CD3G and KTN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CD3G	KTN1
Description		CD3 gamma subunit of T-cell receptor complex	kinectin 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane External Side Of Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane Alpha-beta T Cell Receptor Complex Gamma-delta T Cell Receptor Complex	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Plasma Membrane Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Complex Adaptor Activity T Cell Receptor Binding Identical Protein Binding	RNA Binding Protein Binding Kinesin Binding Cadherin Binding
	Biological Process	Adaptive Immune Response Immune System Process Establishment Or Maintenance Of Cell Polarity Cell Surface Receptor Signaling Pathway Protein Transport T Cell Activation Positive Thymic T Cell Selection Gamma-delta T Cell Activation Alpha-beta T Cell Activation T Cell Receptor Signaling Pathway Protein-containing Complex Assembly Regulation Of Lymphocyte Apoptotic Process	Microtubule-based Movement Protein Transport
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis Co-inhibition by PD-1 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate KTN1 Post-translational protein phosphorylation RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOG GTPase cycle RND3 GTPase cycle RND2 GTPase cycle
Drugs		Muromonab Teclistamab Odronextamab
Diseases
GWAS			Brain morphology (MOSTest) ( 32665545) Early spontaneous preterm birth ( 31194736) Lean body mass ( 28552196) Neurofibrillary tangles ( 31497858) Plasma anti-thyroglobulin levels ( 29678681) Subcortical brain region volumes ( 25607358)
Interacting Genes		15 interacting genes: CATSPERH CD3D CD3E DRD2 EMP1 KTN1 LAT MAL PMP22 TMEM19 TMEM203 TMEM54 TRA TRB TRD	32 interacting genes: ABI1 BNIP3 CD3G CD68 CDC42 CLEC4C CLEC7A EEF1D FFAR2 FILNC1 IKBKE INPP5E KIF5B KIR2DL3 LHFPL5 M6PR MEOX2 PDCD1LG2 PLEKHA5 RAC1 RHOA RHOG RNF10 SGTA SIRPA SLC71A2 STOM SUSD3 SYNE4 SYNPR TMEM179B UBE2I
Entrez ID		917	3895
HPRD ID		07037	02661
Ensembl ID		ENSG00000160654	ENSG00000126777
Uniprot IDs		B0YIY5 P09693	Q86UP2
PDB IDs		1SY6 6JXR 7FJD 7FJE 7FJF 7PHR 7Q5U 8ES7 8ES8 8ES9 8JC0 8JCB 8TW4 8TW6 8WXE 8WY0 8WYI 8YC0 9BBC 9C3E 9CI8 9CIA 9CQ4
Enriched GO Terms of Interacting Partners?		Alpha-beta T Cell Receptor Complex T Cell Receptor Complex Detection Of Tumor Cell T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Adaptive Immune Response Membrane Raft Distribution Immune Response To Tumor Cell Membrane Raft Localization Membrane Bleb Assembly Positive Thymic T Cell Selection Positive T Cell Selection T Cell Receptor Signaling Pathway T Cell Mediated Cytotoxicity Thymic T Cell Selection Plasma Membrane Antigen Receptor-mediated Signaling Pathway T Cell Selection Membrane Raft Organization Detection Of Biotic Stimulus Signaling Receptor Complex Adaptor Activity T Cell Mediated Immunity Immunological Synapse Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production TCR Signalosome Leukocyte Mediated Cytotoxicity T Cell Activation Gamma-delta T Cell Receptor Complex Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Negative Regulation Of Dopamine Receptor Signaling Pathway Membrane Raft Polarization Immune Response Immune Response-activating Signaling Pathway Alpha-beta T Cell Activation T Cell Anergy Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Renal Sodium Excretion Negative Regulation Of Dopamine Secretion Protein Localization To Paranode Region Of Axon Myelination Axon Ensheathment Compact Myelin	Ficolin-1-rich Granule Membrane Establishment Or Maintenance Of Cell Polarity Secretory Granule Membrane Establishment Of Epithelial Cell Apical/basal Polarity Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Membrane Polarized Epithelial Cell Differentiation Establishment Of Epithelial Cell Polarity Wnt Signaling Pathway, Planar Cell Polarity Pathway Glutamatergic Synapse G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Immune System Process Membrane Invagination Actin Filament Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Stress Fiber Assembly Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Non-canonical Wnt Signaling Pathway Azurophil Granule Membrane Thioesterase Binding Regulation Of Interleukin-23 Production Regulation Of Synapse Organization Positive Regulation Of Actin Filament Bundle Assembly Immune Response Tertiary Granule Membrane Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Antifungal Innate Immune Response G Protein Activity Regulation Of Canonical NF-kappaB Signal Transduction Plasma Membrane Cellular Response To Type II Interferon Positive Regulation Of Immune System Process Regulation Of Immune System Process Response To External Biotic Stimulus Positive Regulation Of Protein Localization To Membrane Regulation Of Respiratory Burst Regulation Of Modification Of Synaptic Structure Establishment Of Cell Polarity GTP-dependent Protein Binding Regulation Of Stress Fiber Assembly Regulation Of Cell Maturation Postsynapse Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Type II Interferon Regulation Of Chemokine Production Rac Protein Signal Transduction
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