ZBED1 and GGACT

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZBED1	GGACT
Description		zinc finger BED-type containing 1	gamma-glutamylamine cyclotransferase
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Centrosome PML Body Nuclear Membrane	Cytosol Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding Protein Dimerization Activity SUMO Ligase Activity Sequence-specific Double-stranded DNA Binding	Protein Binding Lyase Activity Gamma-glutamylaminecyclotransferase Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Sumoylation Host-mediated Suppression Of Viral Genome Replication Positive Regulation Of Transcription By RNA Polymerase II Protein Autosumoylation	Modified Amino Acid Catabolic Process
Pathways		SUMOylation of chromatin organization proteins
Drugs			Formic acid
Diseases
GWAS			Refractive error ( 32231278) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		61 interacting genes: AIRIM AMOTL2 ATRX CBX4 CCDC13 CDC37 CTNNAL1 DGCR6 EFHC1 FABP4 FAM124B FANCG FNDC11 GGACT GORASP2 GPN1 GPSM1 KDM1A KIFC3 KLHL40 LCN2 LNX1 LRRC20 MAD2L2 MAGEB2 MKKS MLH1 MPST MYO15B NCDN NIF3L1 NIP7 NTAQ1 NUDT18 PAX6 PIAS1 PIAS2 PICK1 POLE2 POLR1C PRKAA1 PRKAR1A PSAP RANBP9 RENBP RIN1 SORBS3 SPEF1 SSX2 SUMO1 SUMO2 TDP2 TRAPPC2B TRIML2 TTC23 TTR UBE2I UCHL5 USP2 ZHX1 ZNF451	3 interacting genes: LDB2 PLAAT5 ZBED1
Entrez ID		9189	87769
HPRD ID		02170	14263
Ensembl ID		ENSG00000214717	ENSG00000134864
Uniprot IDs		O96006	Q9BVM4
PDB IDs		2CT5	3JUB 3JUC 3JUD
Enriched GO Terms of Interacting Partners?		Protein Sumoylation PML Body SUMO Transferase Activity SUMO Ligase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Presynaptic Cytosol Postsynaptic Cytosol Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Transcription Corepressor Activity Negative Regulation Of Metabolic Process Post-translational Protein Modification Protein Binding DNA Repair Ubiquitin Protein Ligase Binding Organelle Organization Small Protein Activating Enzyme Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Stress Nuclear Body Regulation Of Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Protein Modification Process Nucleoplasm Enzyme Binding Error-prone Translesion Synthesis Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Cytoplasm RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleotide-activated Protein Kinase Complex Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Response To Radiation Response To Light Stimulus Regulation Of RNA Metabolic Process Microtubule Cytoskeleton Organization Nucleus DNA Metabolic Process	Transcription Coregulator Activity Protein Autosumoylation LIM Domain Binding N-acylphosphatidylethanolamine Metabolic Process N-acyltransferase Activity SUMO Ligase Activity Host-mediated Suppression Of Viral Genome Replication
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