PKMYT1 and MAPK10

Number of citations of the paper that reports this interaction (PubMedID 19204086)
51

Data Source:
BioGRID (pull down, enzymatic study)

		PKMYT1	MAPK10
Description		protein kinase, membrane associated tyrosine/threonine 1	mitogen-activated protein kinase 10
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GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Activity MAP Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Regulation Of Mitotic Nuclear Division Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Meiotic Cell Cycle Negative Regulation Of G2/MI Transition Of Meiotic Cell Cycle	MAPK Cascade Protein Phosphorylation Signal Transduction JNK Cascade Response To Light Stimulus Fc-epsilon Receptor Signaling Pathway Regulation Of Circadian Rhythm Rhythmic Process Cellular Senescence
Pathways		Polo-like kinase mediated events Cyclin A/B1/B2 associated events during G2/M transition G2/M DNA replication checkpoint	Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Activation of the AP-1 family of transcription factors
Drugs		Fostamatinib	Minocycline Pyrazolanthrone Cyclohexyl-{4-[5-(3,4-Dichlorophenyl)-2-Piperidin-4-Yl-3-Propyl-3h-Imidazol-4-Yl]-Pyrimidin-2-Yl}Amine Cyclopropyl-{4-[5-(3,4-Dichlorophenyl)-2-[(1-Methyl)-Piperidin]-4-Yl-3-Propyl-3h-Imidazol-4-Yl]-Pyrimidin-2-Yl}Amine 9-(4-Hydroxyphenyl)-2,7-Phenanthroline Phosphoaminophosphonic Acid-Adenylate Ester N-(tert-butyl)-4-[5-(pyridin-2-ylamino)quinolin-3-yl]benzenesulfonamide N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide 4-{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-N-ethylpiperidine-1-carboxamide (3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-[(E)-2-phenylethenyl]-1H-indole-2,3-dione 3-oxime (3E)-5-fluoro-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-1H-indole-2,3-dione 3-oxime (3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-phenyl-1H-indole-2,3-dione 3-oxime 5-bromo-N-(3-chloro-2-(4-(prop-2-ynyl)piperazin-1-yl)phenyl)furan-2-carboxamide N-cyclohexyl-4-imidazo[1,2-a]pyridin-3-yl-N-methylpyrimidin-2-amine N-{2'-[(4-FLUOROPHENYL)AMINO]-4,4'-BIPYRIDIN-2-YL}-4-METHOXYCYCLOHEXANECARBOXAMIDE 2-{4-[(4-imidazo[1,2-a]pyridin-3-ylpyrimidin-2-yl)amino]piperidin-1-yl}-N-methylacetamide 1-(3-bromophenyl)-7-chloro-6-methoxy-3,4-dihydroisoquinoline Fostamatinib Halicin
Diseases
GWAS		Metabolic syndrome ( 20694148)	Cleft lip with or without cleft palate x maternal periconceptional smoking interaction (parent of origin effect) ( 31372216) Cobalt levels ( 26025379) Diisocyanate-induced asthma ( 25918132) Gait speed in old age ( 28077804) Liver enzyme levels (alanine transaminase) ( 22001757 33972514) Multiple sclerosis ( 31604244) Peripheral artery disease ( 25009551) Response to cytidine analogues (gemcitabine) ( 24483146) Triglyceride levels ( 32154731 32203549)
Interacting Genes		24 interacting genes: ABHD16A BCL2 CCNB1 CD3E CD79A CDK1 CLDN8 ELOVL4 FATE1 LIME1 LRRC25 MAPK10 MAPK8 PIN1 PLK1 RETREG3 SLC10A1 SLC30A8 SLC61A1 SLC71A2 STEAP3 TMEM101 TMEM229B TMX2	40 interacting genes: APP ARRB1 ARRB2 ATF2 BCL2L11 CDK5 CDKN1B CDKN2A CDKN2C CEP290 CREBBP DUSP10 DUSP16 DUSP9 ELK1 FBXO7 GTF3C1 HAX1 HDAC9 HNRNPK HRAS JUN KIF26A KIF5A LDHA MAP2K4 MAPK8IP2 MAPK8IP3 MAPKBP1 MAPT MCL1 PKMYT1 PLIN2 RELA SH3BP5 STMN2 TNIP1 TP53 UBE3A UNC119
Entrez ID		9088	5602
HPRD ID		03920	04207
Ensembl ID		ENSG00000127564	ENSG00000109339
Uniprot IDs		Q0IJ49 Q99640	A0A286YEQ0 A0A286YF97 D6RJF9 F8W9R5 P53779 Q499Y8
PDB IDs		3P1A 5VCV 5VCW 5VCX 5VCY 5VCZ 5VD0 5VD1 5VD3 8D6C 8D6D 8D6E 8D6F 8WJY 8ZTX 8ZU2 8ZUD 8ZUL	1JNK 1PMN 1PMU 1PMV 2B1P 2EXC 2O0U 2O2U 2OK1 2P33 2R9S 2WAJ 2ZDT 2ZDU 3CGF 3CGO 3DA6 3FI2 3FI3 3FV8 3G90 3G9L 3G9N 3KVX 3OXI 3OY1 3PTG 3RTP 3TTI 3TTJ 3V6R 3V6S 4H36 4H39 4H3B 4KKE 4KKG 4KKH 4U79 4W4V 4W4W 4W4X 4W4Y 4WHZ 4X21 4Y46 4Y5H 4Z9L 6EKD 6EMH 6EQ9 7KSI 7KSJ 7KSK 7ORE 7ORF 7S1N 7YL1 8BZP 8ENJ 8VNX 8VO4 8VS0 8VTF 8WGF
Enriched GO Terms of Interacting Partners?		Membrane Immune Response-regulating Cell Surface Receptor Signaling Pathway Cyclin B1-CDK1 Complex Protein Localization To Site Of Double-strand Break JUN Kinase Activity Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport B Cell Receptor Complex Immune Response-regulating Signaling Pathway Mitotic Cell Cycle Phase Transition Antigen Receptor-mediated Signaling Pathway B Cell Receptor Signaling Pathway G2/M Transition Of Mitotic Cell Cycle Cell Cycle Phase Transition Cell Cycle G2/M Phase Transition Ventricular Cardiac Muscle Cell Development Mitotic Nuclear Membrane Disassembly Striated Muscle Cell Development Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Membrane Disassembly Nuclear Membrane Disassembly MAP Kinase Activity Muscle Cell Development Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Toxic Substance Regulation Of Sister Chromatid Segregation Regulation Of Attachment Of Spindle Microtubules To Kinetochore Outer Kinetochore Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Localization To Chromosome Peptidyl-threonine Phosphorylation Microtubule Polymerization Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Regulation Of Circadian Rhythm Fc-epsilon Receptor Signaling Pathway Lymphocyte Proliferation Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Nuclear Division Regulation Of Cell Cycle G2/M Phase Transition Mononuclear Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Endoplasmic Reticulum Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Involved In Mitosis Positive Regulation Of Chromosome Segregation Regulation Of Chromosome Segregation Cellular Response To Hypoxia Response To Iron Ion Positive Regulation Of Cell Cycle G2/M Phase Transition Response To Light Stimulus	Cytoplasm Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Regulation Of Signal Transduction Intracellular Signaling Cassette Regulation Of Neuron Apoptotic Process Regulation Of Cell Communication Regulation Of Signaling JUN Kinase Binding Positive Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Nucleus Regulation Of Apoptotic Process MAPK Cascade Regulation Of Programmed Cell Death Cytosol Regulation Of Protein Modification Process Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Signal Transduction Positive Regulation Of Signal Transduction RNA Polymerase II-specific DNA-binding Transcription Factor Binding JNK Cascade MAP Kinase Tyrosine Phosphatase Activity Cellular Senescence Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Apoptotic Process Signal Transduction Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Signaling Negative Regulation Of Cell Communication Protein Tyrosine/threonine Phosphatase Activity Protein Kinase Binding Programmed Cell Death Regulation Of Growth Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of JNK Cascade Regulation Of Post-translational Protein Modification Negative Regulation Of Multicellular Organismal Process Regulation Of MiRNA Metabolic Process Regulation Of Multicellular Organismal Process Negative Regulation Of Post-translational Protein Modification Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription General Transcription Initiation Factor Binding Nucleoplasm Regulation Of Apoptotic Signaling Pathway
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