LATS1 and MOB3A

Number of citations of the paper that reports this interaction (PubMedID 19739119)
0

Data Source:
BioGRID (pull down)

		LATS1	MOB3A
Description		large tumor suppressor kinase 1	MOB kinase activator 3A
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Centrosome Microtubule Organizing Center Spindle Cytosol Cytoskeleton Midbody Postsynapse Glutamatergic Synapse	Nucleus Cytoplasm
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Nuclear Estrogen Receptor Binding Metal Ion Binding Protein Serine Kinase Activity	Protein Kinase Activator Activity Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Sister Chromatid Segregation Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Protein Phosphorylation Intracellular Protein Localization Hormone-mediated Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Keratinocyte Differentiation Regulation Of Actin Filament Polymerization Regulation Of Intracellular Estrogen Receptor Signaling Pathway Hippo Signaling Positive Regulation Of Hippo Signaling Positive Regulation Of Apoptotic Process Regulation Of Protein-containing Complex Assembly NLRP3 Inflammasome Complex Assembly Mitotic Cell Cycle Phase Transition Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Organ Growth Cell Division Mammary Gland Epithelial Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Postsynaptic Density Assembly Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process	Signal Transduction
Pathways		Signaling by Hippo
Drugs		Fostamatinib
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Subcortical volume (MOSTest) ( 32665545) Testicular germ cell tumor ( 28604728)
Interacting Genes		53 interacting genes: ALPP APP ARPC3 AURKB CBY2 CDC26 CDK1 CEP76 CREBBP DCAF1 EIF4EBP1 FOXL2 FSD2 GOLGA2 KRT31 LDOC1 LIMK1 LOXL2 LRRK2 MAGI3 MAP3K11 MAP3K2 MAP3K3 MAP4K2 MAP4K4 MINK1 MOAP1 MOB3A MOB3B MOB3C MOB4 MTF1 NEDD4 NUAK1 NUAK2 OSTF1 PABPN1 PPM1F PPP1R11 PPP6R3 PTEN RAC1 SMURF1 SMURF2 SSX2IP STK4 SYNE1 TAOK1 TFIP11 UBE2I WWOX WWP1 ZYX	7 interacting genes: APP FBXO7 LATS1 LATS2 NEDD4 NEDD4L TGIF1
Entrez ID		9113	126308
HPRD ID		09147	17583
Ensembl ID		ENSG00000131023	ENSG00000172081
Uniprot IDs		O95835	Q96BX8
PDB IDs		4ZRK 5B5W 5BRK 7LWH
Enriched GO Terms of Interacting Partners?		Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Modification Process Cytoplasm Kinase Activity Protein Kinase Activity Intracellular Signal Transduction Transferase Activity Protein Phosphorylation Phosphorylation MAPK Cascade Intracellular Signaling Cassette Signal Transduction Regulation Of Hippo Signaling Protein Metabolic Process ATP Binding MAP Kinase Kinase Kinase Activity Nucleotide Binding Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Nucleus Regulation Of JNK Cascade Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Macromolecule Metabolic Process Positive Regulation Of JNK Cascade Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process JNK Cascade Protein Autophosphorylation Post-translational Protein Modification Protein Binding Regulation Of Cell-matrix Adhesion Regulation Of Synaptic Vesicle Endocytosis Regulation Of Focal Adhesion Assembly Regulation Of Cell-substrate Adhesion Regulation Of Cell-substrate Junction Organization Central Nervous System Development Regulation Of Synaptic Vesicle Recycling Cytoskeleton Positive Regulation Of Focal Adhesion Assembly Golgi Disassembly MAP Kinase Kinase Kinase Kinase Activity Tangential Migration From The Subventricular Zone To The Olfactory Bulb Wnt Signaling Pathway, Planar Cell Polarity Pathway Response To Copper Ion	Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Protein Localization Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Regulation Of Developmental Process Negative Regulation Of Signal Transduction Negative Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Synapse Organization Regulation Of Developmental Growth Sodium Channel Inhibitor Activity Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Potassium Channel Inhibitor Activity Negative Regulation Of Cyclin-dependent Protein Kinase Activity Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Sodium Ion Transport Regulation Of Intracellular Signal Transduction Negative Regulation Of Canonical Wnt Signaling Pathway Hormone-mediated Signaling Pathway Regulation Of Protein Localization To Nucleus Receptor Catabolic Process Positive Regulation Of Hippo Signaling Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Catabolic Process Regulation Of Growth Hippo Signaling Regulation Of Cellular Component Organization Positive Regulation Of Protein Catabolic Process Negative Regulation Of Potassium Ion Transport Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Protein Metabolic Process Neuromuscular Junction Development Regulation Of Canonical Wnt Signaling Pathway Synapse Organization Ubiquitin-protein Transferase Activity Regulation Of Monoatomic Cation Transmembrane Transport Cellular Developmental Process Protein Modification Process Protein Metabolic Process Protein Polyubiquitination Regulation Of Hippo Signaling Receptor Metabolic Process Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Monoatomic Ion Transmembrane Transport
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