LGI1 and SLC27A2

		LGI1	SLC27A2
Description		leucine rich glioma inactivated 1	solute carrier family 27 member 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Golgi Apparatus Dendrite Synaptic Cleft Axon Initial Segment Synapse Glutamatergic Synapse	Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Specific Granule Membrane Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Protein Binding Receptor Ligand Activity	Nucleotide Binding Long-chain Fatty Acid-CoA Ligase Activity Long-chain Fatty Acid Transmembrane Transporter Activity ATP Binding Fatty Acid Transmembrane Transporter Activity Ligase Activity Enzyme Binding Very Long-chain Fatty Acid-CoA Ligase Activity Arachidonate-CoA Ligase Activity Cholate-CoA Ligase Activity Phytanate-CoA Ligase Activity Pristanate-CoA Ligase Activity
	Biological Process	Signal Transduction Nervous System Development Axon Guidance Positive Regulation Of Cell Growth Neuron Projection Development Positive Regulation Of Synaptic Transmission Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane	Very Long-chain Fatty Acid Metabolic Process Fatty Acid Alpha-oxidation Long-chain Fatty Acid Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Bile Acid Biosynthetic Process Lipid Transport Bile Acid Metabolic Process Fatty Acid Transport Long-chain Fatty Acid Transport Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Very Long-chain Fatty Acid Catabolic Process Long-chain Fatty Acid Import Into Cell Fatty-acyl-CoA Biosynthetic Process Methyl-branched Fatty Acid Metabolic Process
Pathways		LGI-ADAM interactions	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Alpha-oxidation of phytanate Beta-oxidation of very long chain fatty acids Neutrophil degranulation Fatty acyl-CoA biosynthesis Peroxisomal protein import Peroxisomal protein import
Drugs
Diseases		Autosomal dominant temporal lobe epilepsy (ADTLE); Autosomal dominant partial epilepsy with auditory features (ADPEAF)
GWAS		Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid AB1-42 levels ( 29274321) Response to (pegylated) interferon in chronic hepatitis B ( 30715261) Response to perphenazine in schizophrenia ( 29503163)	Platelet count ( 32888494) Verbal declarative memory ( 25648963)
Interacting Genes		3 interacting genes: ADAM22 CLIC6 SLC27A2	17 interacting genes: ABCD1 AP4E1 ARPP19 ATOSA DTWD1 GABPB1 GEMIN5 ICOSLG LGI1 PDCD11 PDE6G PEX5 PML RAB5C SLC24A1 UBC YWHAQ
Entrez ID		9211	11001
HPRD ID		05216	11935
Ensembl ID		ENSG00000108231	ENSG00000140284
Uniprot IDs		A0A0S2Z4S7 A0A0S2Z4X3 A0A0S2Z5G1 A0A1B0GUD3 O95970	O14975
PDB IDs		5Y2Z 5Y30 5Y31 8HPY 8HQ1 8HQ2 8Y6B
Enriched GO Terms of Interacting Partners?		Pristanate-CoA Ligase Activity Phytanate-CoA Ligase Activity Cholate-CoA Ligase Activity D4 Dopamine Receptor Binding D3 Dopamine Receptor Binding D2 Dopamine Receptor Binding Methyl-branched Fatty Acid Metabolic Process Fatty Acid Transmembrane Transporter Activity Very Long-chain Fatty Acid Catabolic Process Fatty Acid Alpha-oxidation Very Long-chain Fatty Acid-CoA Ligase Activity Arachidonate-CoA Ligase Activity Long-chain Fatty Acid Import Into Cell Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Lipid Import Into Cell Long-chain Fatty Acid-CoA Ligase Activity Long-chain Fatty Acid Transmembrane Transporter Activity Bile Acid Biosynthetic Process Fatty-acyl-CoA Biosynthetic Process Bile Acid Metabolic Process Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Transport Chloride Channel Complex	Protein Targeting
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