CCNT2 and HEXIM1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vitro, in vivo)

		CCNT2	HEXIM1
Description		cyclin T2	HEXIM P-TEFb complex subunit 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cyclin/CDK Positive Transcription Elongation Factor Complex Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm 7SK SnRNP
	Molecular Function	Transcription Coactivator Binding Chromatin Binding Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity RNA Polymerase Binding 7SK SnRNA Binding	Protein Kinase Inhibitor Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding SnRNA Binding Identical Protein Binding 7SK SnRNA Binding P-TEFb Complex Binding Transcription Regulator Inhibitor Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Skeletal Muscle Tissue Development Early Viral Transcription Late Viral Transcription Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Elongation By RNA Polymerase II Host-mediated Activation Of Viral Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Muscle Cell Differentiation Cell Division	Negative Regulation Of Transcription By RNA Polymerase II Activation Of Innate Immune Response Immune System Process Heart Development Negative Regulation Of Viral Transcription Negative Regulation Of Transcription Elongation By RNA Polymerase II Innate Immune Response Negative Regulation Of DNA-templated Transcription Positive Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat HIV elongation arrest and recovery Pausing and recovery of HIV elongation SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Body mass index ( 26426971) Diisocyanate-induced asthma ( 25918132) Parkinson's disease ( 28892059) Waist-to-hip ratio adjusted for BMI ( 28552196) Walking pace ( 33128006)	Appendicular lean mass ( 33097823) Asthma ( 31619474 31959851) Brain morphology (MOSTest) ( 32665545) Craniofacial microsomia ( 26853712) Insomnia ( 32332799) Male-pattern baldness ( 28196072) Systolic blood pressure ( 19430483)
Interacting Genes		7 interacting genes: AKT3 BRD4 CDK9 HEXIM1 PKN1 RB1 SUPT5H	13 interacting genes: CCNT1 CCNT2 CDK9 CEBPA EGFR ESR1 HEXIM2 PPM1G RELA RN7SK TERF1 TERF2 UBE2O
Entrez ID		905	10614
HPRD ID		04839	09544
Ensembl ID		ENSG00000082258	ENSG00000186834
Uniprot IDs		B4DH21 O60583	O94992
PDB IDs		2IVX	2GD7 3S9G
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Negative Regulation Of DNA-templated Transcription, Elongation P-TEFb Complex Binding Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription, Elongation Cyclin/CDK Positive Transcription Elongation Factor Complex 7SK SnRNA Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Protein Serine/threonine Kinase Activity SnRNA Binding Chromatin Binding Nucleoplasm Negative Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Host-mediated Perturbation Of Viral Transcription Chromatin Remodeling Transcription Elongation By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-templated Transcription Elongation Positive Regulation Of RNA Metabolic Process Protein Phosphorylation Protein Serine Kinase Activity Phosphorylation Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Host-mediated Perturbation Of Viral Process Enzyme Binding Histone H4K8ac Reader Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mitotic Cell Cycle Protein Kinase Activity P-TEFb Complex Positive Regulation Of Transcription By RNA Polymerase II Host-mediated Perturbation Of Symbiont Process Multicellular Organismal-level Homeostasis Positive Regulation Of Mitotic Cell Cycle Phase Transition DSIF Complex Histone H3K9ac Reader Activity Histone H4K5ac Reader Activity Histone H4K12ac Reader Activity PML Body Regulation Of Cellular Response To Stress Negative Regulation Of DNA-templated Transcription Nucleus Negative Regulation Of RNA Biosynthetic Process	7SK SnRNA Binding Chromatin Binding Cyclin/CDK Positive Transcription Elongation Factor Complex Nucleobase-containing Compound Biosynthetic Process Transcription Coactivator Binding SnRNA Binding Host-mediated Activation Of Viral Transcription DNA-templated Transcription P-TEFb Complex Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Host-mediated Perturbation Of Viral Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Host-mediated Activation Of Viral Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Nucleoplasm Shelterin Complex Positive Regulation Of Transcription Elongation By RNA Polymerase II Ankyrin Repeat Binding Telomerase Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription, Elongation Protein Kinase Binding Negative Regulation Of Macromolecule Metabolic Process Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding Host-mediated Perturbation Of Viral Process Regulation Of MiRNA Transcription G-rich Strand Telomeric DNA Binding Nucleic Acid Metabolic Process Negative Regulation Of Metabolic Process Telomeric Loop Disassembly Transcription Cis-regulatory Region Binding Regulation Of Macromolecule Biosynthetic Process Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Telomere Capping Regulation Of MiRNA Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Response To Xenobiotic Stimulus Transcription By RNA Polymerase II Nucleus Negative Regulation Of Biosynthetic Process Host-mediated Perturbation Of Symbiont Process
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