RNF185 and YIPF4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		RNF185	YIPF4
Description		ring finger protein 185	Yip1 domain family member 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum Quality Control Compartment	Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Plasma Membrane Endomembrane System Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Binding Ubiquitin-like Protein Conjugating Enzyme Binding Protein-containing Complex Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Immune System Process Ubiquitin-dependent Protein Catabolic Process Autophagy Protein Ubiquitination ERAD Pathway Protein K27-linked Ubiquitination Innate Immune Response Positive Regulation Of Innate Immune Response Defense Response To Virus Protein Autoubiquitination Transmembrane Transport Positive Regulation Of Type I Interferon-mediated Signaling Pathway CGAS/STING Signaling Pathway Positive Regulation Of ERAD Pathway Endoplasmic Reticulum Mannose Trimming	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle Fusion With Golgi Apparatus
Pathways		ABC-family proteins mediated transport Defective CFTR causes cystic fibrosis ER Quality Control Compartment (ERQC) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Fish- and plant-related diet ( 32066663) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Waist circumference ( 28552196) White blood cell count ( 32888494)	Chronotype ( 30696823) Male-pattern baldness ( 28196072) Refractive error ( 32231278)
Interacting Genes		30 interacting genes: APP CGAS CMTM5 CYB561A3 DVL2 FAM241B MALL MS4A13 MTNR1B MYADML2 NIPAL4 TMEM147 TMEM19 TMEM86A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2V1 UBE2W USP21 YIPF2 YIPF4 YIPF6	39 interacting genes: AQP6 ARL6IP1 BIK CD79A CNR2 CYB5R3 EBP ERGIC3 FAM209A FAM98A FATE1 FCER1G FKBP7 GPR152 GPR42 HSD17B13 IER3IP1 NAT8 REEP4 RNF185 RNF5 SCN3B SLC10A1 SLC18A1 SLC30A6 SLC30A8 SLC35A4 SLC35H1 SLC71A2 SLC7A1 SLC7A14 TIMMDC1 TLCD4 TMEM14B TSNARE1 TVP23B YIF1A YIPF3 ZDHHC15
Entrez ID		91445	84272
HPRD ID		08790	14410
Ensembl ID		ENSG00000138942	ENSG00000119820
Uniprot IDs		Q96GF1	Q9BSR8
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein K11-linked Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Monoubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Modification Process Proteolysis Involved In Protein Catabolic Process ATP Binding Protein K63-linked Ubiquitination Nucleotide Binding Transferase Activity ISG15 Transferase Activity Proteolysis ISG15-protein Conjugation Macromolecule Catabolic Process Golgi Trans Cisterna Golgi Medial Cisterna Protein Metabolic Process Positive Regulation Of Protein Polyubiquitination Protein Binding Protein K6-linked Ubiquitination Regulation Of Protein Polyubiquitination Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Frizzled Binding SUMO Conjugating Enzyme Activity 2',3'-cyclic GMP-AMP Synthase Activity	Membrane Endoplasmic Reticulum Transmembrane Transport Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Transmembrane Transporter Activity Zinc:proton Antiporter Activity Mitochondrial Membrane COPII-coated ER To Golgi Transport Vesicle Ubiquitin-like Protein Conjugating Enzyme Binding Pyrimidine Nucleotide-sugar Transmembrane Transport Zinc Ion Import Into Organelle Nucleotide-sugar Transmembrane Transport Serotonin Transport Endoplasmic Reticulum Organization Endoplasmic Reticulum Mannose Trimming Golgi Membrane Protein Alpha-1,2-demannosylation Monoatomic Cation Transmembrane Transporter Activity Insulin Metabolic Process Endoplasmic Reticulum-Golgi Intermediate Compartment Protein Deglycosylation Endoplasmic Reticulum Tubular Network Organization Protein Binding Endoplasmic Reticulum Tubular Network Zinc Ion Transmembrane Transporter Activity Endoplasmic Reticulum Quality Control Compartment Antiporter Activity Zinc Ion Transmembrane Transport
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