MTA1 and NACC2

Number of citations of the paper that reports this interaction (PubMedID 22926524)
0

Data Source:
BioGRID (pull down)

		MTA1	NACC2
Description		metastasis associated 1	NACC family member 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Cytosol Cytoskeleton Microtubule NuRD Complex	Chromatin Nucleus Nucleolus Mitochondrion Nuclear Lumen
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Protein-containing Complex Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Chromatin Remodeling Regulation Of DNA-templated Transcription Signal Transduction Response To Ionizing Radiation Circadian Regulation Of Gene Expression Regulation Of Cell Fate Specification Entrainment Of Circadian Clock By Photoperiod Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Locomotor Rhythm Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Rhythmic Process Positive Regulation Of Protein Autoubiquitination Regulation Of Stem Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Protein-containing Complex Localization Regulation Of Cell Population Proliferation Negative Regulation Of DNA-templated Transcription Protein Homooligomerization Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways		HDACs deacetylate histones SUMOylation of transcription factors ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Sjögren's syndrome ( 28076899) Ulcerative colitis ( 28067908)
Interacting Genes		47 interacting genes: AMN BLOC1S1 CCNH CSNK1G2 CYSRT1 DDX18 DYNLL1 DYRK1A E2F1 ERCC6 ESR1 FHL3 GPR183 GRB2 H3-4 HDAC1 HDAC2 HIF1A ITGB3BP JUN KHDRBS2 KPNA4 KRT31 KRT40 KRTAP10-8 LMO4 LRRK2 LZTS2 MAGEA11 MNAT1 NACC2 NBPF19 NELFCD NOTCH2NLA PICK1 PLEKHG4 RBBP4 SAT1 SH3GL1 SH3GLB1 SNAI1 SUMO2 TEX11 TP53 TRIM25 UBE2I ZEB2	5 interacting genes: EPS8 HDAC2 MTA1 MTA2 MTA3
Entrez ID		9112	138151
HPRD ID		04633	09831
Ensembl ID		ENSG00000182979	ENSG00000148411
Uniprot IDs		E7ESY4 Q13330 Q9BRL8	Q96BF6
PDB IDs		4BKX 4PBY 4PBZ 4PC0 5FXY 5ICN 6G16 6ZRC 6ZRD 7AO8 7AO9 7AOA
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Binding Negative Regulation Of RNA Metabolic Process Regulation Of Cell Fate Specification Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Nucleoplasm Transcription Regulator Complex Regulation Of Fibroblast Proliferation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Cell Communication Regulation Of Signaling Eyelid Development In Camera-type Eye Regulation Of Cell Fate Commitment Regulation Of Transcription By RNA Polymerase II Cellular Response To Stress Enzyme Binding NuRD Complex Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Transcription Factor TFIIK Complex Negative Regulation Of Macromolecule Metabolic Process Developmental Process Regulation Of Apoptotic Process Regulation Of Cell Population Proliferation Protein Lysine Delactylase Activity Fungiform Papilla Formation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Sin3-type Complex Negative Regulation Of Macromolecule Biosynthetic Process CAK-ERCC2 Complex Protein Decrotonylase Activity Histone Decrotonylase Activity Negative Regulation Of Stem Cell Population Maintenance Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Nuclear Body Response To Oxidative Stress	NuRD Complex Regulation Of Cell Fate Specification Regulation Of Cell Fate Commitment Regulation Of Stem Cell Differentiation Histone Deacetylase Binding Behavioral Response To Ethanol Chromatin Binding Chromatin Remodeling Histone Deacetylase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Corepressor Activity Chromatin Organization Epigenetic Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Nucleosomal DNA Binding Transcription Coactivator Activity Regulation Of Developmental Process Histone Deacetylase Complex Circadian Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Sequence-specific DNA Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Male Mating Behavior Positive Regulation Of Granulosa Cell Proliferation Granulosa Cell Proliferation Regulation Of Cell Differentiation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Protein De-2-hydroxyisobutyrylase Activity Circadian Rhythm Mitotic Cell Cycle Phase Transition Adult Behavior Cell Cycle Phase Transition Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Lysine Delactylase Activity Fungiform Papilla Formation Positive Regulation Of Protein Autoubiquitination Negative Regulation Of Gene Expression, Epigenetic Chromosome, Telomeric Region DNA-binding Transcription Factor Binding Protein Decrotonylase Activity Histone Decrotonylase Activity Locomotory Behavior Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Hair Follicle Placode Formation Regulation Of Protein Autoubiquitination
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