SMC3 and SMC1A

Number of citations of the paper that reports this interaction (PubMedID 11076961)
58

Data Source:
HPRD (in vivo)

		SMC3	SMC1A
Description		structural maintenance of chromosomes 3	structural maintenance of chromosomes 1A
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Lateral Element Nucleus Nucleoplasm Chromosome Cytosol Cohesin Complex Nuclear Matrix Mitotic Cohesin Complex Meiotic Cohesin Complex Nuclear Lumen Mitotic Spindle Pole	Chromosome, Centromeric Region Kinetochore Condensed Nuclear Chromosome Nucleus Nucleoplasm Chromosome Cytosol Cohesin Complex Nuclear Matrix Mitotic Cohesin Complex Meiotic Cohesin Complex Mitotic Spindle Pole
	Molecular Function	Nucleotide Binding Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Double-stranded DNA Binding Microtubule Motor Activity Protein Binding ATP Binding ATP Hydrolysis Activity Mediator Complex Binding Protein Heterodimerization Activity Beta-tubulin Binding Dynein Complex Binding	Nucleotide Binding DNA Binding Chromatin Binding RNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Mediator Complex Binding Protein Heterodimerization Activity
	Biological Process	Mitotic Cell Cycle Regulation Of DNA Replication DNA Repair DNA Damage Response Sister Chromatid Cohesion Mitotic Sister Chromatid Cohesion Stem Cell Population Maintenance Establishment Of Mitotic Sister Chromatid Cohesion Establishment Of Meiotic Sister Chromatid Cohesion Chromosome Organization Cell Division Meiotic Cell Cycle Mitotic Spindle Assembly	Mitotic Sister Chromatid Segregation DNA Repair DNA Damage Response Sister Chromatid Cohesion Mitotic Sister Chromatid Cohesion Response To Radiation Establishment Of Mitotic Sister Chromatid Cohesion Establishment Of Meiotic Sister Chromatid Cohesion Somatic Stem Cell Population Maintenance Chromosome Organization Cell Division Meiotic Cell Cycle Response To DNA Damage Checkpoint Signaling Mitotic Spindle Assembly
Pathways		Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression	Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression
Drugs
Diseases		Cornelia de Lange syndrome (CdLS)	Cornelia de Lange syndrome (CdLS)
GWAS		Acute respiratory distress syndrome in sepsis ( 31982041) Lumbar spine bone mineral density (integral) ( 27476799) Metabolite levels ( 23823483)	Bipolar disorder ( 31043756) Mean corpuscular volume ( 32888494)
Interacting Genes		20 interacting genes: APC CEBPA CEP63 CYP27B1 DISC1 ESCO2 ESR1 FEZ1 FEZ2 KIFAP3 MTNR1B MXD1 MXD3 MXD4 MXI1 RPGR SMC1A SMC1B SUMO2 TRAF3IP1	23 interacting genes: ALK AMOT ATM BLM BRCA1 CEBPA ESR1 FGF14 ITSN1 MCM6 MCM7 MDC1 MET MSH2 MSH6 NDC80 NUMA1 POLA1 RAD21 RFC1 RPGR SMC3 SUMO2
Entrez ID		9126	8243
HPRD ID		05829	02077
Ensembl ID		ENSG00000108055	ENSG00000072501
Uniprot IDs		Q9UQE7	A0A384MR33 G8JLG1 Q14683 Q68EN4
PDB IDs		6WG3 6WG4 6WG6 6WGE 7W1M 8P0A 8PQ5 8ROH 8ROI 8ROJ 8ROK 8ROL	6WG3 6WG4 6WG6 6WGE 7W1M 8P0A 8PQ5 8RO6 8RO7 8RO8 8RO9 8ROA 8ROB 8ROC 8ROD 8ROE 8ROF 8ROG
Enriched GO Terms of Interacting Partners?		Centrosome Ciliary Basal Body Cohesin Complex Meiotic Cohesin Complex Sister Chromatid Cohesion Condensed Nuclear Chromosome Protein Dimerization Activity Negative Regulation Of Metabolic Process Negative Regulation Of Autophagosome Assembly Chromatin Mitotic Sister Chromatid Cohesion Organelle Organization Microtubule-based Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Metabolic Process Positive Regulation Of Catabolic Process Cilium Organization Plasma Membrane Bounded Cell Projection Organization Nucleoplasm RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Ciliary Transition Zone Developmental Process Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Calcidiol 1-monooxygenase Activity Secalciferol 1-monooxygenase Activity Photoreceptor Connecting Cilium Transport Along Microtubule Cell Projection Organization Organelle Assembly Negative Regulation Of Macroautophagy Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Regulation Of Neuroblast Proliferation Kinesin Binding Positive Regulation Of Calcium-dependent Cell-cell Adhesion Ciliary Base Negative Regulation Of Macromolecule Metabolic Process Kinesin Complex Ciliary Tip Intraciliary Transport Regulation Of Autophagosome Assembly Cytoskeleton-dependent Intracellular Transport Regulation Of Microtubule-based Movement Positive Regulation Of Proteolysis DNA Binding Protein Localization To Chromatin	Chromosome DNA Repair DNA Metabolic Process DNA Damage Response Double-strand Break Repair DNA Recombination Regulation Of DNA Metabolic Process Negative Regulation Of Mitotic Cell Cycle Chromosome Organization Negative Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Cellular Response To Stress Nuclear Matrix Double-strand Break Repair Via Homologous Recombination Nucleic Acid Metabolic Process Recombinational Repair Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA Damage Checkpoint Signaling Single-stranded DNA Binding Nucleoplasm Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA Recombination Intracellular Signal Transduction Lateral Element Regulation Of DNA Recombination Regulation Of Cell Cycle Phase Transition DNA Replication Four-way Junction DNA Binding Signal Transduction In Response To DNA Damage Single Thymine Insertion Binding MutSalpha Complex Chromatin Binding Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Chromosome Separation Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Chromosome, Telomeric Region Regulation Of Metabolic Process DNA Binding Nucleotide Binding Regulation Of Cell Cycle ATP Binding Single Guanine Insertion Binding Establishment Of Meiotic Sister Chromatid Cohesion
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