LATS1 and SYNE1

		LATS1	SYNE1
Description		large tumor suppressor kinase 1	spectrin repeat containing nuclear envelope protein 1
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GO Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Centrosome Microtubule Organizing Center Spindle Cytosol Cytoskeleton Midbody Postsynapse Glutamatergic Synapse	P-body Nucleus Nuclear Envelope Nuclear Outer Membrane Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytoskeleton Membrane Sarcomere Nuclear Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex Postsynaptic Membrane
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Nuclear Estrogen Receptor Binding Metal Ion Binding Protein Serine Kinase Activity	RNA Binding Actin Binding Protein Binding Lamin Binding Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Actin Filament Binding Cytoskeleton-nuclear Membrane Anchor Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Sister Chromatid Segregation Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Protein Phosphorylation Intracellular Protein Localization Hormone-mediated Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Keratinocyte Differentiation Regulation Of Actin Filament Polymerization Regulation Of Intracellular Estrogen Receptor Signaling Pathway Hippo Signaling Positive Regulation Of Hippo Signaling Positive Regulation Of Apoptotic Process Regulation Of Protein-containing Complex Assembly NLRP3 Inflammasome Complex Assembly Mitotic Cell Cycle Phase Transition Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Organ Growth Cell Division Mammary Gland Epithelial Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Postsynaptic Density Assembly Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process	Nucleus Organization Golgi Organization Spermatogenesis Cell Differentiation Muscle Cell Differentiation Nuclear Matrix Anchoring At Nuclear Membrane
Pathways		Signaling by Hippo	Meiotic synapsis
Drugs		Fostamatinib
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3) Emery-Dreifuss muscular dystrophy
GWAS		Brain morphology (MOSTest) ( 32665545) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Subcortical volume (MOSTest) ( 32665545) Testicular germ cell tumor ( 28604728)	Appendicular lean mass ( 33097823) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 20351715 21738484 21926972 34002096 28072414 28115744 31043756) Bipolar disorder or major depressive disorder ( 20351715) Bipolar I disorder ( 31043756) Body mass index ( 26426971) Endometriosis ( 28537267) Femur bone mineral density x serum urate levels interaction ( 34046847) Heel bone mineral density ( 30598549 28869591) Hip circumference adjusted for BMI ( 34021172) Post bronchodilator FEV1 ( 26634245) Tonometry ( 17903302) Uterine fibroids ( 30194396 31249589 31649266)
Interacting Genes		53 interacting genes: ALPP APP ARPC3 AURKB CBY2 CDC26 CDK1 CEP76 CREBBP DCAF1 EIF4EBP1 FOXL2 FSD2 GOLGA2 KRT31 LDOC1 LIMK1 LOXL2 LRRK2 MAGI3 MAP3K11 MAP3K2 MAP3K3 MAP4K2 MAP4K4 MINK1 MOAP1 MOB3A MOB3B MOB3C MOB4 MTF1 NEDD4 NUAK1 NUAK2 OSTF1 PABPN1 PPM1F PPP1R11 PPP6R3 PTEN RAC1 SMURF1 SMURF2 SSX2IP STK4 SYNE1 TAOK1 TFIP11 UBE2I WWOX WWP1 ZYX	39 interacting genes: ACTC1 AKAP12 APC BDKRB2 BTG3 CAPN1 CDC42 CDC5L CEP63 DISC1 DSCAM DSCR9 DTNBP1 ECPAS EMD GPX2 IL22RA2 ITSN1 IYD LATS1 LINC00839 LMNA MTDH MUSK MYOM1 NDEL1 NUP43 PCNT RAET1E RAET1L SH3BP5 TNIK TP53RK ULBP1 ULBP2 USP21 USP7 XIAP ZC3H12D
Entrez ID		9113	23345
HPRD ID		09147	09762
Ensembl ID		ENSG00000131023	ENSG00000131018
Uniprot IDs		O95835	A0A0C4DG40 B4E3R1 B7Z9Y6 F8WAI0 Q8NF91
PDB IDs		4ZRK 5B5W 5BRK 7LWH	4DXR 6R15 6XF2
Enriched GO Terms of Interacting Partners?		Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Modification Process Cytoplasm Kinase Activity Protein Kinase Activity Intracellular Signal Transduction Transferase Activity Protein Phosphorylation Phosphorylation MAPK Cascade Intracellular Signaling Cassette Signal Transduction Regulation Of Hippo Signaling Protein Metabolic Process ATP Binding MAP Kinase Kinase Kinase Activity Nucleotide Binding Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Nucleus Regulation Of JNK Cascade Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Macromolecule Metabolic Process Positive Regulation Of JNK Cascade Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process JNK Cascade Protein Autophosphorylation Post-translational Protein Modification Protein Binding Regulation Of Cell-matrix Adhesion Regulation Of Synaptic Vesicle Endocytosis Regulation Of Focal Adhesion Assembly Regulation Of Cell-substrate Adhesion Regulation Of Cell-substrate Junction Organization Central Nervous System Development Regulation Of Synaptic Vesicle Recycling Cytoskeleton Positive Regulation Of Focal Adhesion Assembly Golgi Disassembly MAP Kinase Kinase Kinase Kinase Activity Tangential Migration From The Subventricular Zone To The Olfactory Bulb Wnt Signaling Pathway, Planar Cell Polarity Pathway Response To Copper Ion	Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Antigen Natural Killer Cell Lectin-like Receptor Binding Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of T Cell Mediated Cytotoxicity Signal Transduction Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Leukocyte Mediated Cytotoxicity Regulation Of Postsynapse Organization Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Cytoskeleton Organization Regulation Of Synapse Organization Microtubule Organizing Center Molecular Adaptor Activity Regulation Of Leukocyte Mediated Cytotoxicity Radial Glia-guided Pyramidal Neuron Migration Antigen Processing And Presentation Centrosome Regulation Of T Cell Mediated Immunity Intracellular Signal Transduction Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Cell Cycle Natural Killer Cell Mediated Immunity Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Cell Projection Organization Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leading Edge Membrane Positive Regulation Of Lymphocyte Mediated Immunity Glutamatergic Synapse Regulation Of Dendritic Spine Development Positive Regulation Of Adaptive Immune Response Negative Regulation Of Cyclin-dependent Protein Kinase Activity Cytoskeleton Neuron Projection Morphogenesis Cytosol Wnt Signaling Pathway Positive Regulation Of Pseudopodium Assembly Cell Projection Morphogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Leukocyte Mediated Cytotoxicity Regulation Of Cell Projection Organization Positive Regulation Of Cellular Component Organization Regulation Of Wnt Signaling Pathway Cerebral Cortex Radially Oriented Cell Migration Regulation Of Protein Localization
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