PRC1 and KIF4A

Number of citations of the paper that reports this interaction (PubMedID 31586073)
53

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down, two hybrid)

		PRC1	KIF4A
Description		protein regulator of cytokinesis 1	kinesin family member 4A
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GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Spindle Cytosol Cytoskeleton Microtubule Spindle Microtubule Plasma Membrane Microtubule Cytoskeleton Midbody Intercellular Bridge Contractile Ring Mitotic Spindle Midzone	Nucleus Chromosome Cytoplasm Spindle Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Spindle Microtubule Membrane Nuclear Matrix Midbody Axon Cytoplasm
	Molecular Function	Protein Binding Microtubule Binding Kinesin Binding Protein Kinase Binding Identical Protein Binding	Nucleotide Binding DNA Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Metal Ion Binding Iron-sulfur Cluster Binding
	Biological Process	Mitotic Spindle Elongation Microtubule Cytoskeleton Organization Positive Regulation Of Cell Population Proliferation Regulation Of Cytokinesis Mitotic Spindle Midzone Assembly Cell Division	Mitotic Cytokinesis Organelle Organization Microtubule-based Movement Mitotic Spindle Organization Anterograde Axonal Transport Spindle Elongation Mitotic Spindle Midzone Assembly
Pathways		RHO GTPases activate CIT	MHC class II antigen presentation Recycling pathway of L1 Recycling pathway of L1 COPI-dependent Golgi-to-ER retrograde traffic Kinesins
Drugs
Diseases
GWAS		Breast cancer ( 25038754 29059683) Mean platelet volume ( 27863252 32888494) Multisite chronic pain ( 31194737 33830993) Red cell distribution width ( 32888494) Type 2 diabetes ( 20581827 22885922 24509480 26818947 28869590 30054458 30297969 30718926 32499647)
Interacting Genes		43 interacting genes: AKAP9 BICD2 CASK CCDC85B CCNA2 CCNB1 CCNE1 CDK1 CDK2 CEBPA CINP EMG1 EXOSC7 EXOSC8 FXR2 KIF3B KIF4A KLC2 KLC4 KRT20 LARP4 MAT2A NDEL1 NUDT16 OGT PBK PCM1 PKIA PLK1 PPIE RACGAP1 RBM10 RBM17 RBM22 RPA2 SF3B2 SLAIN1 SUMO2 TFIP11 THOC1 TRIM37 USHBP1 YWHAE	9 interacting genes: APP CEBPA DNMT3B HMG20B PDZD11 PRC1 SUMO2 TAF1 TTF2
Entrez ID		9055	24137
HPRD ID		17899	06606
Ensembl ID		ENSG00000198901	ENSG00000090889
Uniprot IDs		O43663	O95239 Q59HG1
PDB IDs		3NRX 3NRY 4L3I 4L6Y 5KMG 7VBG	6OYL
Enriched GO Terms of Interacting Partners?		Microtubule-based Process Nucleic Acid Metabolic Process Organelle Organization Microtubule Cytoskeleton Organization G2/M Transition Of Mitotic Cell Cycle Cytoskeleton Cell Cycle G2/M Phase Transition Cytoskeleton Organization Nucleobase-containing Compound Metabolic Process Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Cell Cycle Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Process Mitotic Cell Cycle Phase Transition Cytoplasm G1/S Transition Of Mitotic Cell Cycle Regulation Of Intracellular Protein Transport MRNA Metabolic Process Cell Cycle G1/S Phase Transition Nucleoplasm Nucleus Cell Cycle Phase Transition Centrosome Separation Centrosome Spindle Microtubule Microtubule Organizing Center RNA Metabolic Process Regulation Of Intracellular Transport Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Ubiquitin-dependent Protein Catabolic Process Kinesin Complex Cyclin A2-CDK1 Complex Cyclin B1-CDK1 Complex Regulation Of G2/M Transition Of Mitotic Cell Cycle MRNA Splicing, Via Spliceosome Regulation Of Proteasomal Protein Catabolic Process RNA Binding Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Nucleocytoplasmic Transport RNA Splicing, Via Transesterification Reactions Cell Division Cyclin A2-CDK2 Complex Cyclin E1-CDK2 Complex Cyclin-dependent Protein Kinase Activity U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Regulation Of Mitotic Cell Cycle Phase Transition Protein Localization To Organelle Regulation Of Attachment Of Spindle Microtubules To Kinetochore Mitotic DNA Damage Checkpoint Signaling	Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Regulation Of Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Presynapse DNA Binding Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Protein Metabolic Process Regulation Of Response To Calcium Ion Amylin Binding Regulation Of Protein Metabolic Process Positive Regulation Of Toll Signaling Pathway RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates Protein Sumoylation Positive Regulation Of Androgen Receptor Signaling Pathway Protein Heterodimerization Activity Positive Regulation Of DNA-templated Transcription Initiation Acetylcholine Receptor Activator Activity Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Neuron Differentiation Lipoprotein Particle Positive Regulation Of Protein Import Regulation Of DNA-templated Transcription Initiation Response To Vitamin B2 C/EBP Complex Negative Regulation Of Post-translational Protein Modification Negative Regulation Of Protein Autoubiquitination Mitotic Spindle Elongation PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Notch Signaling Pathway Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Cell Cycle CHOP-C/EBP Complex
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