IGFN1 and DDAH2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		IGFN1	DDAH2
Description		immunoglobulin like and fibronectin type III domain containing 1	DDAH family member 2, ADMA-independent
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Z Disc	Cytoplasm Mitochondrion Extracellular Exosome
	Molecular Function	Protein Binding	Protein Binding Dimethylargininase Activity Hydrolase Activity
	Biological Process		Citrulline Metabolic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Nitric Oxide Biosynthetic Process
Pathways
Drugs			Citrulline
Diseases
GWAS		Asthma ( 29273806) Height ( 28552196)	Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Ulcerative colitis ( 28067908)
Interacting Genes		40 interacting genes: ACTMAP BANP BLZF1 COG6 CRX DDAH2 FXR2 GOLGA2 HIVEP1 HOXA1 HOXD3 KCTD9 KIFC3 KRT39 KRTAP6-2 LHX9 LZTS2 MEOX2 MID2 MYOD1 NHLRC4 PIBF1 PNMA1 POF1B POU6F2 PRKAR1B PRR23B SERTAD2 SPAG5 TAX1BP1 TRIM21 TRIM27 TRIM35 TRIM42 TRIP13 TSC1 UBAP2 USP54 ZNF620 ZNF688	28 interacting genes: ACTN3 ANXA7 ATP1B1 CDC73 CDK4 CDKN1A DNAJB11 FANCL GADD45G IGFN1 MAP3K20 MKNK1 NOXA1 PIN1 PRKAB2 RAP1B RCC1 RPS6KA1 RPS6KA5 SCGN SMN1 STK3 TAF1D TK1 TNFSF11 TRIP13 TSC22D1 VAC14
Entrez ID		91156	23564
HPRD ID		16812	09204
Ensembl ID		ENSG00000163395	ENSG00000213722
Uniprot IDs		Q86VF2	O95865 V9HW53
PDB IDs
Enriched GO Terms of Interacting Partners?		Suppression Of Viral Release By Host Negative Regulation Of Viral Transcription Regulation Of Viral Transcription Protein Binding Golgi Organization Protein Localization To Cytoskeleton Sequence-specific Double-stranded DNA Binding	Cytoplasm Nucleus Regulation Of Mitotic Cell Cycle Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Kinase Activity Intracellular Signal Transduction Cytosol Regulation Of Cell Cycle Process Protein Kinase Activity JNK Cascade Response To Phorbol 13-acetate 12-myristate Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Positive Regulation Of Programmed Cell Death Epithelial Cell Proliferation Cellular Response To UV-B Protein Phosphorylation Identical Protein Binding Intracellular Signaling Cassette Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Phosphorylation Magnesium Ion Binding Regulation Of Programmed Cell Death Regulation Of Fibroblast Proliferation Negative Regulation Of Cell Cycle Phase Transition Regulation Of Translation In Response To Stress Positive Regulation Of JNK Cascade Response To UV-B Regulation Of Cell Cycle Phase Transition Cellular Response To Gamma Radiation Regulation Of Mitotic Nuclear Division Negative Regulation Of Cell Cycle Process Regulation Of Multicellular Organismal Process Protein Binding Z Disc Phosphate-containing Compound Metabolic Process Signal Transduction Nucleotide Binding ATP Binding Cyclin Binding Regulation Of Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Regulation Of Nuclear Division Cis-trans Isomerase Activity Positive Regulation Of Apoptotic Process Histone H2AS1 Kinase Activity Positive Regulation Of Mitotic DNA Damage Checkpoint
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