phosphate Biosynthetic Process Positive Regulation Of Neurotransmitter Secretion Regulation Of SNARE Complex Assembly Regulation Of Hydrogen Peroxide Metabolic Process Negative Regulation Of Microtubule Polymerization SNARE Complex Assembly Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway ATP Synthesis Coupled Electron Transport Platelet Alpha Granule Membrane Dynein Complex Binding Synaptic Vesicle Priming Extracellular Space Dopamine Transport Inclusion Body Positive Regulation Of Receptor Recycling Neurotransmitter Reuptake Catecholamine Biosynthetic Process Cellular Response To Epinephrine Stimulus Response To Magnesium Ion Behavioral Response To Cocaine Phospholipase Binding Regulation Of Neurotransmitter Uptake
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