EXO1 and KPNA4

Number of citations of the paper that reports this interaction (PubMedID 22222486)
57

Data Source:
BioGRID (pull down)

		EXO1	KPNA4
Description		exonuclease 1	karyopherin subunit alpha 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Plasma Membrane Nuclear Body	Male Germ Cell Nucleus Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Nuclear Membrane NLS-dependent Protein Nuclear Import Complex
	Molecular Function	DNA Binding Chromatin Binding Catalytic Activity Nuclease Activity Endonuclease Activity DNA Endonuclease Activity RNA-DNA Hybrid Ribonuclease Activity Exonuclease Activity Protein Binding 5'-3' Exonuclease Activity Hydrolase Activity Hydrolase Activity, Acting On Ester Bonds 5'-flap Endonuclease Activity 5'-3' DNA Exonuclease Activity Single-stranded DNA 5'-3' DNA Exonuclease Activity Metal Ion Binding Flap Endonuclease Activity Double-stranded DNA 5'-3' DNA Exonuclease Activity	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity
	Biological Process	Immune System Process Humoral Immune Response Mediated By Circulating Immunoglobulin DNA Repair Mismatch Repair DNA Recombination DNA Damage Response Somatic Hypermutation Of Immunoglobulin Genes Isotype Switching Meiotic Cell Cycle T-circle Formation DNA Strand Resection Involved In Replication Fork Processing	Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Gene Expression Dopamine Secretion Protein Transport Positive Regulation Of Hippo Signaling Response To Hydrogen Peroxide
Pathways		Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2	ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways
Drugs
Diseases
GWAS		Basal cell carcinoma ( 31174203) Breast cancer ( 25751625 29059683) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Keratinocyte cancer (MTAG) ( 31174203) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Menopause (age at onset) ( 22267201 26414677)	Alanine aminotransferase levels ( 33547301) Alcohol use disorder (total score) ( 30336701) Aspartate aminotransferase levels ( 33547301) Attention deficit hyperactivity disorder ( 32279069) Bipolar disorder ( 31043756) Malaria ( 31844061) Myeloproliferative neoplasms ( 33057200) Pit-and-Fissure caries ( 24556642) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Smooth-surface caries ( 24556642) Total cholesterol levels ( 30275531)
Interacting Genes		20 interacting genes: ATM BLM DCAF1 H4C1 KPNA4 KPNB1 MLH1 MLH3 MSH2 MSH3 PCNA PMS2 SENP6 SFN UBE2I YWHAB YWHAE YWHAG YWHAH YWHAZ	49 interacting genes: ADNP AFF2 APP CDKN1B CFAP298 CSE1L CSNK2A1 CTDSPL2 CUL4B DMTF1 DYRK1A EXO1 FAM50B GTF2IRD1 HIF1A HJURP HNRNPC HSD3B7 KAT5 KDR MAT2B MEF2C MORC3 MRTFB MTA1 NCBP3 NCOR2 NFE2L2 NKX2-5 NRIP1 NTRK3 OGT PLAA PLEKHG4B RAC1 RANBP3 RECQL RNF38 RYBP SCAND3 SPRTN SQSTM1 TGM2 TPX2 WT1 ZFTRAF1 ZMIZ2 ZNF532 ZRANB3
Entrez ID		9156	3840
HPRD ID		06932	04275
Ensembl ID		ENSG00000174371	ENSG00000186432
Uniprot IDs		A8K5H6 Q9UQ84	O00629
PDB IDs		3QE9 3QEA 3QEB 5UZV 5V04 5V05 5V06 5V07 5V08 5V09 5V0A 5V0B 5V0C 5V0D 5V0E 7MXQ 7MXR 7MXS 7MXT 7MXU 7MXV 7MXW 7MXX	4UAE 5TBK 5XZX 6BVV 6BVZ 6BW9 6BWA 6BWB 6WX8 7JJL 7LF4 7LFC 7RFY 7RG5 8FUB 8FZM 8HKW
Enriched GO Terms of Interacting Partners?		Mismatch Repair Mismatched DNA Binding Somatic Cell DNA Recombination ATP-dependent DNA Damage Sensor Activity Phosphoserine Residue Binding DNA Recombination Protein Sequestering Activity Dinucleotide Insertion Or Deletion Binding Chromosome Organization Negative Regulation Of DNA Recombination Guanine/thymine Mispair Binding Enzyme Binding Regulation Of DNA Recombination Mismatch Repair Complex Cellular Response To Stress Positive Regulation Of Isotype Switching To IgA Isotypes DNA Metabolic Process DNA Repair Somatic Recombination Of Immunoglobulin Gene Segments Nucleus DNA Damage Response Single-stranded DNA Binding Protein Domain Specific Binding Somatic Diversification Of Immunoglobulins Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Isotype Switching To IgG Isotypes Male Germ Cell Nucleus Somatic Hypermutation Of Immunoglobulin Genes Negative Regulation Of DNA Metabolic Process Somatic Diversification Of Immune Receptors Via Somatic Mutation Regulation Of Isotype Switching To IgG Isotypes Regulation Of DNA Metabolic Process Intracellular Protein Localization Nucleoplasm Chiasma MutSbeta Complex Dinucleotide Repeat Insertion Binding Chromosome, Telomeric Region Positive Regulation Of Hippo Signaling Positive Regulation Of DNA Recombination Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Synaptonemal Complex Protein Kinase C Inhibitor Activity MutLalpha Complex Single Guanine Insertion Binding Response To X-ray Reciprocal Meiotic Recombination Positive Regulation Of Isotype Switching Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process	Nucleus Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression Rhythmic Process Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Modification Process Negative Regulation Of DNA-templated Transcription Regulation Of Programmed Cell Death Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Transcription Positive Regulation Of Developmental Process Chromatin Organization Regulation Of Developmental Growth Apoptotic Process Regulation Of MiRNA Metabolic Process Regulation Of Cellular Component Organization Regulation Of Growth Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Chromatin Regulation Of Synapse Assembly Aggrephagy Protein Targeting To Vacuole Involved In Autophagy Programmed Cell Death Cell Death Regulation Of Cell Junction Assembly DNA Binding DNA Repair Epithelial Tube Morphogenesis Regulation Of Synapse Organization Positive Regulation Of Catabolic Process
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